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Mengcheng Luo
Basic Medical Sciences
Wuhan University
Hubei
Language: Chinese, English
Infertility
Reproductive Health
Spermatogenesis
Testicular Aging
Reproductive Drugs
Assisted Reproduction
Gene Regulation
Stem Cells
Meiotic Recombination
Clinical Applications
Areas of Focus
- Infertility and reproductive health issues
- Spermatogenesis
- Testicular aging
- Reproductive regulation drugs
- Assisted reproductive technologies
Work Experience
- 2010-2016: Postdoctoral Researcher, University of Pennsylvania, USA, Reproductive Development
- 2016-present: Professor at Wuhan University, Basic Medical School
- 2022-present: PI at Taikang Life Medical Center
Academic Background & Achievements
- 2001-2005: Bachelor's Degree from Wuhan University, School of Life Sciences
- 2005-2010: PhD from Wuhan University, State Key Laboratory of Virology
- Selected for the National Talent Program
Publications
- SDX on the X chromosome is required for male sex determination, Mengcheng Luo, 2022
- Establish machine learning-based prediction models to guide the selection of Cas9 variants for efficient gene editing, Mengcheng Luo, 2024
- Histone methyltransferase DOT1L is essential for self-renewal of germline stem cells, Mengcheng Luo, 2022
- Skp1 Drives the Prophase I to Metaphase I Transition During Male Meiosis, Mengcheng Luo, 2020
- The DOT1L-MLLT10 complex regulates male fertility and promotes histone removal during spermiogenesis, Mengcheng Luo, 2023
- YTHDF1 promotes mRNA degradation via YTHDF1-AGO2 interaction and phase separation, Mengcheng Luo, 2022
- Meiob Exhibits Single-Stranded DNA-Binding and Exonuclease Activities and Is Essential for Meiotic Recombination, Mengcheng Luo, 2013
- Polycomb Protein Scml2 Associates with Usp7 and Counteracts Histone H2a Ubiquitination in the XY Chromatin During Male Meiosis, Mengcheng Luo, 2015
Awards
- 2017: Second Prize, Hubei Province Science and Technology Progress Award, Mother-Fetus Immune Regulation
- 2017: Second Prize, National Maternal and Child Health Science and Technology Award, Unexplained Recurrent Miscarriage
- 2018: Second Prize, Chinese Medical Association Science and Technology Award, Mother-Fetus Immune Regulation
- 2018: Third Prize, Huaxia Medical Science and Technology Award, Mother-Fetus Immune Regulation
