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Yan Zhang
Basic Medical Sciences
Peking University
Beijing
Language: Chinese, English
Cardiovascular
Physiology
Pathophysiology
Myocardial
Cell
Injury
Protection
Mechanisms
Research
Molecular
Areas of Focus
- Cardiovascular physiology and pathophysiology
- Myocardial cell injury and protection mechanisms
Work Experience
- 2020/10 – Present: Researcher, Cardiovascular Research Institute, Peking University
- 2010/10 – 2020/9: Associate Researcher, Institute of Molecular Medicine, Peking University
- 2008/10 – 2010/9: Postdoctoral Fellow, Institute of Molecular Medicine, Peking University
- 2005/10 – 2007/10: Postdoctoral Fellow, Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, USA
Academic Background & Achievements
- 2003/9 – 2008/7 PhD in Physiology, Peking University (Supervisor: Professor Ruiping Xiao)
- 1998/9 – 2003/7 Bachelor in Clinical Medicine, Peking University
- Received 5 National Natural Science Funds, published 54 papers including in high-impact journals like Nature and Cell
Publications
- Structure-based design of non-hypertrophic apelin receptor modulator, Wang WW, Ji SY, Zhang W, Zhang J, Cai C, Hu R, Zang SK, Miao L, Xu H, Chen LN, Yang Z, Guo J, Qin J, Shen DD, Liang P, Zhang Y, Zhang Y, 2024
- Single-cell analysis reveals an Angpt4-initiated EPDC-EC-CM cellular coordination cascade during heart regeneration, Wu Z, Shi Y, Cui Y, Xing X, Zhang L, Liu D, Zhang Y, Dong J, Jin L, Pang M, Xiao RP, Zhu Z, Xiong JW, Tong X, Zhang Y, Wang S, Tang F, Zhang B, 2023
- Refining prediction of stroke in sinus node dysfunction patients without atrial fibrillation using a P-combined score: a multi-centre study, Dong H, Zhang Y, Sun D, Wang G, Zhang Q, Hidru TH, Yang Y, Wang S, Wei Y, Liu F, Zhang J, Xia Y, Yang X, 2023
- Novel CaMKII-δ inhibitor hesperadin exerts dual functions to ameliorate cardiac ischemia/reperfusion injury and inhibit tumor growth, Zhang J, Liang R, Wang K, Zhang W, Zhang M, Jin L, Xie P, Zheng W, Shang H, Hu Q, Li J, Chen G, Wu F, Lan F, Wang L, Wang S.Q., Li Y, Zhang Y, Liu J, Lv F, Hu X, Xiao R.P., Lei X, Zhang Y, 2022
- Targeting CaMKII-δ9 Ameliorates Cardiac Ischemia/reperfusion Injury by Inhibiting Myocardial Inflammation, Yao Y, Li F, Zhang M, Jin L, Xie P, Liu D, Zhang J, Hu X, Lv F, Shang H, Zheng W, Sun X, Duanmu J, Wu F, Lan F, Xiao RP., Zhang Y, 2022
- MG53 E3 ligase-dead mutant protects diabetic hearts from acute ischemic/reperfusion injury and ameliorates diet-induced cardiometabolic damage, Feng H, Shen H, Robeson MJ, Wu YH, Wu HK., Chen GJ, Zhang S, Xie P, Jin L, He Y, Wang Y, Lv F, Hu X, Zhang Y, Xiao RP, 2022
- CaMKII-δ9 induces cardiomyocyte death to promote cardiomyopathy and heart failure, Zhang M, Zhang J, Zhang W, Hu Q, Jin L, Xie P, Zheng W, Shang H, Zhang Y, 2022
- Heterodimerization with 5-HT2BR is indispensable for b2AR-mediated cardioprotection, Song Y, Xu C, Liu J, Li Y, Wang H, Shan D, Wainer I, Hu X, Zhang Y, Woo YH, Xiao RP, 2021
- β-Arrestin2 Inhibits the Apoptosis and Facilitates the Proliferation of Fibroblast-like Synoviocytes in Diffuse-type Tenosynovial Giant Cell Tumor, Cao C, Zhang Y, Cheng J, Wu F, Niu X, Hu X, Duan X, Fu X, Zhang J, Zhang X, Ao Y, 2021
