Professor | Xiaojuan Du | Asia Growth Partners

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Name	Xiaojuan Du
Contact Information	duxiaojuan100@bjmu.edu.cn
Language ability	Chinese, German
Province	Beijing

Upload Avatar (500 x 500)

Name

Xiaojuan Du

Contact Information

duxiaojuan100@bjmu.edu.cn

Language ability

Chinese, German

Province

Beijing

University/Lab Affiliation and Title	Peking University
Faculty	Basic Medical Sciences
Academic Background & Achievements	1998-2001: PhD in Biology, University of Freiburg, Germany 1988-1991: Master in Biochemistry and Immunology, Capital Institute of Pediatrics 1982-1988: Bachelor in Clinical Medicine, Beijing Medical University
Work Experience	2011.08-present: Professor, Doctoral Supervisor, Department of Cell Biology, Peking University Health Science Center 2001.10-2011.07: Associate Professor, Department of Cell Biology, Peking University Health Science Center 1995.10-1998.06: Associate Researcher, Biochemistry and Immunology, Capital Institute of Pediatrics 1993.10-1995.09: Assistant Researcher, Biochemistry and Immunology, Capital Institute of Pediatrics 1991.09-1993.09: Intern Researcher, Biochemistry and Immunology, Capital Institute of Pediatrics

University/Lab Affiliation and Title

Peking University

Faculty

Basic Medical Sciences

Academic Background & Achievements

1998-2001: PhD in Biology, University of Freiburg, Germany
1988-1991: Master in Biochemistry and Immunology, Capital Institute of Pediatrics
1982-1988: Bachelor in Clinical Medicine, Beijing Medical University

Work Experience

2011.08-present: Professor, Doctoral Supervisor, Department of Cell Biology, Peking University Health Science Center
2001.10-2011.07: Associate Professor, Department of Cell Biology, Peking University Health Science Center
1995.10-1998.06: Associate Researcher, Biochemistry and Immunology, Capital Institute of Pediatrics
1993.10-1995.09: Assistant Researcher, Biochemistry and Immunology, Capital Institute of Pediatrics
1991.09-1993.09: Intern Researcher, Biochemistry and Immunology, Capital Institute of Pediatrics

