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Haojian Zhang
Immunology and Metabolion
Wuhan University
Hubei
Language: Chinese, English
Hematology
Cellular
Therapy
Epigenetics
Disease Mechanisms
Targeted Strategies
Immunotherapy
Acute Myeloid Leukemia
Transcriptional Regulation
Immune Evasion
Areas of Focus
- Hematologic diseases
- Cell therapy
- Epigenetic regulation
Work Experience
- 2004-2006 Assistant Researcher, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 2012-2016 Postdoctoral Fellow, Dana-Farber Cancer Institute, Harvard Medical School
- 2016-Present Professor, Medical Research Institute, Wuhan University
Academic Background & Achievements
- 1997-2001 Bachelor of Life Sciences, Shandong Normal University
- 2001-2004 Master of Cell Biology, Chinese Academy of Sciences
- 2008-2012 PhD in Tumor Biology, University of Massachusetts Medical School
Publications
- Decoding m6A RNA methylome identifies PRMT6-regulated lipid transport promotes AML stem cell maintenance, Zhang H et al., 2023
- Differential m6A RNA landscapes across hematopoiesis reveal a role for IGF2BP2 in preserving hematopoietic stem cell function, Zhang H et al., 2022
- Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis, Zhang H et al., 2020
- YBX1 is required for maintaining myeloid leukemia cell survival by regulating BCL2 stability in an m6A-dependent manner, Zhang H et al., 2021
- PTIP governs NAD+ metabolism by regulating CD38 expression to drive macrophage inflammation, Zhang H et al., 2022
- Pax transactivation domain-interacting protein is required for preserving hematopoietic stem cell quiescence via regulating lysosomal activity, Zhang H et al., 2023
- TGF-β inhibition rescues hematopoietic stem cell defects and bone marrow failure in fanconi anemia, Zhang H et al., 2016
- The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells, Zhang H et al., 2012
- HIF1α is required for survival maintenance of chronic myeloid leukemia stem cells, Zhang H et al., 2012
Awards
- National Science Fund for Distinguished Young Scholars
- National High-level Talents Youth Project
- Excellent Young Scientist Fund (NSFC)
- Outstanding Research Award, Chinese Scholars, Harvard University
- Leukemia & Lymphoma Society Fellow Award
