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Lin He
Basic Medical Sciences
Peking University
Beijing
Language: Chinese, English
Epigenetics
Cancer
Gene Transcription
Disease Progression
Traditional Chinese Medicine
Anti-Tumor
Molecular Mechanisms
Intervention Strategies
Clinical Diseases
Integrated Medicine
Areas of Focus
- Epigenetic regulation and intervention strategies in cancer
- Mechanisms of epigenetic and gene transcription regulation in disease progression
- Molecular mechanisms of traditional Chinese medicine in anti-tumor effects
- Intervention strategies for clinically relevant diseases using integrated traditional Chinese and Western medicine
Work Experience
- 2022.10 to present - Peking University - Assistant Professor, Associate Researcher, Doctoral Supervisor
- 2018.10—2022.09 - Peking University - Postdoctoral Researcher
- 2013.09—2018.09 - Peking University - PhD Student
Academic Background & Achievements
- 2018.10—2022.09 Postdoctoral Researcher: Peking University, Pharmacy
- 2013.09—2018.09 PhD: Peking University, Medical Biochemistry and Molecular Biology
- 2009.09—2013.08 Bachelor: Minzu University of China, Biological Sciences
- Undertook 6 major projects including National Natural Science Foundation of China
Publications
- Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer’s disease, Rui-Yuan Pan, Lin He, Jing Zhang, Xinhua Liu, Yajin Liao, Yuhan Yan, Ju Gao, Qianqian Li, Yang Liao, Jinbo Cheng, Qu Xing, Fangxia Guan, Xinglong Wang, Jie Zhang, Luyang Sun, and Zengqiang Yuan, 2022
- Imbalance of the reciprocally inhibitory loop between the ubiquitin-specific protease USP43 and EGFR/PI3K/AKT drives breast carcinogenesis, Lin He, Xinhua Liu, Jianguo Yang, Wanjin Li, Shumeng Liu, Xujun Liu, Ziran Yang, Jie Ren, Yue Wang, Lin Shan, Fei Pei, Liandi Lei, Yu Zhang, Xia Yi, Xiaohan Yang, Jing Liang, Luyang Sun, and Yongfeng Shang, 2018
- SCFJFK Is Functionally Linked to Obesity and Metabolic Syndrome, Lin He, Ruorong Yan, Ziran Yang, Yue Zhang, Xinhua Liu, Jianguo Yang, Xujun Liu, Xiaoping Liu, Lu Xia, Yue Wang, Jiajing Wu, Xiaodi Wu, Lin Shan, Xiaohan Yang, Jing Liang, Yongfeng Shang, and Luyang Sun, 2021
- JFK Is a Hypoxia-inducible Gene that Functions to Promote Breast Carcinogenesis, Ziran Yang, Xuehong Zhou, Enrun Zheng, Yizhou Wang, Xinhua Liu, Yue Wang Yanpu Wang, Zhaofei Liu, Fei Pei, Yue Zhang, Jie Ren, Yunchao Huang, Lu Xia, Sudun Guan, Sen Qin, Feiya Suo, Jie Shi, Lijing Wang, Lin He, and Luyang Sun, 2021
- The existence of a nonclassical TCA cycle in the nucleus that wires the metabolic-epigenetic circuitry, Xujun Liu, Wenzhe Si, Lin He, Jianguo Yang, Yani Peng, Jie Ren, Xiaoping Liu, Tong Jin, Huajing Yu, Zihan Zhang, Xiao Chen, Wenting Zhang, Lu Xia, Yunchao Huang, Yue Wang, Shumeng Liu, Lin Shan, Yu Zhang, Xiaohan Yang, Haixia Li, Jing Liang, Luyang Sun, and Yongfeng Shang, 2021
- UHRF2 commissions the completion of DNA demethylation through allosteric activation by 5hmC and K33-linked ubiquitination of XRCC1, Xiaoping Liu, Bosen Xu, Jianguo Yang, Lin He, Zihan Zhang, Xiao Cheng, Huajing Yu, Xujun Liu, Tong Jin, Yani Peng, Yunchao Huang, Lu Xia, Yue Wang, Jiajing Wu, Xiaodi Wu, Shumeng Liu, Lin Shan, Xiaohan Yang, Luyang Sun, Jing Liang, Yu Zhang, and Yongfeng Shang, 2021
- TRPS1 drives heterochromatic origin refiring and cancer genome evolution, Jianguo Yang, Xiaoping Liu, Yunchao Huang, Lin He, Wenting Zhang, Jie Ren, Yue Wang, Jiajing Wu, Xiaodi Wu, Lin Shan, Xiaohan Yang, Luyang Sun, Jing Liang, Yu Zhang, and Yongfeng Shang, 2021
