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Lu Yang Yu
Life Science
Zhejiang University
Zhejiang
Language: Chinese, English
Vascular Disease
Pathophysiology
Stem Cells
Therapy
Space
Biology
Molecular Mechanisms
Cell Differentiation
Disease Modeling
Drug Intervention
Areas of Focus
- Cardiovascular pathophysiology
- Perinatal stem cell therapy
- Space biology
Work Experience
- 2016-present: Vice Dean, School of Life Sciences, Zhejiang University
- 2015-2016: Assistant to the Dean, School of Life Sciences, Zhejiang University
- 2012-present: Professor, Doctoral Supervisor, School of Life Sciences, Zhejiang University
- 2012: Associate Research Scientist, PI, Yale University School of Medicine, Vascular Biology and Therapeutics/Pathology
- 2010-2011: Associate Research Scientist, Yale University School of Medicine, Vascular Biology and Therapeutics/Pathology
- 2006-2010: Postdoctoral Fellow, Yale University School of Medicine, Vascular Biology and Therapeutics
- 2005-2006: Research Assistant, Institute of Infectious Diseases, Zhejiang University Medical School
Academic Background & Achievements
- 2000-2005: PhD, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Supervisor: Guo Lihe
- 1996-2000: Bachelor, Department of Biological Sciences and Technology, Zhejiang University
- Honorary Professor at the University of Edinburgh
Publications
- SUMOylation Fine-Tunes Endothelial HEY1 in the Regulation of Angiogenesis, Ren R, Ding S, Ma K, Jiang Y, Wang Y, Chen J, Wang Y, Kou Y, Fan X, Zhu X, Qin L, Qiu C, Simons M, Wei X, Yu L, 2024
- Biomimetic Corneal Stroma for Scarless Corneal Wound Healing via Structural Restoration and Microenvironment Modulation, Huang J, Jiang T, Li J, Qie J, Cheng X, Wang Y, Zhou T, Liu J, Han H, Yao K, Yu L, 2023
- A 3D-Printed Dual Driving Forces Scaffold with Self-Promoted Cell Absorption for Spinal Cord Injury Repair, Qiu C, Sun Y, Li J, Zhou J, Xu Y, Qiu C, Yu K, Liu J, Jiang Y, Cui W, Wang G, Liu H, Yuan W, Jiang T, Kou Y, Ge Z, He Z, Zhang S, He Y, Yu L, 2023
- Endothelial FIS1 DeSUMOylation Protects Against Hypoxic Pulmonary Hypertension, Zhou X, Jiang Y, Wang Y, Fan L, Zhu Y, Chen Y, Wang Y, Zhu Y, Wang H, Pan Z, Li Z, Zhu X, Ren R, Ge Z, Lai D, Lai EY, Chen T, Wang K, Liang P, Qin L, Liu C, Qiu C, Simons M, Yu L, 2023
- Acetate controls endothelial-to-mesenchymal transition, Zhu X, Wang Y, Soaita I, Lee HW, Bae H, Boutagy N, Zhang RM, Bowman C, Xu Y, Trefely S, Chen Y, Qin L, Sessa W, Tellides G, Jang C, Snyder NW, Yu L, Arany Z, Simons M, 2023
- FGFR1 SUMOylation coordinates endothelial angiogenic signaling in angiogenesis, Zhu X, Qiu C, Wang Y, Jiang Y, Chen Y, Fan L, Ren R, Wang Y, Chen Y, Feng Y, Zhou X, Zhu Y, Ge Z, Lai D, Qin L, Simons M, Yu L, 2022
- Nucleoside/nucleotide reverse transcriptase inhibitors attenuate angiogenesis and lymphangiogenesis by impairing receptor tyrosine kinases signalling in endothelial cells, Song L, Ding S, Ge Z, Zhu X, Qiu C, Wang Y, Lai E, Yang W, Sun Y, Chow SA, Yu L, 2018
- Diesel exhaust inhalation exposure induces pulmonary arterial hypertension in mice, Liu J, Ye X, Ji D, Zhou X, Qiu C, Liu W, Yu L, 2018