Areas of Focus	Mechanisms and functions of tumor-related proteins
Publications	PPP1R26 drives hepatocellular carcinoma progression by controlling glycolysis and epithelial-mesenchymal transition, Yang Yang, Pengwei Ren, Xiaofeng Liu, Xiaoyan Sun, Chunfeng Zhang, Xiaojuan Du, Baocai Xing, 2022 NAT10 regulates mitotic cell fate by acetylating Eg5 to control bipolar spindle assembly and chromosome segregation, Jiaojiao Zheng, Yuqin Tan, Xiaofeng Liu, Chunfeng Zhang, Kunqi Su, Yang Jiang, Jianyuan Luo, Li Li, Xiaojuan Du, 2022 Sec62 promotes stemness and chemoresistance of human colorectal cancer through activating Wnt/β-catenin pathway, Xiaofeng Liu, Kunqi Su, Xiaoyan Sun, Yang Jiang, Lijun Wang, Chenyu Hu, Chunfeng Zhang, Min Lu, Xiaojuan Du, Baocai Xing, 2021 p21-activated kinase 6 controls mitosis and hepatocellular carcinoma progression by regulating Eg5, Jiaojiao Zheng, Chunfeng Zhang, Yuan Li, Yang Jiang, Baocai Xing, Xiaojuan Du, 2021 NIR promotes progression of colorectal cancer through regulating RB, Yuan Li, Ling Wang, Xiaofeng Liu, Chunfeng Zhang, Xiaojuan Du, Baocai Xing, 2021 MiR-6716-5p promotes metastasis of colorectal cancer through downregulating NAT10 expression, Zhenzhen Liu, Xiaofeng Liu, Yuan Li, Pengwei Ren, Chunfeng Zhang, Lijun Wang, Xiaojuan Du, Baocai Xing, 2019 Human UTP14a promotes angiogenesis through upregulating PDGFA expression in colorectal cancer, Ren P, Sun X, Zhang C, Wang L, Xing B, Du X, 2019 Human UTP14a promotes colorectal cancer progression by forming a positive regulation loop with c-Myc, Jingyi Zhang, Pengwei Ren, Da Xu, Xiaofeng Liu, Zhenzhen Liu, Chunfeng Zhang, Yuan Lia, Lijun Wanga, Xiaojuan Du, Baocai Xing, 2019 Deacetylation of NAT10 by Sirt1 promotes the transition from rRNA biogenesis to autophagy upon energy stress, Xiaofeng Liu, Shiying Cai, Chunfeng Zhang, Zhenzhen Liu, Jianyuan Luo, Baocai Xing, Xiaojuan Du, 2018 NRBE3 promotes metastasis of breast cancer by down-regulating E-cadherin expression, Tong Zheng, Min Lu, Ting Wang, Chunfeng Zhang, Xiaojuan Du, 2018 Human U3 protein14a is a novel type ubiquitin ligase that binds RB and promotes RB degradation depending on a Leucine-rich region, Huijiao Liu, Jiangnan Wang, Yun Liu, Min Lu, Lelin Hu, Chunfeng Zhang, Baocai Xing, Xiaojuan Du, 2018 Loss of nucleolar localization of NAT10 promotes cell migration and invasion in hepatocellular carcinoma, Yuqin Tan, Jiaojiao Zheng, Xiaofeng Liu, Min Lu, Chunfeng Zhang, Baocai Xing, Xiaojuan Du, 2018 Human U3 protein 14a plays an anti-apoptotic role in cancer cells, Ma T, Lu C, Guo Y, Zhang C, Du X, 2017 Autoacetylation of NAT10 is critical for its function in rRNA transcription activation, Cai S, Liu X, Zhang C, Xing B, Du X, 2017 NAT10 regulates p53 activation through acetylating p53 at K120 and ubiquitinating Mdm2, Liu X, Tan Y, Zhang C, Zhang Y, Zhang L, Ren P, Deng H, Luo J, Ke Y, Du X, 2016 A novel retinoblastoma protein (RB) E3 ubiquitin Ligase (NRBE3) Promotes RB degradation and is transcriptionally regulated by E2F1 transcription factor, Wang Y, Zheng Z, Zhang J, Wang Y, Kong R, Liu J, Zhang Y, Deng H, Du X, Ke Y, 2015 N-WASP is highly expressed in hepatocellular carcinoma and associated with poor prognosis, Jin K, Liu F, Gu J, Du X and Xing B, 2013 AIB1 as an independent prognostic marker in hepatocellular carcinoma after Hepatic Resection, Song J, Lu M, Liu F, Du X and Xing B, 2012 hALP, A novel t-UTP, activates polymerase I transcription by binding and acetylating the upstream binding factor, Kong R, Zhang L, Hu L, Peng Q, Han W, Du X and Ke Y, 2011 A small ribosomal subunit (SSU) processome component, the human U three protein 14a binds p53 and promotes p53 degradation, Hu L, Wang J, Zhang L, Kong R, Zheng Z, Han W, Du X and Ke Y*, 2011

