Professor | Lin He | Asia Growth Partners

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Name	Lin He
Contact Information	linhe@bjmu.edu.cn
Language ability	Chinese, English
Province	Beijing

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Name

Lin He

Contact Information

linhe@bjmu.edu.cn

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	Peking University
Faculty	Basic Medical Sciences
Academic Background & Achievements	2018.10—2022.09 Postdoctoral Researcher: Peking University, Pharmacy 2013.09—2018.09 PhD: Peking University, Medical Biochemistry and Molecular Biology 2009.09—2013.08 Bachelor: Minzu University of China, Biological Sciences Undertook 6 major projects including National Natural Science Foundation of China
Work Experience	2022.10 to present - Peking University - Assistant Professor, Associate Researcher, Doctoral Supervisor 2018.10—2022.09 - Peking University - Postdoctoral Researcher 2013.09—2018.09 - Peking University - PhD Student
Awards	2022: Peking University Basic Medical College Young Talent 2021: Peking University 'Bayer' Postdoctoral 2021: Peking University Medical Department Outstanding Postdoctoral 2019: Peking University Outstanding PhD Thesis 2018: Peking University Boya Postdoctoral 2018: Peking University Outstanding Graduate and Meritorious Student 2017: Peking University Medical Graduate Special (Diligent and Virtuous Medical Student) Scholarship 2014: National Scholarship

University/Lab Affiliation and Title

Peking University

Faculty

Basic Medical Sciences

Academic Background & Achievements

2018.10—2022.09 Postdoctoral Researcher: Peking University, Pharmacy
2013.09—2018.09 PhD: Peking University, Medical Biochemistry and Molecular Biology
2009.09—2013.08 Bachelor: Minzu University of China, Biological Sciences
Undertook 6 major projects including National Natural Science Foundation of China

Work Experience

2022.10 to present - Peking University - Assistant Professor, Associate Researcher, Doctoral Supervisor
2018.10—2022.09 - Peking University - Postdoctoral Researcher
2013.09—2018.09 - Peking University - PhD Student

Awards

2022: Peking University Basic Medical College Young Talent
2021: Peking University 'Bayer' Postdoctoral
2021: Peking University Medical Department Outstanding Postdoctoral
2019: Peking University Outstanding PhD Thesis
2018: Peking University Boya Postdoctoral
2018: Peking University Outstanding Graduate and Meritorious Student
2017: Peking University Medical Graduate Special (Diligent and Virtuous Medical Student) Scholarship
2014: National Scholarship