- ZNF774 is a potent suppressor of hepatocarcinogenesis through dampening the NOTCH2 signaling, Chengjian Guan, Lin He, Zhenyu Chang, Xinjin Gu, Jing Liang, and Rong Liu, 2020
- Global crotonylome reveals CDYL-regulated RPA1 crotonylation in homologous recombination–mediated DNA repair, Huajing Yu, Chen Bu, Yuncheng Liu, Tianyu Gong, Xiaoping Liu, Shumeng Liu, Xiaojun Peng, Wenting Zhang, Yani Peng, Jianguo Yang, Lin He, Yu Zhang, Xia Yi, Xiaohan Yang, Luyang Sun, Yongfeng Shang, Zhongyi Cheng, and Jing Liang, 2020
- USP11 acts as a histone deubiquitinase functioning in chromatin reorganization during DNA repair, Xia Ting, Lu Xia, Jianguo Yang, Lin He, Wenzhe Si, Yongfeng Shang, and Luyang Sun, 2019
- Identification of a 35S U4/U6.U5 tri-small nuclear ribonucleoprotein (tri-snRNP) complex intermediate in spliceosome assembly, Zhe Chen, Zhe Chen, Bin Gui, Yu Zhang, Guojia Xie, Wanjin Li, Shumeng Liu, Bosen Xu, Chongyang Wu, Lin He, Jianguo Yang, Xia Yi, Xiaohan Yang, Luyang Sun, Jing Liang, and Yongfeng Shang, 2017
- ZNF516 suppresses EGFR by targeting the CtBP/LSD1/CoREST complex to chromatin, Lifang Li, Xinhua Liu, Lin He, Jianguo Yang, Fei Pei, Wanjin Li, Shumeng Liu, Zhe Chen, Guojia Xie, Bosen Xu, Xia Ting, Zihan Zhang, Tong Jin, Xujun Liu, Wenting Zhang, Shuai Yuan, Ziran Yang, Chongyang Wu, Yu Zhang, Xiaohan Yang, Xia Yi, Jing Liang, Yongfeng Shang, and Luyang Sun, 2017
- Chromodomain Protein CDYL Acts as a Crotonyl-CoA Hydratase to Regulate Histone Crotonylation and Spermatogenesis, Shumeng Liu, Huajing Yu, Yongqing Liu, Xinhua Liu, Yu Zhang, Chen Bu, Shuai Yuan, Zhe Chen, Guojia Xie, Wanjin Li, Bosen Xu, Jianguo Yang, Lin He, Tong Jin, Yundong Xiong, Luyang Sun, Xiaohui Liu, Chunsheng Han, Zhongyi Cheng, Jing Liang, and Yongfeng Shang, 2017
- The FOXN3-NEAT1-SIN3A repressor complex promotes progression of hormonally responsive breast cancer, Wanjin Li, Zihan Zhang, Xinhua Liu, Xiao Cheng, Yu Zhang, Xiao Han, Shumeng Liu, Jianguo Yang, Bosen Xu, Lin He, Luyang Sun, Jing Liang, and Yongfeng Shang, 2017
- SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability, Lei Li, Lan Shi, Shangda Yang, Ruorong Yan, Di Zhang, Jianguo Yang, Lin He, Wanjin Li, Xia Yi, Luyang Sun, Jing Liang, Zhe Chen, Lei Shi, Yongfeng Shang, and Wenhua Yu, 2016
- Nucleation of DNA repair factors by FOXA1 links DNA demethylation to transcriptional pioneering, Yu Zhang, Di Zhang, Qian Li, Jing Liang, Luyang Sun, Xia Yi, Zhe Chen, Ruorong Yan, Guojia Xie, Wanjin Li, Shumeng Liu, Bosen Xu, Lei Li, Jianguo Yang, Lin He, and Yongfeng Shang, 2016
- Dysfunction of the Reciprocal Feedback Loop between GATA3- and ZEB2-Nucleated Repression Programs Contributes to Breast Cancer Metastasis, Wenzhe Si, Wei Huang, Yu Zheng, Yang Yang, Xujun Liu, Lin Shan, Xing Zhou, Yue Wang, Dongxue Su, Jie Gao, Ruorong Yan, Xiao Han, Wanjin Li, Lin He, Lei Shi, Chenghao Xuan, Jing Liang, Luyang Sun, Yan Wang, and Yongfeng Shang, 2015
- SCF(JFK) is a bona fide E3 ligase for ING4 and a potent promoter of the angiogenesis and metastasis of breast cancer, Ruorong Yan, Lin He, Zhongwu Li, Xiao Han, Jing Liang, Wenzhe Si, Zhe Chen, Lei Li, Guojia Xie, Wanjin Li
Awards
- 2022: Peking University Basic Medical College Young Talent
- 2021: Peking University 'Bayer' Postdoctoral
- 2021: Peking University Medical Department Outstanding Postdoctoral
- 2019: Peking University Outstanding PhD Thesis
- 2018: Peking University Boya Postdoctoral
- 2018: Peking University Outstanding Graduate and Meritorious Student
- 2017: Peking University Medical Graduate Special (Diligent and Virtuous Medical Student) Scholarship
- 2014: National Scholarship
