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Jun Chen
Basic Medical Sciences
Peking University
Beijing
Language: Chinese, English
Senescence-Associated Secretory Phenotype
Telomerase Complex Assembly
P16 Gene Regulation
Rna-Binding Proteins
Cellular Aging
Small Molecules
Aging Delay
Age-Related Diseases
Molecular Intervention
Cell Proliferation
Areas of Focus
- Molecular mechanisms of cellular aging
- Intervention of aging with small molecule compounds
Publications
- HnRNP F/H associate with hTERC and telomerase holoenzyme to modulate telomerase function and promote cell proliferation, Jun Chen et al., 2020
- Protein kinase D1 phosphorylation of KAT7 enhances its protein stability and promotes replication licensing and cell proliferation, Jun Chen et al., 2020
- Long-term every-other-day administration of DMAMCL has little effect on aging and age-associated physiological decline in mice, Jun Chen et al., 2019
- S100A13 promotes senescence-associated secretory phenotype and cellular senescence via modulation of non-classical secretion of IL-1α, Jun Chen et al., 2019
- Protein kinase D1-mediated classical protein secretory pathway regulates oncogene Ras-induced senescent response, Jun Chen et al., 2018
- hnRNP A1 antagonizes cellular senescence and senescence-associated secretory phenotype via regulation of SIRT1 mRNA stability, Jun Chen et al., 2016
- Protein kinase D1 is essential for Ras-induced senescence and tumor suppression by regulating senescence-associated inflammation, Jun Chen et al., 2014
Awards
- National Natural Science Foundation of China (2014, 2016, 2019, 2021)
- Key Research and Development Program of the Ministry of Science and Technology, Core Member (2018)