Areas of Focus	Epigenetic regulation and intervention strategies in cancer Mechanisms of epigenetic and gene transcription regulation in disease progression Molecular mechanisms of traditional Chinese medicine in anti-tumor effects Intervention strategies for clinically relevant diseases using integrated traditional Chinese and Western medicine
Publications	Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer’s disease, Rui-Yuan Pan, Lin He, Jing Zhang, Xinhua Liu, Yajin Liao, Yuhan Yan, Ju Gao, Qianqian Li, Yang Liao, Jinbo Cheng, Qu Xing, Fangxia Guan, Xinglong Wang, Jie Zhang, Luyang Sun, and Zengqiang Yuan, 2022 Imbalance of the reciprocally inhibitory loop between the ubiquitin-specific protease USP43 and EGFR/PI3K/AKT drives breast carcinogenesis, Lin He, Xinhua Liu, Jianguo Yang, Wanjin Li, Shumeng Liu, Xujun Liu, Ziran Yang, Jie Ren, Yue Wang, Lin Shan, Fei Pei, Liandi Lei, Yu Zhang, Xia Yi, Xiaohan Yang, Jing Liang, Luyang Sun, and Yongfeng Shang, 2018 SCFJFK Is Functionally Linked to Obesity and Metabolic Syndrome, Lin He, Ruorong Yan, Ziran Yang, Yue Zhang, Xinhua Liu, Jianguo Yang, Xujun Liu, Xiaoping Liu, Lu Xia, Yue Wang, Jiajing Wu, Xiaodi Wu, Lin Shan, Xiaohan Yang, Jing Liang, Yongfeng Shang, and Luyang Sun, 2021 JFK Is a Hypoxia-inducible Gene that Functions to Promote Breast Carcinogenesis, Ziran Yang, Xuehong Zhou, Enrun Zheng, Yizhou Wang, Xinhua Liu, Yue Wang Yanpu Wang, Zhaofei Liu, Fei Pei, Yue Zhang, Jie Ren, Yunchao Huang, Lu Xia, Sudun Guan, Sen Qin, Feiya Suo, Jie Shi, Lijing Wang, Lin He, and Luyang Sun, 2021 The existence of a nonclassical TCA cycle in the nucleus that wires the metabolic-epigenetic circuitry, Xujun Liu, Wenzhe Si, Lin He, Jianguo Yang, Yani Peng, Jie Ren, Xiaoping Liu, Tong Jin, Huajing Yu, Zihan Zhang, Xiao Chen, Wenting Zhang, Lu Xia, Yunchao Huang, Yue Wang, Shumeng Liu, Lin Shan, Yu Zhang, Xiaohan Yang, Haixia Li, Jing Liang, Luyang Sun, and Yongfeng Shang, 2021 UHRF2 commissions the completion of DNA demethylation through allosteric activation by 5hmC and K33-linked ubiquitination of XRCC1, Xiaoping Liu, Bosen Xu, Jianguo Yang, Lin He, Zihan Zhang, Xiao Cheng, Huajing Yu, Xujun Liu, Tong Jin, Yani Peng, Yunchao Huang, Lu Xia, Yue Wang, Jiajing Wu, Xiaodi Wu, Shumeng Liu, Lin Shan, Xiaohan Yang, Luyang Sun, Jing Liang, Yu Zhang, and Yongfeng Shang, 2021 TRPS1 drives heterochromatic origin refiring and cancer genome evolution, Jianguo Yang, Xiaoping Liu, Yunchao Huang, Lin He, Wenting Zhang, Jie Ren, Yue Wang, Jiajing Wu, Xiaodi Wu, Lin Shan, Xiaohan Yang, Luyang Sun, Jing Liang, Yu Zhang, and Yongfeng Shang, 2021 ZNF774 is a potent suppressor of hepatocarcinogenesis through dampening the NOTCH2 signaling, Chengjian Guan, Lin He, Zhenyu Chang, Xinjin Gu, Jing Liang, and Rong Liu, 2020 Global crotonylome reveals CDYL-regulated RPA1 crotonylation in homologous recombination–mediated