Professor | Fuping You | Asia Growth Partners

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Name	Fuping You
Contact Information	fupingyou@bjmu.edu.cn
Language ability	Chinese, English
Province	Beijing

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Name

Fuping You

Contact Information

fupingyou@bjmu.edu.cn

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	Peking University
Faculty	Basic Medical Sciences
Academic Background & Achievements	2006-09 to 2011-07 PhD: Peking University, School of Life Sciences Received National Natural Science Foundation of China's 'Excellent Young Scientist Fund' Received Beijing Natural Science Foundation 'Key Research Topic'
Work Experience	2019-12 to present - Peking University, Institute of Systems Biomedicine, Associate Director, Tenured Researcher 2014-12 to 2019-12 - Peking University, Institute of Systems Biomedicine, Researcher, National Overseas Young Talents 2013-06 to 2014-12 - Yale University School of Medicine, Associate Research Scientist 2011-08 to 2013-06 - Yale University School of Medicine, Postdoctoral Fellow
Awards	2015: Green Leaf Outstanding Life Science Fund

University/Lab Affiliation and Title

Peking University

Faculty

Basic Medical Sciences

Academic Background & Achievements

2006-09 to 2011-07 PhD: Peking University, School of Life Sciences
Received National Natural Science Foundation of China's 'Excellent Young Scientist Fund'
Received Beijing Natural Science Foundation 'Key Research Topic'

Work Experience

2019-12 to present - Peking University, Institute of Systems Biomedicine, Associate Director, Tenured Researcher
2014-12 to 2019-12 - Peking University, Institute of Systems Biomedicine, Researcher, National Overseas Young Talents
2013-06 to 2014-12 - Yale University School of Medicine, Associate Research Scientist
2011-08 to 2013-06 - Yale University School of Medicine, Postdoctoral Fellow

Awards

2015: Green Leaf Outstanding Life Science Fund

Areas of Focus	Pattern recognition in innate immunity and cell death Viral resistance and tumor genesis Molecular mechanisms in disease treatment
Publications	SAFA facilitates chromatin opening of immune genes through interacting with anti-viral host RNAs, Cao L, Luo Y, Guo X, Liu S, Li S, Li J, Zhang Z, Zhao Y, Zhang Q, Gao F, Ji X, Gao X, Li Y, You F, 2022 A pyroptosis nanotuner for cancer therapy, Chen B, Yan Y, Yang Y, Cao G, Wang X, Wang Y, Wan F, Yin Q, Wang Z, Li Y, Wang L, Xu B, You F, Zhang Q, Wang Y, 2022 A gradient pH-sensitive polymer-based antiviral strategy via viroporin-induced membrane acidification, Sun Y, Gong L, Yin Y, Zhang L, Sun Q, Feng K, Cui Y, Zhang Q, Zhang X, Deng X, You F, Lu D, Lin Z, 2022 TBK1-METTL3 axis facilitates antiviral immunity, Chen J, Wei X, Wang X, Liu T, Zhao Y, Chen L, Luo Y, Du H, Li Y, Liu T, Cao L, Zhou Z, Zhang Z, Liang L, Li L, Yan X, Zhang X, Deng X, Yang G, Yin P, Hao J, Yin Z, You F, 2022 SARS-CoV-2 spike protein interacts with and activates TLR4, Zhao Y, Kuang M, Li J, Zhu L, Jia Z, Guo X, Hu Y, Kong J, Yin H, Wang X, You F, 2021 The mitochondrial protein ERAL1 suppresses RNA virus infection by facilitating RIG-I-like receptor signaling, Li S, Kuang M, Chen L, Li Y, Liu S, Du H, Cao L, You F, 2021 The deubiquitinase OTUD1 enhances iron transport and potentiates host antitumor immunity, Song J, Liu T, Yin Y, Zhao W, Lin Z, Yin Y, Lu D, You F, 2021 Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19, Guo Q, Zhao Y, Li J, Liu J, Yang X, Guo X, Kuang M, Xia H, Zhang Z, Cao L, Luo Y, Bao L, Wang X, Wei X, Deng W, Wang N, Chen L, Chen J, Zhu H, Gao R, Qin C, Wang X, You F, 2021 The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers, Cao L, Liu S, Li Y, Yang G, Luo Y, Li S, Du H, Zhao Y, Wang D, Chen J, Zhang Z, Li M, Ouyang S, Gao X, Sun Y, Wang Z, Yang L, Lin R, Wang P, You F, 2019 HIPK2 is necessary for type I interferon–mediated antiviral immunity, Cao L, Yang G, Gao S, Jing C, Montgomery R, Yin Y, Wang P, Fikrig E, You F, 2019 ELF4 is critical for induction of type I interferon and the host antiviral response, You F, Wang P, Yang L, Yang G, Zhao Y, Qian F, Walker W, Sutton R, Montgomery R, Lin R, Iwasaki A, Fikrig E, 2013 Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity, Chen H, Sun H, You F, Sun W, Zhou X, Chen L, Yang J, Wang Y, Tang H, Guan Y, Xia W, Gu J, Ishikawa H, Gutman D, Barber G, Qin Z, Jiang Z, 2011 PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4, You F, Sun H, Zhou X, Sun W, Liang S, Zhai Z, Jiang Z, 2009

