Professor | Bai | Asia Growth Partners

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Name	Bai
Contact Information	lbai@pku.edu.cn
Language ability	English, Chinese
Province	Beijing

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Name

Bai

Contact Information

lbai@pku.edu.cn

Language ability

English, Chinese

Province

Beijing

University/Lab Affiliation and Title	Peking University
Faculty	Basic Medical Sciences
Academic Background & Achievements	2002.9-2006.7 Bachelor of Science: Lanzhou University, School of Life Sciences 2006.9-2012.8 PhD in Biochemistry and Molecular Biology: Institute of Biophysics, Chinese Academy of Sciences Led national natural science foundation projects and national overseas high-level talent projects.
Work Experience	2012.8-2016.7 - Brookhaven National Laboratory, USA - Postdoctoral Researcher 2016.7-2020.8 - Van Andel Research Institute, USA - Senior Research Scientist 2020.9-present - Peking University, School of Basic Medical Sciences - Researcher

University/Lab Affiliation and Title

Peking University

Faculty

Basic Medical Sciences

Academic Background & Achievements

2002.9-2006.7 Bachelor of Science: Lanzhou University, School of Life Sciences
2006.9-2012.8 PhD in Biochemistry and Molecular Biology: Institute of Biophysics, Chinese Academy of Sciences
Led national natural science foundation projects and national overseas high-level talent projects.

Work Experience

2012.8-2016.7 - Brookhaven National Laboratory, USA - Postdoctoral Researcher
2016.7-2020.8 - Van Andel Research Institute, USA - Senior Research Scientist
2020.9-present - Peking University, School of Basic Medical Sciences - Researcher

Areas of Focus	Structural and functional research of fungal drug targets using cryo-electron microscopy and other biochemical and biophysical methods Development of antifungal drugs based on structure
Publications	Structure of a fungal 1,3-β-glucan synthase, Zhao C, You Z, Chen D, Hang J, Wang Z, Wang L, Zhao P, Qiao J, Yun C, Bai L, 2023 Structure, catalysis, chitin transport, and selective inhibition of chitin synthase, Chen D, Wang Z, Wang L, Zhao P, Yun C, Bai L, 2023 Structure and activation mechanism of the hexameric plasma membrane H+-ATPase, Zhao P, Zhao C, Chen D, Yun C, Li H, Bai L, 2021 Structural basis of the P4B ATPase lipid flippase activity, Bai L, Jain BK, You Q, Duan HD, Takar M, Graham TR, Li H, 2021 Transport mechanism of P4 ATPase phosphatidylcholine flippases, Bai L, You Q, Jain BK, Duan HD, Kovach A, Graham TR, Li H, 2020 Structure of the ER membrane complex, a transmembrane-domain insertase, Bai L, Kovach A, You Q, Hsu HC, Zhao G, Li H, 2020 Atomic structure of the eukaryotic lipid flippase Drs2p-Cdc50p, Bai L, Kovach A, You Q, Kenny A, Li H, 2019 Structure of the eukaryotic protein O-mannosyltransferase Pmt1-Pmt2 complex, Bai L, Wang T, Zhao G, Kovach A, Li H, 2019 The atomic structure of a eukaryotic oligosaccharyl transferase complex, Bai L, Wang T, Zhao G, Kovach A, Li H, 2018 Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes, Santos RLA, Bai L, Singh PK, Murakami N, Fan H, Zhan W, Zhu Y, Jiang X, Zhang K, Assker JP, Nathan CF, Li H, Azzi J, Lin G, 2017 Cryo-EM structure of Mcm2-7 double hexamer on DNA suggests a lagging-strand DNA extrusion model, Noguchi Y, Yuan Z, Bai L, Schneider S, Zhao G, Stillman B, Speck C, Li H, 2017 Structural Analysis of Mycobacterium tuberculosis Homologues of the Eukaryotic Proteasome Assembly Chaperone 2 (PAC2), Bai L, Jastrab JB, Isasa M, Hu K, Yu H, Gygi SP, Darwin KH, Li H, 2017 Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1, Yuan Z, Riera A, Bai L, Sun J, Nandi S, Spanos C, Chen ZA, Barbon M, Rappsilber J, Stillman B, Speck C, Li H, 2017 Structure of eukaryotic CMG helicase at a replication fork and implications to replisome architecture and origin initiation, Georgescu R, Yuan Z, Bai L, de Luna Almeida Santos R, Sun J, Zhang D, Yurieva O, Li H, O'Donnell ME, 2017 Structural analysis of the dodecameric proteasome activator PafE in Mycobacterium tuberculosis, Bai L, Hu K, Wang T, Jastrab JB, Darwin KH, Li H, 2016 Crystal structure and functional implication of the RUN domain of human NESCA, Sun Q, Han C, Liu L, Wang Y, Deng H, Bai L, Jiang T, 2012 Crystal structure of the carnitine transporter and insights into the antiport mechanism, Tang L, Bai L, Wang WH, Jiang T, 2010