DNA repair, Huajing Yu, Chen Bu, Yuncheng Liu, Tianyu Gong, Xiaoping Liu, Shumeng Liu, Xiaojun Peng, Wenting Zhang, Yani Peng, Jianguo Yang, Lin He, Yu Zhang, Xia Yi, Xiaohan Yang, Luyang Sun, Yongfeng Shang, Zhongyi Cheng, and Jing Liang, 2020 USP11 acts as a histone deubiquitinase functioning in chromatin reorganization during DNA repair, Xia Ting, Lu Xia, Jianguo Yang, Lin He, Wenzhe Si, Yongfeng Shang, and Luyang Sun, 2019 Identification of a 35S U4/U6.U5 tri-small nuclear ribonucleoprotein (tri-snRNP) complex intermediate in spliceosome assembly, Zhe Chen, Zhe Chen, Bin Gui, Yu Zhang, Guojia Xie, Wanjin Li, Shumeng Liu, Bosen Xu, Chongyang Wu, Lin He, Jianguo Yang, Xia Yi, Xiaohan Yang, Luyang Sun, Jing Liang, and Yongfeng Shang, 2017 ZNF516 suppresses EGFR by targeting the CtBP/LSD1/CoREST complex to chromatin, Lifang Li, Xinhua Liu, Lin He, Jianguo Yang, Fei Pei, Wanjin Li, Shumeng Liu, Zhe Chen, Guojia Xie, Bosen Xu, Xia Ting, Zihan Zhang, Tong Jin, Xujun Liu, Wenting Zhang, Shuai Yuan, Ziran Yang, Chongyang Wu, Yu Zhang, Xiaohan Yang, Xia Yi, Jing Liang, Yongfeng Shang, and Luyang Sun, 2017 Chromodomain Protein CDYL Acts as a Crotonyl-CoA Hydratase to Regulate Histone Crotonylation and Spermatogenesis, Shumeng Liu, Huajing Yu, Yongqing Liu, Xinhua Liu, Yu Zhang, Chen Bu, Shuai Yuan, Zhe Chen, Guojia Xie, Wanjin Li, Bosen Xu, Jianguo Yang, Lin He, Tong Jin, Yundong Xiong, Luyang Sun, Xiaohui Liu, Chunsheng Han, Zhongyi Cheng, Jing Liang, and Yongfeng Shang, 2017 The FOXN3-NEAT1-SIN3A repressor complex promotes progression of hormonally responsive breast cancer, Wanjin Li, Zihan Zhang, Xinhua Liu, Xiao Cheng, Yu Zhang, Xiao Han, Shumeng Liu, Jianguo Yang, Bosen Xu, Lin He, Luyang Sun, Jing Liang, and Yongfeng Shang, 2017 SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability, Lei Li, Lan Shi, Shangda Yang, Ruorong Yan, Di Zhang, Jianguo Yang, Lin He, Wanjin Li, Xia Yi, Luyang Sun, Jing Liang, Zhe Chen, Lei Shi, Yongfeng Shang, and Wenhua Yu, 2016 Nucleation of DNA repair factors by FOXA1 links DNA demethylation to transcriptional pioneering, Yu Zhang, Di Zhang, Qian Li, Jing Liang, Luyang Sun, Xia Yi, Zhe Chen, Ruorong Yan, Guojia Xie, Wanjin Li, Shumeng Liu, Bosen Xu, Lei Li, Jianguo Yang, Lin He, and Yongfeng Shang, 2016 Dysfunction of the Reciprocal Feedback Loop between GATA3- and ZEB2-Nucleated Repression Programs Contributes to Breast Cancer Metastasis, Wenzhe Si, Wei Huang, Yu Zheng, Yang Yang, Xujun Liu, Lin Shan, Xing Zhou, Yue Wang, Dongxue Su, Jie Gao, Ruorong Yan, Xiao Han, Wanjin Li, Lin He, Lei Shi, Chenghao Xuan, Jing Liang, Luyang Sun, Yan Wang, and Yongfeng Shang, 2015 SCF(JFK) is a bona fide E3 ligase for ING4 and a potent promoter of the angiogenesis and metastasis of breast cancer, Ruorong Yan, Lin He, Zhongwu Li, Xiao Han, Jing Liang, Wenzhe Si, Zhe Chen, Lei Li, Guojia Xie, Wanjin Li