- SUMOylation Negatively Regulates Angiogenesis by Targeting Endothelial NOTCH Signaling, Zhu X, Ding S, Qiu C, Shi Y, Song L, Wang Y, Wang Y, Li J, Wang Y, Sun Y, Qin L, Chen J, Simons M, Min W, Yu L, 2017
- The critical role of SENP1-mediated GATA2 deSUMOylation in promoting endothelial activation in graft arteriosclerosis, Qiu C, Wang Y, Zhao H, Qin L, Shi Y, Zhu X, Song L, Zhou X, Chen J, Zhou H, Zhang H, Tellides G, Min W, Yu L, 2017
- SOCS1 prevents graft arteriosclerosis by preserving endothelial cell function, Qin L, Huang Q, Zhang H, Liu R, Tellides G, Min W, Yu L, 2014
- Biological characterization of human amniotic epithelial cells in a serum-free system and their safety evaluation, Yang PJ, Yuan WX, Liu J, Li JY, Tan B, Qiu C, Zhu XL, Qiu C, Lai DM, Guo LH, Yu LY, 2018
- AIP1 Prevents Graft Arteriosclerosis by Inhibiting Interferon-γ-Dependent Smooth Muscle Cell Proliferation and Intimal Expansion, Yu L, Ji W, Zhang H, Renda MJ, He Y, Lin S, Cheng E, Krause DS, Min W, 2011
- SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis, Yu L, Ji W, Zhang H, Renda MJ, He Y, Lin S, Cheng E, Krause DS, Min W, 2010
- Endothelial miR-196b-5p regulates angiogenesis via the hypoxia/miR-196b-5p/HMGA2/HIF1α loop, Ren R, Ma K, Jiang Y, Chen J, Kou Y, Ge Z, Chen Z, Wei X, Yu L, 2023
- Therapeutic Effect of Biomimetic Scaffold Loaded with Human Amniotic Epithelial Cell-Derived Neural-like Cells for Spinal Cord Injury, Qiu C, Sun Y, Li J, Xu Y, Zhou J, Qiu C, Zhang S, He Y, Yu L, 2022
- Repair of Retinal Degeneration by Human Amniotic Epithelial Stem Cell-Derived Photoreceptor-like Cells, Li J, Qiu C, Zhou J, Wei Y, Yuan W, Liu J, Cui W, Huang J, Qiu C, Guo L, Yu L, Ge Z, 2022
- Human Amniotic Epithelial Stem Cell-Derived Retinal Pigment Epithelium Cells Repair Retinal Degeneration, Li J, Qiu C, Wei Y, Yuan W, Liu J, Cui W, Zhou J, Qiu C, Guo L, Huang L, Ge Z, Yu L, 2021
- Human Amniotic Epithelial Stem Cells: A Promising Seed Cell for Clinical Applications, Qiu C, Ge Z, Cui W, Yu L, Li J, 2020
- Therapeutic effect of human amniotic epithelial cells in murine models of Hashimoto's thyroiditis and Systemic lupus erythematosus, Tan B, Yuan W, Li J, Yang P, Ge Z, Liu J, Qiu C, Zhu X, Qiu C, Lai D, Guo L, Wang L, Yu L, 2018
- Mouse Models for Graft Arteriosclerosis, Qin, L., Yu, L., Min, W. (co-corresponding author), 2013
- Stabilization of VEGFR2 signaling by cerebral cavernous malformation 3 is critical for vascular development, He Y, Zhang H, Yu L, Gunel M, Boggon TJ, Chen H, Min W, 2010
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Awards
- 2019: Second Prize, Scientific and Technological Progress Award, Ministry of Education
- 2017: Young Scholar Award in Basic Research, China Heart Congress
- 2015: National Natural Science Foundation of China, Outstanding Young Scientist
- 2015: Zhejiang Provincial Natural Science Foundation, Outstanding Young Scientist
- 2011: Scientist Development Grant Award, American Heart Association
- 2010: A. D. Sobel - ASIP Education Fund Scholar Award, American Society for Pathology
