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Yi Wen
Life Science
Zhejiang University
Zhejiang
Language: English, Chinese
Glycosylation
Biocompatibility
Chemical Biology
Disease Progression
Stem Cell Differentiation
Enzyme Research
Click Chemistry
Cellular Metabolism
Tumor Proliferation
Immune Therapy
Areas of Focus
- Glycochemistry
- Tumor Biology
- Stem Cell Biology
Work Experience
- 2013-Present - Zhejiang University, School of Life Sciences - Professor
- 2018-Present - First Affiliated Hospital of Zhejiang University School of Medicine - Jointly appointed Professor
- 2008-2012 - California Institute of Technology, USA - Postdoctoral Researcher
Academic Background & Achievements
- 2013-Present: Professor at Zhejiang University, School of Life Sciences
- 2018-Present: Jointly appointed Professor at the First Affiliated Hospital of Zhejiang University School of Medicine
- 2008-2012: Postdoctoral Researcher at California Institute of Technology, USA
- 2002-2008: PhD from The Ohio State University, USA
- 1998-2002: Bachelor from Fudan University
Publications
- O-GlcNAcylation promotes pancreatic tumor growth by regulating malate dehydrogenase 1, Yi W.*, 2022
- O-GlcNAcylation regulates epidermal growth factor receptor intracellular trafficking and signaling, Yi W.*, 2022
- Spatiotemporal activation of protein O-GlcNAcylation in living cells, Yi W.*, 2022
- One-step enzymatic labeling reveals a critical role of O-GlcNAcylation in cell-cycle progression and DNA damage response, Yi W.*, 2021
- O-GlcNAcylation regulates the methionine cycle to promote pluripotency of stem cells, Yi W.*, 2020
- O-GlcNAcylation of PGK1 coordinates glycolysis and TCA cycle to promote tumor growth, Yi W.*, 2020
- O-GlcNAcylation of core components of the translation initiation machinery regulates protein synthesis, Yi W.*, 2019
- An isotope-coded photocleavable probe for quantitative profiling of protein O-GlcNAcylation, Yi W.*, 2019
- O-GlcNAcylation, a sweet link to pathology of diseases, Yi W.*, 2019
- Redox controlled site-specific α2,6-sialylation, Yi W.*, 2019
- Imaging of protein-specific glycosylation by glycan metabolic tagging and in situ proximity ligation, Yi W.*, 2017
- Chemical remodeling cell surface glycans for immunotargeting of tumor cells, Yi W.*, 2017
- Targeting tumor cells by natural anti-carbohydrate antibodies using rhamnose-functionalized liposomes, Yi W.*, 2016
- O-GlcNAcylation of G6PD promotes the pentose phosphate pathway and tumor growth, Yi W.*, 2015
- A Tandem Enzymatic Approach for Detecting and Imaging Tumor-Associated TF Antigen Disaccharide, Yi W.*, 2014
- Regulation of Cancer Metabolism by O-GlcNAcylation, Yi W.*, 2014
- Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism, Yi W.*, 2012
- Chemoenzymatic Probes for Detecting and Imaging Fucosea(1,2)Galactose Glycan Biomarkers, Yi W.*, 2012
- In Vitro Bacterial Polysaccharide Biosynthesis: Defining the Functions of Wzy and Wzz, Yi W.*, 2010
- Remodeling Bacterial Polysaccharides by Metabolic Pathway Engineering, Yi W.*, 2009
Awards
- 2024: Horase S. Isbell Award from the American Chemical Society's Division of Carbohydrate Chemistry
- 2023: National Natural Science Foundation of China 'Outstanding Young Scientist'
- 2022: 'Huiyong Zheng Carbohydrate Science Award' - Young Innovator Award
- 2021: Chinese Society of Biotechnology 'Shu Zheng Sugar Science Award' - Outstanding Young Award
- 2021: Mizutani Foundation for Glycoscience Academic Research Award
- 2013: International Glycoconjugate Organization Young Glycoscientist
- 2014: National Natural Science Foundation of China 'Excellent Young Scientist'
- 2013: National High-Level Talents Project (Youth)
- 2010: Postdoctoral Fellowship, Tobacco-Related Disease Program, California, USA