Areas of Focus

Epigenetic regulation and intervention strategies in cancer
Mechanisms of epigenetic and gene transcription regulation in disease progression
Molecular mechanisms of traditional Chinese medicine in anti-tumor effects
Intervention strategies for clinically relevant diseases using integrated traditional Chinese and Western medicine

Publications

Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer’s disease, Rui-Yuan Pan, Lin He, Jing Zhang, Xinhua Liu, Yajin Liao, Yuhan Yan, Ju Gao, Qianqian Li, Yang Liao, Jinbo Cheng, Qu Xing, Fangxia Guan, Xinglong Wang, Jie Zhang, Luyang Sun, and Zengqiang Yuan, 2022
Imbalance of the reciprocally inhibitory loop between the ubiquitin-specific protease USP43 and EGFR/PI3K/AKT drives breast carcinogenesis, Lin He, Xinhua Liu, Jianguo Yang, Wanjin Li, Shumeng Liu, Xujun Liu, Ziran Yang, Jie Ren, Yue Wang, Lin Shan, Fei Pei, Liandi Lei, Yu Zhang, Xia Yi, Xiaohan Yang, Jing Liang, Luyang Sun, and Yongfeng Shang, 2018
SCFJFK Is Functionally Linked to Obesity and Metabolic Syndrome, Lin He, Ruorong Yan, Ziran Yang, Yue Zhang, Xinhua Liu, Jianguo Yang, Xujun Liu, Xiaoping Liu, Lu Xia, Yue Wang, Jiajing Wu, Xiaodi Wu, Lin Shan, Xiaohan Yang, Jing Liang, Yongfeng Shang, and Luyang Sun, 2021
JFK Is a Hypoxia-inducible Gene that Functions to Promote Breast Carcinogenesis, Ziran Yang, Xuehong Zhou, Enrun Zheng, Yizhou Wang, Xinhua Liu, Yue Wang Yanpu Wang, Zhaofei Liu, Fei Pei, Yue Zhang, Jie Ren, Yunchao Huang, Lu Xia, Sudun Guan, Sen Qin, Feiya Suo, Jie Shi, Lijing Wang, Lin He, and Luyang Sun, 2021
The existence of a nonclassical TCA cycle in the nucleus that wires the metabolic-epigenetic circuitry, Xujun Liu, Wenzhe Si, Lin He, Jianguo Yang, Yani Peng, Jie Ren, Xiaoping Liu, Tong Jin, Huajing Yu, Zihan Zhang, Xiao Chen, Wenting Zhang, Lu Xia, Yunchao Huang, Yue Wang, Shumeng Liu, Lin Shan, Yu Zhang, Xiaohan Yang, Haixia Li, Jing Liang, Luyang Sun, and Yongfeng Shang, 2021
UHRF2 commissions the completion of DNA demethylation through allosteric activation by 5hmC and K33-linked ubiquitination of XRCC1, Xiaoping Liu, Bosen Xu, Jianguo Yang, Lin He, Zihan Zhang, Xiao Cheng, Huajing Yu, Xujun Liu, Tong Jin, Yani Peng, Yunchao Huang, Lu Xia, Yue Wang, Jiajing Wu, Xiaodi Wu, Shumeng Liu, Lin Shan, Xiaohan Yang, Luyang Sun, Jing Liang, Yu Zhang, and Yongfeng Shang, 2021
TRPS1 drives heterochromatic origin refiring and cancer genome evolution, Jianguo Yang, Xiaoping Liu, Yunchao Huang, Lin He, Wenting Zhang, Jie Ren, Yue Wang, Jiajing Wu, Xiaodi Wu, Lin Shan, Xiaohan Yang, Luyang Sun, Jing Liang, Yu Zhang, and Yongfeng Shang, 2021
ZNF774 is a potent suppressor of hepatocarcinogenesis through dampening the NOTCH2 signaling, Chengjian Guan, Lin He, Zhenyu Chang, Xinjin Gu, Jing Liang, and Rong Liu, 2020
Global crotonylome reveals CDYL-regulated RPA1 crotonylation in homologous recombination–mediated DNA repair, Huajing Yu, Chen Bu, Yuncheng Liu, Tianyu Gong, Xiaoping Liu, Shumeng Liu, Xiaojun Peng, Wenting Zhang, Yani Peng, Jianguo Yang, Lin He, Yu Zhang, Xia Yi, Xiaohan Yang, Luyang Sun, Yongfeng Shang, Zhongyi Cheng, and Jing Liang, 2020