Areas of Focus

Structural and functional research of fungal drug targets using cryo-electron microscopy and other biochemical and biophysical methods
Development of antifungal drugs based on structure

Publications

Structure of a fungal 1,3-β-glucan synthase, Zhao C, You Z, Chen D, Hang J, Wang Z, Wang L, Zhao P, Qiao J, Yun C, Bai L, 2023
Structure, catalysis, chitin transport, and selective inhibition of chitin synthase, Chen D, Wang Z, Wang L, Zhao P, Yun C, Bai L, 2023
Structure and activation mechanism of the hexameric plasma membrane H+-ATPase, Zhao P, Zhao C, Chen D, Yun C, Li H, Bai L, 2021
Structural basis of the P4B ATPase lipid flippase activity, Bai L, Jain BK, You Q, Duan HD, Takar M, Graham TR, Li H, 2021
Transport mechanism of P4 ATPase phosphatidylcholine flippases, Bai L, You Q, Jain BK, Duan HD, Kovach A, Graham TR, Li H, 2020
Structure of the ER membrane complex, a transmembrane-domain insertase, Bai L, Kovach A, You Q, Hsu HC, Zhao G, Li H, 2020
Atomic structure of the eukaryotic lipid flippase Drs2p-Cdc50p, Bai L, Kovach A, You Q, Kenny A, Li H, 2019
Structure of the eukaryotic protein O-mannosyltransferase Pmt1-Pmt2 complex, Bai L, Wang T, Zhao G, Kovach A, Li H, 2019
The atomic structure of a eukaryotic oligosaccharyl transferase complex, Bai L, Wang T, Zhao G, Kovach A, Li H, 2018
Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes, Santos RLA, Bai L, Singh PK, Murakami N, Fan H, Zhan W, Zhu Y, Jiang X, Zhang K, Assker JP, Nathan CF, Li H, Azzi J, Lin G, 2017
Cryo-EM structure of Mcm2-7 double hexamer on DNA suggests a lagging-strand DNA extrusion model, Noguchi Y, Yuan Z, Bai L, Schneider S, Zhao G, Stillman B, Speck C, Li H, 2017
Structural Analysis of Mycobacterium tuberculosis Homologues of the Eukaryotic Proteasome Assembly Chaperone 2 (PAC2), Bai L, Jastrab JB, Isasa M, Hu K, Yu H, Gygi SP, Darwin KH, Li H, 2017
Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1, Yuan Z, Riera A, Bai L, Sun J, Nandi S, Spanos C, Chen ZA, Barbon M, Rappsilber J, Stillman B, Speck C, Li H, 2017
Structure of eukaryotic CMG helicase at a replication fork and implications to replisome architecture and origin initiation, Georgescu R, Yuan Z, Bai L, de Luna Almeida Santos R, Sun J, Zhang D, Yurieva O, Li H, O'Donnell ME, 2017
Structural analysis of the dodecameric proteasome activator PafE in Mycobacterium tuberculosis, Bai L, Hu K, Wang T, Jastrab JB, Darwin KH, Li H, 2016
Crystal structure and functional implication of the RUN domain of human NESCA, Sun Q, Han C, Liu L, Wang Y, Deng H, Bai L, Jiang T, 2012
Crystal structure of the carnitine transporter and insights into the antiport mechanism, Tang L, Bai L, Wang WH, Jiang T, 2010

Cryo-Electron Microscopy Biochemistry Biophysics Fungal Targets Drug Development Antifungal Drugs Structural Research Functional Research Drug Targets Medicinal Chemistry

Bei Li - Fudan University

Lan Wang - Fudan University

Qing Tang - Chongqing Medical University

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