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Bai
Basic Medical Sciences
Peking University
Beijing
Language: English, Chinese
Cryo-Electron Microscopy
Biochemistry
Biophysics
Fungal Targets
Drug Development
Antifungal Drugs
Structural Research
Functional Research
Drug Targets
Medicinal Chemistry
Areas of Focus
- Structural and functional research of fungal drug targets using cryo-electron microscopy and other biochemical and biophysical methods
- Development of antifungal drugs based on structure
Work Experience
- 2012.8-2016.7 - Brookhaven National Laboratory, USA - Postdoctoral Researcher
- 2016.7-2020.8 - Van Andel Research Institute, USA - Senior Research Scientist
- 2020.9-present - Peking University, School of Basic Medical Sciences - Researcher
Academic Background & Achievements
- 2002.9-2006.7 Bachelor of Science: Lanzhou University, School of Life Sciences
- 2006.9-2012.8 PhD in Biochemistry and Molecular Biology: Institute of Biophysics, Chinese Academy of Sciences
- Led national natural science foundation projects and national overseas high-level talent projects.
Publications
- Structure of a fungal 1,3-β-glucan synthase, Zhao C, You Z, Chen D, Hang J, Wang Z, Wang L, Zhao P, Qiao J, Yun C, Bai L, 2023
- Structure, catalysis, chitin transport, and selective inhibition of chitin synthase, Chen D, Wang Z, Wang L, Zhao P, Yun C, Bai L, 2023
- Structure and activation mechanism of the hexameric plasma membrane H+-ATPase, Zhao P, Zhao C, Chen D, Yun C, Li H, Bai L, 2021
- Structural basis of the P4B ATPase lipid flippase activity, Bai L, Jain BK, You Q, Duan HD, Takar M, Graham TR, Li H, 2021
- Transport mechanism of P4 ATPase phosphatidylcholine flippases, Bai L, You Q, Jain BK, Duan HD, Kovach A, Graham TR, Li H, 2020
- Structure of the ER membrane complex, a transmembrane-domain insertase, Bai L, Kovach A, You Q, Hsu HC, Zhao G, Li H, 2020
- Atomic structure of the eukaryotic lipid flippase Drs2p-Cdc50p, Bai L, Kovach A, You Q, Kenny A, Li H, 2019
- Structure of the eukaryotic protein O-mannosyltransferase Pmt1-Pmt2 complex, Bai L, Wang T, Zhao G, Kovach A, Li H, 2019
- The atomic structure of a eukaryotic oligosaccharyl transferase complex, Bai L, Wang T, Zhao G, Kovach A, Li H, 2018
- Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes, Santos RLA, Bai L, Singh PK, Murakami N, Fan H, Zhan W, Zhu Y, Jiang X, Zhang K, Assker JP, Nathan CF, Li H, Azzi J, Lin G, 2017
- Cryo-EM structure of Mcm2-7 double hexamer on DNA suggests a lagging-strand DNA extrusion model, Noguchi Y, Yuan Z, Bai L, Schneider S, Zhao G, Stillman B, Speck C, Li H, 2017
- Structural Analysis of Mycobacterium tuberculosis Homologues of the Eukaryotic Proteasome Assembly Chaperone 2 (PAC2), Bai L, Jastrab JB, Isasa M, Hu K, Yu H, Gygi SP, Darwin KH, Li H, 2017
- Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1, Yuan Z, Riera A, Bai L, Sun J, Nandi S, Spanos C, Chen ZA, Barbon M, Rappsilber J, Stillman B, Speck C, Li H, 2017
- Structure of eukaryotic CMG helicase at a replication fork and implications to replisome architecture and origin initiation, Georgescu R, Yuan Z, Bai L, de Luna Almeida Santos R, Sun J, Zhang D, Yurieva O, Li H, O'Donnell ME, 2017
- Structural analysis of the dodecameric proteasome activator PafE in Mycobacterium tuberculosis, Bai L, Hu K, Wang T, Jastrab JB, Darwin KH, Li H, 2016
- Crystal structure and functional implication of the RUN domain of human NESCA, Sun Q, Han C, Liu L, Wang Y, Deng H, Bai L, Jiang T, 2012
- Crystal structure of the carnitine transporter and insights into the antiport mechanism, Tang L, Bai L, Wang WH, Jiang T, 2010
