Professor | Linlin Sun | Asia Growth Partners

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Name	Linlin Sun
Contact Information	linlin.sun@pku.edu.cn
Language ability	Chinese, English
Province	Beijing

Upload Avatar (500 x 500)

Name

Linlin Sun

Contact Information

linlin.sun@pku.edu.cn

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	Peking University
Faculty	Basic Medical Sciences
Academic Background & Achievements	2005-2013: MD-PhD, Peking University (Supervisor: Professor Cui Cailian) Published extensively in neuropathic pain and neuroplasticity
Work Experience	2013.8-2016.7 - Rutgers University, Department of Anesthesiology 2016.7-2018.4 - New York University, Department of Anesthesiology 2018.5-2020.11 - Columbia University, Department of Anesthesiology 2021.1-present - Peking University, Department of Neurobiology, Distinguished Research Fellow

University/Lab Affiliation and Title

Peking University

Faculty

Basic Medical Sciences

Academic Background & Achievements

2005-2013: MD-PhD, Peking University (Supervisor: Professor Cui Cailian)
Published extensively in neuropathic pain and neuroplasticity

Work Experience

2013.8-2016.7 - Rutgers University, Department of Anesthesiology
2016.7-2018.4 - New York University, Department of Anesthesiology
2018.5-2020.11 - Columbia University, Department of Anesthesiology
2021.1-present - Peking University, Department of Neurobiology, Distinguished Research Fellow

Areas of Focus	Mechanisms of chronic neuropathic pain Neuronal synaptic plasticity in drug addiction memory Neural mechanisms of sensory abnormalities and cognitive impairments in autism
Publications	N6-methyladenosine demethylase FTO contributes to neuropathic pain by stabilizing G9a expression in primary sensory neurons, Li, Y., Guo, X., Sun, L., Xiao, J., Su, S., Du, S., Li, Z., Wu, S., Liu, W., Mo, K., Xia, S., Chang, Y., Denis, D., Tao, YX., 2020 Long-term imaging of dorsal root ganglia in awake behaving mice, Chen, C., Zhang, J., Sun, L., Y. Zhang, W. Gan, P. Tang, G. Yang., 2019 Experience and sleep-dependent synaptic plasticity: from structure to activity, Sun, L., Zhou, H., Cichon, J., Yang, G., 2019 Contribution of DNMT1 to neuropathic pain genesis partially through epigenetically repressing Kcna2 in primary afferent neurons, Sun, L., Gu, X., Z. Pan, X. Guo, J. Liu, F. E. Atianjoh, S. Wu, K. Mo, B. Xu, L. Liang, A. Bekker, Y. X. Tao., 2019 Nerve injury-induced epigenetic silencing of opioid receptors controlled by DNMT3a in primary afferent neurons, Sun, L., J. Y. Zhao, X. Gu, L. Liang, S. Wu, K. Mo, J. Feng, W. Guo, J. Zhang, A. Bekker, X. Zhao, E. J. Nestler, Y. X. Tao., 2017 The CRISPR/Cas9 system for gene editing and its potential application in pain research, Sun, L., B. M. Lutz, Y. X. Tao, 2016 Mesoaccumbens dopamine signaling alteration underlies behavioral