Areas of Focus

Pattern recognition in innate immunity and cell death
Viral resistance and tumor genesis
Molecular mechanisms in disease treatment

Publications

SAFA facilitates chromatin opening of immune genes through interacting with anti-viral host RNAs, Cao L, Luo Y, Guo X, Liu S, Li S, Li J, Zhang Z, Zhao Y, Zhang Q, Gao F, Ji X, Gao X, Li Y, You F, 2022
A pyroptosis nanotuner for cancer therapy, Chen B, Yan Y, Yang Y, Cao G, Wang X, Wang Y, Wan F, Yin Q, Wang Z, Li Y, Wang L, Xu B, You F, Zhang Q, Wang Y, 2022
A gradient pH-sensitive polymer-based antiviral strategy via viroporin-induced membrane acidification, Sun Y, Gong L, Yin Y, Zhang L, Sun Q, Feng K, Cui Y, Zhang Q, Zhang X, Deng X, You F, Lu D, Lin Z, 2022
TBK1-METTL3 axis facilitates antiviral immunity, Chen J, Wei X, Wang X, Liu T, Zhao Y, Chen L, Luo Y, Du H, Li Y, Liu T, Cao L, Zhou Z, Zhang Z, Liang L, Li L, Yan X, Zhang X, Deng X, Yang G, Yin P, Hao J, Yin Z, You F, 2022
SARS-CoV-2 spike protein interacts with and activates TLR4, Zhao Y, Kuang M, Li J, Zhu L, Jia Z, Guo X, Hu Y, Kong J, Yin H, Wang X, You F, 2021
The mitochondrial protein ERAL1 suppresses RNA virus infection by facilitating RIG-I-like receptor signaling, Li S, Kuang M, Chen L, Li Y, Liu S, Du H, Cao L, You F, 2021
The deubiquitinase OTUD1 enhances iron transport and potentiates host antitumor immunity, Song J, Liu T, Yin Y, Zhao W, Lin Z, Yin Y, Lu D, You F, 2021
Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19, Guo Q, Zhao Y, Li J, Liu J, Yang X, Guo X, Kuang M, Xia H, Zhang Z, Cao L, Luo Y, Bao L, Wang X, Wei X, Deng W, Wang N, Chen L, Chen J, Zhu H, Gao R, Qin C, Wang X, You F, 2021
The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers, Cao L, Liu S, Li Y, Yang G, Luo Y, Li S, Du H, Zhao Y, Wang D, Chen J, Zhang Z, Li M, Ouyang S, Gao X, Sun Y, Wang Z, Yang L, Lin R, Wang P, You F, 2019
HIPK2 is necessary for type I interferon–mediated antiviral immunity, Cao L, Yang G, Gao S, Jing C, Montgomery R, Yin Y, Wang P, Fikrig E, You F, 2019
ELF4 is critical for induction of type I interferon and the host antiviral response, You F, Wang P, Yang L, Yang G, Zhao Y, Qian F, Walker W, Sutton R, Montgomery R, Lin R, Iwasaki A, Fikrig E, 2013
Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity, Chen H, Sun H, You F, Sun W, Zhou X, Chen L, Yang J, Wang Y, Tang H, Guan Y, Xia W, Gu J, Ishikawa H, Gutman D, Barber G, Qin Z, Jiang Z, 2011
PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4, You F, Sun H, Zhou X, Sun W, Liang S, Zhai Z, Jiang Z, 2009

Innate Immunity Cell Death Pattern Recognition Viral Resistance Tumor Genesis Molecular Mechanisms Disease Treatment Antiviral Immunology Cell Signaling

Dan Lu - Peking University

Ying Wu - Wuhan University

Cong Zeng - Fudan University

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