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Xiaojuan Du
Basic Medical Sciences
Peking University
Beijing
Language: Chinese, German
Tumor
Proteins
Cell Division
Metabolism
Drug Resistance
Metastasis
Dna Damage
Acetylation
Autophagy
Microtubule
Areas of Focus
- Mechanisms and functions of tumor-related proteins
Work Experience
- 2011.08-present: Professor, Doctoral Supervisor, Department of Cell Biology, Peking University Health Science Center
- 2001.10-2011.07: Associate Professor, Department of Cell Biology, Peking University Health Science Center
- 1995.10-1998.06: Associate Researcher, Biochemistry and Immunology, Capital Institute of Pediatrics
- 1993.10-1995.09: Assistant Researcher, Biochemistry and Immunology, Capital Institute of Pediatrics
- 1991.09-1993.09: Intern Researcher, Biochemistry and Immunology, Capital Institute of Pediatrics
Academic Background & Achievements
- 1998-2001: PhD in Biology, University of Freiburg, Germany
- 1988-1991: Master in Biochemistry and Immunology, Capital Institute of Pediatrics
- 1982-1988: Bachelor in Clinical Medicine, Beijing Medical University
Publications
- PPP1R26 drives hepatocellular carcinoma progression by controlling glycolysis and epithelial-mesenchymal transition, Yang Yang, Pengwei Ren, Xiaofeng Liu, Xiaoyan Sun, Chunfeng Zhang, Xiaojuan Du*, Baocai Xing*, 2022
- NAT10 regulates mitotic cell fate by acetylating Eg5 to control bipolar spindle assembly and chromosome segregation, Jiaojiao Zheng, Yuqin Tan, Xiaofeng Liu, Chunfeng Zhang, Kunqi Su, Yang Jiang, Jianyuan Luo, Li Li*, Xiaojuan Du*, 2022
- Sec62 promotes stemness and chemoresistance of human colorectal cancer through activating Wnt/β-catenin pathway, Xiaofeng Liu, Kunqi Su, Xiaoyan Sun, Yang Jiang, Lijun Wang, Chenyu Hu, Chunfeng Zhang, Min Lu, Xiaojuan Du*, Baocai Xing*, 2021
- p21-activated kinase 6 controls mitosis and hepatocellular carcinoma progression by regulating Eg5, Jiaojiao Zheng, Chunfeng Zhang, Yuan Li, Yang Jiang, Baocai Xing*, Xiaojuan Du*, 2021
- NIR promotes progression of colorectal cancer through regulating RB, Yuan Li, Ling Wang, Xiaofeng Liu, Chunfeng Zhang, Xiaojuan Du*, Baocai Xing*, 2021
- MiR-6716-5p promotes metastasis of colorectal cancer through downregulating NAT10 expression, Zhenzhen Liu, Xiaofeng Liu, Yuan Li, Pengwei Ren, Chunfeng Zhang, Lijun Wang, Xiaojuan Du*, Baocai Xing*, 2019
- Human UTP14a promotes angiogenesis through upregulating PDGFA expression in colorectal cancer, Ren P, Sun X, Zhang C, Wang L, Xing B, Du X*, 2019
- Human UTP14a promotes colorectal cancer progression by forming a positive regulation loop with c-Myc, Jingyi Zhang, Pengwei Ren, Da Xu, Xiaofeng Liu, Zhenzhen Liu, Chunfeng Zhang, Yuan Lia, Lijun Wanga, Xiaojuan Du*, Baocai Xing*, 2019
- Deacetylation of NAT10 by Sirt1 promotes the transition from rRNA biogenesis to autophagy upon energy stress, Xiaofeng Liu, Shiying Cai, Chunfeng Zhang, Zhenzhen Liu, Jianyuan Luo, Baocai Xing*, Xiaojuan Du*, 2018
- NRBE3 promotes metastasis of breast cancer by down-regulating E-cadherin expression, Tong Zheng, Min Lu, Ting Wang, Chunfeng Zhang, Xiaojuan Du*, 2018
- Human U3 protein14a is a novel type ubiquitin ligase that binds RB and promotes RB degradation depending on a Leucine-rich region, Huijiao Liu, Jiangnan Wang, Yun Liu, Min Lu, Lelin Hu, Chunfeng Zhang, Baocai Xing, Xiaojuan Du*, 2018
- Loss of nucleolar localization of NAT10 promotes cell migration and invasion in hepatocellular carcinoma, Yuqin Tan, Jiaojiao Zheng, Xiaofeng Liu, Min Lu, Chunfeng Zhang, Baocai Xing, Xiaojuan Du*, 2018
- Human U3 protein 14a plays an anti-apoptotic role in cancer cells, Ma T, Lu C, Guo Y, Zhang C, Du X*, 2017
- Autoacetylation of NAT10 is critical for its function in rRNA transcription activation, Cai S, Liu X, Zhang C, Xing B, Du X*, 2017
- NAT10 regulates p53 activation through acetylating p53 at K120 and ubiquitinating Mdm2, Liu X, Tan Y, Zhang C, Zhang Y, Zhang L, Ren P, Deng H, Luo J, Ke Y, Du X*, 2016
- A novel retinoblastoma protein (RB) E3 ubiquitin Ligase (NRBE3) Promotes RB degradation and is transcriptionally regulated by E2F1 transcription factor, Wang Y, Zheng Z, Zhang J, Wang Y, Kong R, Liu J, Zhang Y, Deng H, Du X*, Ke Y*, 2015
- N-WASP is highly expressed in hepatocellular carcinoma and associated with poor prognosis, Jin K, Liu F, Gu J, Du X* and Xing B*, 2013
- AIB1 as an independent prognostic marker in hepatocellular carcinoma after Hepatic Resection, Song J, Lu M, Liu F, Du X* and Xing B*, 2012
- hALP, A novel t-UTP, activates polymerase I transcription by binding and acetylating the upstream binding factor, Kong R, Zhang L, Hu L, Peng Q, Han W, Du X* and Ke Y*, 2011
- A small ribosomal subunit (SSU) processome component, the human U three protein 14a binds p53 and promotes p53 degradation, Hu L, Wang J, Zhang L, Kong R, Zheng Z, Han W, Du X* and Ke Y*, 2011