transition from tolerance to sensitization to morphine rewarding properties during morphine withdrawal, Sun, L., Hu, L., Li, Y., Cui, C., 2013 Dorsal root ganglion myeloid zinc finger protein 1 contributes to neuropathic pain after peripheral nerve trauma, Li, Z., Gu, X., Sun, L., S. Wu, L. Liang, J. Cao, B. M. Lutz, A. Bekker, W. Zhang, Y. X. Tao., 2015 Imaging neuronal activity in the central and peripheral nervous systems using new Thy1.2-GCaMP6 transgenic mouse lines, Cichon, J., J. Magrane, E. Shtridler, C. Chen, Sun. L, G. Yang, W. B. Gan, 2020 Inefficient thermogenic mitochondrial respiration due to futile proton leak in a mouse model of fragile X syndrome, Griffiths, K. K., A. Wang, L. Wang, M. Tracey, G. Kleiner, C. M. Quinzii, Sun. L, G. Yang, J. F. Perez-Zoghbi, P. Licznerski, M. Yang, E. A. Jonas, R. J. Levy, 2020 A Novel Tmem119-tdTomato Reporter Mouse Model for Studying Microglia in the Central Nervous System, Ruan, C., Sun, L., Kroshilina, A., Beckers, L., De Jager, P., Bradshaw, E., Hasson, L., Yang, G., Elyaman, W., 2020 DNMT3a-triggered downregulation of K2p 1.1 gene in primary sensory neurons contributes to paclitaxel-induced neuropathic pain, Mao, Q., S. Wu, X. Gu, S. Du, K. Mo, Sun, L., J. Cao, A. Bekker, L. Chen, Y. X. Tao., 2019 Spared Nerve Injury Model of Neuropathic Pain in Mice, Cichon, J., Sun, L., Yang, G., 2018 AMPA Receptor in Ventromedial Prefrontal Cortex Plays Different Roles in the Recent and Remote Retrieval of Morphine-Associated Memory, Sun, X., Wang, N., Wang, X., Sun, L., Li, Y., Cui, C., 2019 Role of Glutamatergic Projections from the Ventral CA1 to Infralimbic Cortex in Context-Induced Reinstatement of Heroin Seeking, Wang, N., F. Ge, C. Cui, Y. Li, X. Sun, L. Sun, X. Wang, S. Liu, H. Zhang, Y. Liu, M. Jia, M. Yang., 2018 DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons, Zhao, J. Y., L. Liang, X. Gu, Z. Li, S. Wu, L. Sun, F. E. Atianjoh, J. Feng, K. Mo, S. Jia, B. M. Lutz, A. Bekker, E. J. Nestler, Y. X. Tao., 2017 Intrathecal rapamycin attenuates morphine-induced analgesic tolerance and hyperalgesia in rats with neuropathic pain, Xu, J. T., L. Sun, B. M. Lutz, A. Bekker, Y. X. Tao., 2016 Re-exposure to morphine-associated context facilitated long-term potentiation in the vSUB-NAc glutamatergic pathway via GluN2B-containing receptor activation, Li, Y. J., X. J. Ping, C. Qi, F. Shen, L. L. Sun, X. W. Sun, F. F. Ge, G. G. Xing, C. L. Cui., 2015 NAc Shell Arc/Arg3.1 Protein Mediates Reconsolidation of Morphine CPP by Increased GluR1 Cell Surface Expression: Activation of ERK-Coupled CREB is Required, Lv, X. F., L.L. Sun, C. L. Cui, J. S. Han., 2015 Electroacupuncture treatment reverses morphine-induced physiological changes in dopaminergic neurons within the ventral tegmental area, Hu, L., N. N. Chu, L. L. Sun, R. Zhang, J. S. Han, C. L. Cui., 2009