- Cardiac ischemic preconditioning promotes MG53 secretion through H2O2-activated PKC-d signaling, Shan D, Guo S, Wu HK, Lv F, Jin L, Zhang M, Xie P, Wang Y, Song Y, Wu F, Lan F, Hu X, Cao CM, Zhang Y, Xiao RP, 2020
- CaMKII-d9 promotes cardiomyopathy through disrupting UBE2T-dependent DNA repair, Zhang M, Gao H, Liu D, Zhong X, Shi X, Yu P, Jin L, Liu Y, Tang Y, Song Y, Liu J, Hu X, Li CY, Song L, Qin J, Wu F, Lan F, Zhang Y, Xiao RP, 2019
- Glucose-sensitive myokine/cardiokine MG53 regulates systemic insulin response and metabolic homeostasis, Wu HK, Zhang Y, Cao CM, Hu X, Fang M, Yao Y, Jin L, Chen G, Jiang P, Zhang S, Song R, Peng W, Liu F, Guo J, Tang L, He Y, Shan D, Huang J, Zhou Z, Wang D, Lv F, Xiao RP, 2019
- β-arrestin 2 mediates cardiac ischemia-reperfusion injury via inhibiting GPCR-independent cell survival signaling, Wang Y, Jin L, Song Y, Zhang M, Shan D, Liu Y, Lv F, Xiao RP, Zhang Y, 2017
- CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress-induced myocardial necroptosis, Zhang T, Zhang Y, Cui M, Jin L, Wang Y, Lv F, Liu Y, Zheng W, Shang H, Zhang J, Zhang M, Wu HK, Guo J, Zhang X, Hu X, Cao CM, Xiao RP, 2016
- Eplerenone restores 24-h blood pressure circadian rhythm and reduces advanced glycation end-products in rhesus macaques with spontaneous hypertensive metabolic syndrome, Zhang Y, Zheng W, Liu Y, Wang J, Peng Y, Shang H, Hou N, Hu X, Ding Y, Xiao Y, Wang C, Zeng F, Mao J, Zhang J, Ma D, Sun X, Li C, Xiao RP, Zhang X, 2016
- Interaction of β1-adrenoceptor with RAGE mediates cardiomyopathy via CaMKII signaling, Zhu W, Tsang S, Browe, DM, Woo AY, Huang Y, Xu C, Liu JF, Lv F, Zhang Y, Xiao RP, 2016
- Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders, Song RS, Peng W, Zhang Y, Lv F, Wu HK, Guo J, Cao Y, Pi Y, Zhang X, Jin L, Zhang M, Jiang P, Liu F, Meng S, Zhang X, Jiang P, Cao CM, Xiao RP, 2013
- MG53 participates in ischemic postconditioning through the RISK signaling pathway, Cao CM, Zhang Y, Weisleder N, Ferrante C, Wang X, Lv F, Zhang Y, Song R, Hwang M, Jin L, Guo J, Peng W, Li G, Nishi M, Takeshima H, Ma J, Xiao RP, 2011
Awards
- 2023: Lin Songnian Outstanding Young Scholar Award
- 2023: Advanced Individual in Admissions, Peking University 2022-2023
- 2022: 'Eastern Rising Star' Award, 16th Eastern Cardiology Conference
- 2019: Green Leaf Biopharmaceutical Outstanding Young Scholar Award, Peking University
- 2016: Nomination Award, China Heart Congress (CHC) Young Scientist
- 2016: Bayer Investigator Award
- 2013: Supported by the 37th International Congress of Physiological Sciences, Chinese Physiological Society
- 2012: Green Leaf Biopharmaceutical Outstanding Young Scholar Award, Peking University
- 2011: Second Prize, Zhang Xijun Foundation of the Chinese Physiological Society, 11th National Young Excellent Physiology Paper
- 2010: Outstanding Postdoctoral Title, Peking University
- 2010: Richard J Bing Young Scientist Award, Finalist, 20th World Congress of the International Society for Heart Research (ISHR)