USP11 acts as a histone deubiquitinase functioning in chromatin reorganization during DNA repair, Xia Ting, Lu Xia, Jianguo Yang, Lin He, Wenzhe Si, Yongfeng Shang, and Luyang Sun, 2019
Identification of a 35S U4/U6.U5 tri-small nuclear ribonucleoprotein (tri-snRNP) complex intermediate in spliceosome assembly, Zhe Chen, Zhe Chen, Bin Gui, Yu Zhang, Guojia Xie, Wanjin Li, Shumeng Liu, Bosen Xu, Chongyang Wu, Lin He, Jianguo Yang, Xia Yi, Xiaohan Yang, Luyang Sun, Jing Liang, and Yongfeng Shang, 2017
ZNF516 suppresses EGFR by targeting the CtBP/LSD1/CoREST complex to chromatin, Lifang Li, Xinhua Liu, Lin He, Jianguo Yang, Fei Pei, Wanjin Li, Shumeng Liu, Zhe Chen, Guojia Xie, Bosen Xu, Xia Ting, Zihan Zhang, Tong Jin, Xujun Liu, Wenting Zhang, Shuai Yuan, Ziran Yang, Chongyang Wu, Yu Zhang, Xiaohan Yang, Xia Yi, Jing Liang, Yongfeng Shang, and Luyang Sun, 2017
Chromodomain Protein CDYL Acts as a Crotonyl-CoA Hydratase to Regulate Histone Crotonylation and Spermatogenesis, Shumeng Liu, Huajing Yu, Yongqing Liu, Xinhua Liu, Yu Zhang, Chen Bu, Shuai Yuan, Zhe Chen, Guojia Xie, Wanjin Li, Bosen Xu, Jianguo Yang, Lin He, Tong Jin, Yundong Xiong, Luyang Sun, Xiaohui Liu, Chunsheng Han, Zhongyi Cheng, Jing Liang, and Yongfeng Shang, 2017
The FOXN3-NEAT1-SIN3A repressor complex promotes progression of hormonally responsive breast cancer, Wanjin Li, Zihan Zhang, Xinhua Liu, Xiao Cheng, Yu Zhang, Xiao Han, Shumeng Liu, Jianguo Yang, Bosen Xu, Lin He, Luyang Sun, Jing Liang, and Yongfeng Shang, 2017
SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability, Lei Li, Lan Shi, Shangda Yang, Ruorong Yan, Di Zhang, Jianguo Yang, Lin He, Wanjin Li, Xia Yi, Luyang Sun, Jing Liang, Zhe Chen, Lei Shi, Yongfeng Shang, and Wenhua Yu, 2016
Nucleation of DNA repair factors by FOXA1 links DNA demethylation to transcriptional pioneering, Yu Zhang, Di Zhang, Qian Li, Jing Liang, Luyang Sun, Xia Yi, Zhe Chen, Ruorong Yan, Guojia Xie, Wanjin Li, Shumeng Liu, Bosen Xu, Lei Li, Jianguo Yang, Lin He, and Yongfeng Shang, 2016
Dysfunction of the Reciprocal Feedback Loop between GATA3- and ZEB2-Nucleated Repression Programs Contributes to Breast Cancer Metastasis, Wenzhe Si, Wei Huang, Yu Zheng, Yang Yang, Xujun Liu, Lin Shan, Xing Zhou, Yue Wang, Dongxue Su, Jie Gao, Ruorong Yan, Xiao Han, Wanjin Li, Lin He, Lei Shi, Chenghao Xuan, Jing Liang, Luyang Sun, Yan Wang, and Yongfeng Shang, 2015
SCF(JFK) is a bona fide E3 ligase for ING4 and a potent promoter of the angiogenesis and metastasis of breast cancer, Ruorong Yan, Lin He, Zhongwu Li, Xiao Han, Jing Liang, Wenzhe Si, Zhe Chen, Lei Li, Guojia Xie, Wanjin Li

Epigenetics Cancer Gene Transcription Disease Progression Traditional Chinese Medicine Anti-Tumor Molecular Mechanisms Intervention Strategies Clinical Diseases Integrated Medicine

Li Jing - Chongqing Medical University

Dilong Chen - Chongqing Medical University

Xiaonan Wang - China Medical University

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