Areas of Focus

Mechanisms and functions of tumor-related proteins

Publications

PPP1R26 drives hepatocellular carcinoma progression by controlling glycolysis and epithelial-mesenchymal transition, Yang Yang, Pengwei Ren, Xiaofeng Liu, Xiaoyan Sun, Chunfeng Zhang, Xiaojuan Du*, Baocai Xing*, 2022
NAT10 regulates mitotic cell fate by acetylating Eg5 to control bipolar spindle assembly and chromosome segregation, Jiaojiao Zheng, Yuqin Tan, Xiaofeng Liu, Chunfeng Zhang, Kunqi Su, Yang Jiang, Jianyuan Luo, Li Li*, Xiaojuan Du*, 2022
Sec62 promotes stemness and chemoresistance of human colorectal cancer through activating Wnt/β-catenin pathway, Xiaofeng Liu, Kunqi Su, Xiaoyan Sun, Yang Jiang, Lijun Wang, Chenyu Hu, Chunfeng Zhang, Min Lu, Xiaojuan Du*, Baocai Xing*, 2021
p21-activated kinase 6 controls mitosis and hepatocellular carcinoma progression by regulating Eg5, Jiaojiao Zheng, Chunfeng Zhang, Yuan Li, Yang Jiang, Baocai Xing*, Xiaojuan Du*, 2021
NIR promotes progression of colorectal cancer through regulating RB, Yuan Li, Ling Wang, Xiaofeng Liu, Chunfeng Zhang, Xiaojuan Du*, Baocai Xing*, 2021
MiR-6716-5p promotes metastasis of colorectal cancer through downregulating NAT10 expression, Zhenzhen Liu, Xiaofeng Liu, Yuan Li, Pengwei Ren, Chunfeng Zhang, Lijun Wang, Xiaojuan Du*, Baocai Xing*, 2019
Human UTP14a promotes angiogenesis through upregulating PDGFA expression in colorectal cancer, Ren P, Sun X, Zhang C, Wang L, Xing B, Du X*, 2019
Human UTP14a promotes colorectal cancer progression by forming a positive regulation loop with c-Myc, Jingyi Zhang, Pengwei Ren, Da Xu, Xiaofeng Liu, Zhenzhen Liu, Chunfeng Zhang, Yuan Lia, Lijun Wanga, Xiaojuan Du*, Baocai Xing*, 2019
Deacetylation of NAT10 by Sirt1 promotes the transition from rRNA biogenesis to autophagy upon energy stress, Xiaofeng Liu, Shiying Cai, Chunfeng Zhang, Zhenzhen Liu, Jianyuan Luo, Baocai Xing*, Xiaojuan Du*, 2018
NRBE3 promotes metastasis of breast cancer by down-regulating E-cadherin expression, Tong Zheng, Min Lu, Ting Wang, Chunfeng Zhang, Xiaojuan Du*, 2018
Human U3 protein14a is a novel type ubiquitin ligase that binds RB and promotes RB degradation depending on a Leucine-rich region, Huijiao Liu, Jiangnan Wang, Yun Liu, Min Lu, Lelin Hu, Chunfeng Zhang, Baocai Xing, Xiaojuan Du*, 2018
Loss of nucleolar localization of NAT10 promotes cell migration and invasion in hepatocellular carcinoma, Yuqin Tan, Jiaojiao Zheng, Xiaofeng Liu, Min Lu, Chunfeng Zhang, Baocai Xing, Xiaojuan Du*, 2018
Human U3 protein 14a plays an anti-apoptotic role in cancer cells, Ma T, Lu C, Guo Y, Zhang C, Du X*, 2017
Autoacetylation of NAT10 is critical for its function in rRNA transcription activation, Cai S, Liu X, Zhang C, Xing B, Du X*, 2017
NAT10 regulates p53 activation through acetylating p53 at K120 and ubiquitinating Mdm2, Liu X, Tan Y, Zhang C, Zhang Y, Zhang L, Ren P, Deng H, Luo J, Ke Y, Du X*, 2016
A novel retinoblastoma protein (RB) E3 ubiquitin Ligase (NRBE3) Promotes RB degradation and is transcriptionally regulated by E2F1 transcription factor, Wang Y, Zheng Z, Zhang J, Wang Y, Kong R, Liu J, Zhang Y, Deng H, Du X*, Ke Y*, 2015
N-WASP is highly expressed in hepatocellular carcinoma and associated with poor prognosis, Jin K, Liu F, Gu J, Du X* and Xing B*, 2013
AIB1 as an independent prognostic marker in hepatocellular carcinoma after Hepatic Resection, Song J, Lu M, Liu F, Du X* and Xing B*, 2012
hALP, A novel t-UTP, activates polymerase I transcription by binding and acetylating the upstream binding factor, Kong R, Zhang L, Hu L, Peng Q, Han W, Du X* and Ke Y*, 2011
A small ribosomal subunit (SSU) processome component, the human U three protein 14a binds p53 and promotes p53 degradation, Hu L, Wang J, Zhang L, Kong R, Zheng Z, Han W, Du X* and Ke Y*, 2011

Tumor Proteins Cell Division Metabolism Drug Resistance Metastasis Dna Damage Acetylation Autophagy Microtubule

Ying Zhao - Peking University

Honglei Chen - Wuhan University

Wei Liu - Zhejiang University

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