Areas of Focus

Mechanisms of chronic neuropathic pain
Neuronal synaptic plasticity in drug addiction memory
Neural mechanisms of sensory abnormalities and cognitive impairments in autism

Publications

N6-methyladenosine demethylase FTO contributes to neuropathic pain by stabilizing G9a expression in primary sensory neurons, Li, Y., Guo, X., Sun, L., Xiao, J., Su, S., Du, S., Li, Z., Wu, S., Liu, W., Mo, K., Xia, S., Chang, Y., Denis, D., Tao, YX., 2020
Long-term imaging of dorsal root ganglia in awake behaving mice, Chen, C., Zhang, J., Sun, L., Y. Zhang, W. Gan, P. Tang, G. Yang., 2019
Experience and sleep-dependent synaptic plasticity: from structure to activity, Sun, L., Zhou, H., Cichon, J., Yang, G., 2019
Contribution of DNMT1 to neuropathic pain genesis partially through epigenetically repressing Kcna2 in primary afferent neurons, Sun, L., Gu, X., Z. Pan, X. Guo, J. Liu, F. E. Atianjoh, S. Wu, K. Mo, B. Xu, L. Liang, A. Bekker, Y. X. Tao., 2019
Nerve injury-induced epigenetic silencing of opioid receptors controlled by DNMT3a in primary afferent neurons, Sun, L., J. Y. Zhao, X. Gu, L. Liang, S. Wu, K. Mo, J. Feng, W. Guo, J. Zhang, A. Bekker, X. Zhao, E. J. Nestler, Y. X. Tao., 2017
The CRISPR/Cas9 system for gene editing and its potential application in pain research, Sun, L., B. M. Lutz, Y. X. Tao, 2016
Mesoaccumbens dopamine signaling alteration underlies behavioral transition from tolerance to sensitization to morphine rewarding properties during morphine withdrawal, Sun, L., Hu, L., Li, Y., Cui, C., 2013
Dorsal root ganglion myeloid zinc finger protein 1 contributes to neuropathic pain after peripheral nerve trauma, Li, Z., Gu, X., Sun, L., S. Wu, L. Liang, J. Cao, B. M. Lutz, A. Bekker, W. Zhang, Y. X. Tao., 2015
Imaging neuronal activity in the central and peripheral nervous systems using new Thy1.2-GCaMP6 transgenic mouse lines, Cichon, J., J. Magrane, E. Shtridler, C. Chen, Sun. L, G. Yang, W. B. Gan, 2020
Inefficient thermogenic mitochondrial respiration due to futile proton leak in a mouse model of fragile X syndrome, Griffiths, K. K., A. Wang, L. Wang, M. Tracey, G. Kleiner, C. M. Quinzii, Sun. L, G. Yang, J. F. Perez-Zoghbi, P. Licznerski, M. Yang, E. A. Jonas, R. J. Levy, 2020
A Novel Tmem119-tdTomato Reporter Mouse Model for Studying Microglia in the Central Nervous System, Ruan, C., Sun, L., Kroshilina, A., Beckers, L., De Jager, P., Bradshaw, E., Hasson, L., Yang, G., Elyaman, W., 2020
DNMT3a-triggered downregulation of K2p 1.1 gene in primary sensory neurons contributes to paclitaxel-induced neuropathic pain, Mao, Q., S. Wu, X. Gu, S. Du, K. Mo, Sun, L., J. Cao, A. Bekker, L. Chen, Y. X. Tao., 2019
Spared Nerve Injury Model of Neuropathic Pain in Mice, Cichon, J., Sun, L., Yang, G., 2018
AMPA Receptor in Ventromedial Prefrontal Cortex Plays Different Roles in the Recent and Remote Retrieval of Morphine-Associated Memory, Sun, X., Wang, N., Wang, X., Sun, L., Li, Y., Cui, C., 2019
Role of Glutamatergic Projections from the Ventral CA1 to Infralimbic Cortex in Context-Induced Reinstatement of Heroin Seeking, Wang, N., F. Ge, C. Cui, Y. Li, X. Sun, L. Sun, X. Wang, S. Liu, H. Zhang, Y. Liu, M. Jia, M. Yang., 2018
DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons, Zhao, J. Y., L. Liang, X. Gu, Z. Li, S. Wu, L. Sun, F. E. Atianjoh, J. Feng, K. Mo, S. Jia, B. M. Lutz, A. Bekker, E. J. Nestler, Y. X. Tao., 2017
Intrathecal rapamycin attenuates morphine-induced analgesic tolerance and hyperalgesia in rats with neuropathic pain, Xu, J. T., L. Sun, B. M. Lutz, A. Bekker, Y. X. Tao., 2016
Re-exposure to morphine-associated context facilitated long-term potentiation in the vSUB-NAc glutamatergic pathway via GluN2B-containing receptor activation, Li, Y. J., X. J. Ping, C. Qi, F. Shen, L. L. Sun, X. W. Sun, F. F. Ge, G. G. Xing, C. L. Cui., 2015
NAc Shell Arc/Arg3.1 Protein Mediates Reconsolidation of Morphine CPP by Increased GluR1 Cell Surface Expression: Activation of ERK-Coupled CREB is Required, Lv, X. F., L.L. Sun, C. L. Cui, J. S. Han., 2015
Electroacupuncture treatment reverses morphine-induced physiological changes in dopaminergic neurons within the ventral tegmental area, Hu, L., N. N. Chu, L. L. Sun, R. Zhang, J. S. Han, C. L. Cui., 2009

Neuropathic Pain Central Mechanisms Peripheral Mechanisms Synaptic Plasticity Molecular Mechanisms Drug Addiction Memory Formation Autism Sensory Abnormalities Cognitive Impairments

Qiumin Le - Fudan University

Xing Liu - Fudan University

Lan Ma - Fudan University

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