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Fuping You
Basic Medical Sciences
Peking University
Beijing
Language: Chinese, English
Innate Immunity
Cell Death
Pattern Recognition
Viral Resistance
Tumor Genesis
Molecular Mechanisms
Disease Treatment
Antiviral
Immunology
Cell Signaling
Areas of Focus
- Pattern recognition in innate immunity and cell death
- Viral resistance and tumor genesis
- Molecular mechanisms in disease treatment
Work Experience
- 2019-12 to present - Peking University, Institute of Systems Biomedicine, Associate Director, Tenured Researcher
- 2014-12 to 2019-12 - Peking University, Institute of Systems Biomedicine, Researcher, National Overseas Young Talents
- 2013-06 to 2014-12 - Yale University School of Medicine, Associate Research Scientist
- 2011-08 to 2013-06 - Yale University School of Medicine, Postdoctoral Fellow
Academic Background & Achievements
- 2006-09 to 2011-07 PhD: Peking University, School of Life Sciences
- Received National Natural Science Foundation of China's 'Excellent Young Scientist Fund'
- Received Beijing Natural Science Foundation 'Key Research Topic'
Publications
- SAFA facilitates chromatin opening of immune genes through interacting with anti-viral host RNAs, Cao L, Luo Y, Guo X, Liu S, Li S, Li J, Zhang Z, Zhao Y, Zhang Q, Gao F, Ji X, Gao X, Li Y, You F, 2022
- A pyroptosis nanotuner for cancer therapy, Chen B, Yan Y, Yang Y, Cao G, Wang X, Wang Y, Wan F, Yin Q, Wang Z, Li Y, Wang L, Xu B, You F, Zhang Q, Wang Y, 2022
- A gradient pH-sensitive polymer-based antiviral strategy via viroporin-induced membrane acidification, Sun Y, Gong L, Yin Y, Zhang L, Sun Q, Feng K, Cui Y, Zhang Q, Zhang X, Deng X, You F, Lu D, Lin Z, 2022
- TBK1-METTL3 axis facilitates antiviral immunity, Chen J, Wei X, Wang X, Liu T, Zhao Y, Chen L, Luo Y, Du H, Li Y, Liu T, Cao L, Zhou Z, Zhang Z, Liang L, Li L, Yan X, Zhang X, Deng X, Yang G, Yin P, Hao J, Yin Z, You F, 2022
- SARS-CoV-2 spike protein interacts with and activates TLR4, Zhao Y, Kuang M, Li J, Zhu L, Jia Z, Guo X, Hu Y, Kong J, Yin H, Wang X, You F, 2021
- The mitochondrial protein ERAL1 suppresses RNA virus infection by facilitating RIG-I-like receptor signaling, Li S, Kuang M, Chen L, Li Y, Liu S, Du H, Cao L, You F, 2021
- The deubiquitinase OTUD1 enhances iron transport and potentiates host antitumor immunity, Song J, Liu T, Yin Y, Zhao W, Lin Z, Yin Y, Lu D, You F, 2021
- Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19, Guo Q, Zhao Y, Li J, Liu J, Yang X, Guo X, Kuang M, Xia H, Zhang Z, Cao L, Luo Y, Bao L, Wang X, Wei X, Deng W, Wang N, Chen L, Chen J, Zhu H, Gao R, Qin C, Wang X, You F, 2021
- The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers, Cao L, Liu S, Li Y, Yang G, Luo Y, Li S, Du H, Zhao Y, Wang D, Chen J, Zhang Z, Li M, Ouyang S, Gao X, Sun Y, Wang Z, Yang L, Lin R, Wang P, You F, 2019
- HIPK2 is necessary for type I interferon–mediated antiviral immunity, Cao L, Yang G, Gao S, Jing C, Montgomery R, Yin Y, Wang P, Fikrig E, You F, 2019
- ELF4 is critical for induction of type I interferon and the host antiviral response, You F, Wang P, Yang L, Yang G, Zhao Y, Qian F, Walker W, Sutton R, Montgomery R, Lin R, Iwasaki A, Fikrig E, 2013
- Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity, Chen H, Sun H, You F, Sun W, Zhou X, Chen L, Yang J, Wang Y, Tang H, Guan Y, Xia W, Gu J, Ishikawa H, Gutman D, Barber G, Qin Z, Jiang Z, 2011
- PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4, You F, Sun H, Zhou X, Sun W, Liang S, Zhai Z, Jiang Z, 2009
Awards
- 2015: Green Leaf Outstanding Life Science Fund
