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Xiao Rui
Immunology and Metabolion
Wuhan University
Hubei
Language: Chinese, English
Genomics
Rnaomics
Rna-Binding
Proteins
Mechanisms
Functions
Gene Transcription
Chromatin Interaction
Disease Causation
Molecular Pathology
Areas of Focus
- Functional genomics and RNAomics
- Mechanisms and functions of RNA-binding proteins
Work Experience
- 2011-2017 - University of California, San Diego, School of Medicine, Department of Cellular and Molecular Medicine, Postdoctoral Researcher; Supervisor: Professor Fu Xiangdong
- 2017-present - Wuhan University, Medical Research Institute, Professor
- 2020-present - Wuhan University, Center for Immunology and Metabolism, Principal Investigator
- 2022-present - Wuhan University, Taikang Center for Life Sciences, Principal Investigator
Academic Background & Achievements
- 1999-2003 Bachelor: Wuhan University, School of Life Sciences
- 2004-2010 PhD: Wuhan University, School of Life Sciences; Supervisor: Professor Fu Xiangdong
Publications
- RBM22 Regulates RNA Polymerase II 5' Pausing, Elongation Rate and Termination by Coordinating 7SK-P-TEFb complex and SPT5, Du, X., Qin W., Yang, C., Dai, L., San, M., Xia, Y., Zhou, S., Wang, M., Wu, S., Zhang, S., Zhou, H., Li, S., He, F., Tang, J., Chen, J., Zhou, Y., Xiao, R.*, 2024
- m6A reader Igf2bp3 enables germ plasm assembly by m6A-dependent regulation of gene expression in zebrafish, Ren, F., Miao, R., Xiao, R.*, Mei, J.*, 2021
- An emerging role of chromatin-interacting RNA-binding proteins in transcription regulation, Du, X., Xiao, R.*, 2020
- A Large-Scale Binding and Functional Map of Human RNA Binding Proteins, Van Nostrand, E., Freese, P., Pratt, G., Wang, X., Wei, X., Xiao, R., Blue, S., Chen, J., Cody, N., Dominguez, D., Olson, S., Sundararaman, B, Zhan, L., Bazile, C., Bouvrette, L., Bergalet, J., Duff, M., Garcia, K., Gelboin-Burkhart, C., Hochman, M., Lambert, N., Li, H., Nguyen, T., Palden, T., Rabano, I., Sathe, S., Stanton, R., Su, A., Wang, R., Yee, B., Zhou, B., Louie, A., Aigner, S., Fu, XD*, Lécuyer, E.*, Burge, C.*, Graveley, B.*, Yeo, G.*, 2020
- Expanded encyclopaedias of DNA elements in the human and mouse genomes, The ENCODE Project Consortium et al., 2020
- Perspectives on ENCODE, The ENCODE Project Consortium et al., 2020
- N(6)-methyladenosine co-transcriptionally directs the demethylation of histone H3K9me2, Li, Y., Xia, L., Tan, K., Ye, X., Zou, Z., Li, M., Xiao, R., Wang, Z., Liu, X., Deng, M., Cui, J., Yang, M., Luo, Q., Liu, S., Cao, X., Zhu, H., Liu, T., Hu, J., Shi, J., Xiao, S.*, Xia, L.*, 2020
- Igf2bp3 maintains maternal RNA stability and ensures early embryo development in zebrafish, Ren, F., Lin, Q., Gong, G., Du, X., Dan, H., Qin, W., Miao, R., Xiong, Y., Xiao, R., Li, X., Gui, J.*, Mei, J.*, 2020
- Pervasive Chromatin-RNA Binding Protein Interactions Enable RNA-based Regulation of Transcription, Xiao, R.*, Chen, JY, Liang, Z, Luo, D., Chen, G., Lu, Z., Chen, Y., Zhou, B., Li, H., Du, X., Yang, Y., San, M., Wei, X., Liu, W., Lecuyer, E., Graveley, B., Yeo, G., Burge, C., Zhang, M., Zhou, Y., Fu, XD*, 2019
- R-ChIP using inactive RNase H reveals dynamic Coupling of R-loops with transcriptional pausing at gene promoters, Chen, L., Chen, JY., Zhang, X., Gu, Y., Xiao, R., Shao, C., Tang, P., Qian, H., Luo, D., Li, H., Zhou, Y., Zhang, D., Fu, XD, 2017
- RBFox2 Binds Nascent RNA to Globally Regulate Polycomb Complex 2 Targeting in Mammalian Genomes, Wei, C., Xiao, R., Chen, L., Cui, H., Zhou, Y., Xue, Y., Hu, J., Zhou, B., Tsutsui, T., Qiu, J., Li, H., Tang, L., Fu, XD, 2016
- Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex, Wang, L., Zhou, Y., Xu, L., Xiao, R., Lu, X., Chen, L., Chong, J., He, C., Fu, XD, Wang, D., 2015
- SR proteins collaborate with 7SK and promoter-associated nascent RNA to release paused polymerase, Ji, X., Zhou, Y., Pandit, S., Huang, J., Li, H., Lin, C., Xiao, R., Burge, C.B., Fu, XD
- Nuclear matrix factor hnRNP U/SAF-A exerts a global control of alternative splicing by regulating U2 snRNP maturation, Xiao, R., Tang, P., Yang, B., Huang, J., Zhou, Y., Shao, C., Li, H., Sun, H., Zhang, Y., Fu, XD, 2012
Awards
- 2021: National 'Top Young Talents' under the Ten Thousand Talent Program
- 2020: Hubei Province 'BR Plan'
- 2019: Hubei Province 'Chutian Scholar' Distinguished Professor
