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Qiang Zhu
Life Science
Zhejiang University
Zhejiang
Language: Chinese, English
O-Glcnac
Tumor Metabolism
Metabolic Reprogramming
Glycosylation
Biochemistry
Cell Biology
Molecular Mechanisms
Cancer Research
Biological Functions
Regulatory Mechanisms
Areas of Focus
- O-GlcNAc modification and tumor metabolic reprogramming
- Core fucosylation and tumor immune evasion
- Development and application of specific glycan labeling methods
Work Experience
- 2023-12 to present - Zhejiang University, School of Life Sciences, Hundred Talents Program Researcher
- 2020-07 to 2023-11 - Zhejiang University, School of Life Sciences, Postdoctoral Researcher
Academic Background & Achievements
- 2015-09 to 2020-06 PhD in Biochemistry and Molecular Biology, Zhejiang University
- Undertook projects funded by the National Natural Science Foundation of China and the Postdoctoral Science Foundation
Publications
- The OGT-c-Myc-PDK2 axis rewires the TCA cycle and promotes colorectal tumor growth, Qiang Zhu*, Wen Yi*, 2024
- A Computational and Chemical Design Strategy for Manipulating Glycan-Protein Recognition, Qiang Zhu, Yong Wang*, Wen Yi, 2024
- O-GlcNAcylation promotes pancreatic tumor growth by regulating malate dehydrogenase 1, Qiang Zhu, Ruhong Zhou*, Wen Yi*, 2022
- O-GlcNAcylation promotes tumor immune evasion by inhibiting PD-L1 lysosomal degradation, Qiang Zhu, Liming Wu*, Wen Yi*, 2023
- O-GlcNAcylation regulates the methionine cycle to promote pluripotency of stem cells, Qiang Zhu, Wen Yi*, 2020
- Chemistry-Assisted Proteomic Profiling of O-GlcNAcylation, Qiang Zhu, Wen Yi*, 2021
- One-Step Enzymatic Labeling Reveals a Critical Role of O-GlcNAcylation in Cell-Cycle Progression and DNA Damage Response, Qiang Zhu, Wen Yi*, 2021
- O-GlcNAcylation of core components of the translation initiation machinery regulates protein synthesis, Qiang Zhu, Wen Yi*, 2019
- Ogt controls neural stem/progenitor cell pool and adult neurogenesis through modulating Notch signaling, Qiang Zhu, Xuekun Li*, Wen Yi*, 2021
- Spatiotemporal Activation of Protein O-GlcNAcylation in Living Cells, Qiang Zhu, Wen Yi*, 2022
- Ogt deficiency induces abnormal cerebellar function and behavioral deficits of adult mice through modulating RhoA/ROCK signaling, Qiang Zhu, Xuekun Li*, Wen Yi, 2023
- O-GlcNAcylation regulates epidermal growth factor receptor intracellular trafficking and signaling, Qiang Zhu, Wen Yi*, 2022
- Ogt-mediated O-GlcNAcylation inhibits astrocytes activation through modulating NF-κB signaling pathway, Qiang Zhu, Wen Yi, Qiang Shu, 2023
Awards
- 2022: Huiyong Zheng Sugar Science Award for Excellent Academic Achievement
- 2020: Second Prize for Excellent Research Paper in Glycoconjugate Specialty
- 2020: Zhejiang Province Outstanding Doctoral Graduate
- 2015: Zhejiang Province Outstanding Undergraduate Graduate
