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Peipei Zhang
Basic Medical Sciences
Peking University
Beijing
Language: Chinese, English
Neurodegenerative Diseases
Pathogenesis
Membrane-Less Organelles
Biomolecular Condensates
Phase Separation
Stress Granules
Protein Aggregation
Als
Ftd
Cellular Dynamics
Areas of Focus
- Pathogenesis of neurodegenerative diseases and regulation mechanisms of membrane-less organelles
Work Experience
- 2014-2021 - St. Jude Children’s Research Hospital, Postdoctoral Researcher
Academic Background & Achievements
- 2014 - PhD in Biochemistry and Molecular Biology: Joint training program between Beijing Normal University and National Institute of Biological Sciences, Beijing
Publications
- Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology, Peipei Zhang et al., 2019
- C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles, Peipei Zhang et al., 2016
- Autophagy modulates miRNA-mediated gene silencing and selectively degrades AIN-1/GW182 in C. elegans, Peipei Zhang et al., 2013
- Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specific manner, Peipei Zhang et al., 2021
- G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules, Peipei Zhang et al., 2020
- C9orf72 poly(PR) Dipeptide Repeats Disturb Biomolecular Phase Separation and Disrupt Nucleolar Function, Peipei Zhang et al., 2019
- Genetic interaction of hnRNPA2B1 and DNAJB6 in a Drosophila model of multisystem proteinopathy, Peipei Zhang et al., 2016
