Professor | Mengcheng Luo | Asia Growth Partners

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Name	Mengcheng Luo
Contact Information	luomengcheng@whu.edu.cn
Language ability	Chinese, English
Province	Hubei

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Name

Mengcheng Luo

Contact Information

luomengcheng@whu.edu.cn

Language ability

Chinese, English

Province

Hubei

University/Lab Affiliation and Title	Wuhan University
Faculty	Basic Medical Sciences
Academic Background & Achievements	2001-2005: Bachelor's Degree from Wuhan University, School of Life Sciences 2005-2010: PhD from Wuhan University, State Key Laboratory of Virology Selected for the National Talent Program
Work Experience	2010-2016: Postdoctoral Researcher, University of Pennsylvania, USA, Reproductive Development 2016-present: Professor at Wuhan University, Basic Medical School 2022-present: PI at Taikang Life Medical Center
Awards	2017: Second Prize, Hubei Province Science and Technology Progress Award, Mother-Fetus Immune Regulation 2017: Second Prize, National Maternal and Child Health Science and Technology Award, Unexplained Recurrent Miscarriage 2018: Second Prize, Chinese Medical Association Science and Technology Award, Mother-Fetus Immune Regulation 2018: Third Prize, Huaxia Medical Science and Technology Award, Mother-Fetus Immune Regulation

University/Lab Affiliation and Title

Wuhan University

Faculty

Basic Medical Sciences

Academic Background & Achievements

2001-2005: Bachelor's Degree from Wuhan University, School of Life Sciences
2005-2010: PhD from Wuhan University, State Key Laboratory of Virology
Selected for the National Talent Program

Work Experience

2010-2016: Postdoctoral Researcher, University of Pennsylvania, USA, Reproductive Development
2016-present: Professor at Wuhan University, Basic Medical School
2022-present: PI at Taikang Life Medical Center

Awards

2017: Second Prize, Hubei Province Science and Technology Progress Award, Mother-Fetus Immune Regulation
2017: Second Prize, National Maternal and Child Health Science and Technology Award, Unexplained Recurrent Miscarriage
2018: Second Prize, Chinese Medical Association Science and Technology Award, Mother-Fetus Immune Regulation
2018: Third Prize, Huaxia Medical Science and Technology Award, Mother-Fetus Immune Regulation

Areas of Focus	Infertility and reproductive health issues Spermatogenesis Testicular aging Reproductive regulation drugs Assisted reproductive technologies
Publications	SDX on the X chromosome is required for male sex determination, Mengcheng Luo, 2022 Establish machine learning-based prediction models to guide the selection of Cas9 variants for efficient gene editing, Mengcheng Luo, 2024 Histone methyltransferase DOT1L is essential for self-renewal of germline stem cells, Mengcheng Luo, 2022 Skp1 Drives the Prophase I to Metaphase I Transition During Male Meiosis, Mengcheng Luo, 2020 The DOT1L-MLLT10 complex regulates male fertility and promotes histone removal during spermiogenesis, Mengcheng Luo, 2023 YTHDF1 promotes mRNA degradation via YTHDF1-AGO2 interaction and phase separation, Mengcheng Luo, 2022 Meiob Exhibits Single-Stranded DNA-Binding and Exonuclease Activities and Is Essential for Meiotic Recombination, Mengcheng Luo, 2013 Polycomb Protein Scml2 Associates with Usp7 and Counteracts Histone H2a Ubiquitination in the XY Chromatin During Male Meiosis, Mengcheng Luo, 2015

Areas of Focus

Infertility and reproductive health issues
Spermatogenesis
Testicular aging
Reproductive regulation drugs
Assisted reproductive technologies

Publications

SDX on the X chromosome is required for male sex determination, Mengcheng Luo, 2022
Establish machine learning-based prediction models to guide the selection of Cas9 variants for efficient gene editing, Mengcheng Luo, 2024
Histone methyltransferase DOT1L is essential for self-renewal of germline stem cells, Mengcheng Luo, 2022
Skp1 Drives the Prophase I to Metaphase I Transition During Male Meiosis, Mengcheng Luo, 2020
The DOT1L-MLLT10 complex regulates male fertility and promotes histone removal during spermiogenesis, Mengcheng Luo, 2023
YTHDF1 promotes mRNA degradation via YTHDF1-AGO2 interaction and phase separation, Mengcheng Luo, 2022
Meiob Exhibits Single-Stranded DNA-Binding and Exonuclease Activities and Is Essential for Meiotic Recombination, Mengcheng Luo, 2013
Polycomb Protein Scml2 Associates with Usp7 and Counteracts Histone H2a Ubiquitination in the XY Chromatin During Male Meiosis, Mengcheng Luo, 2015

Infertility Reproductive Health Spermatogenesis Testicular Aging Reproductive Drugs Assisted Reproduction Gene Regulation Stem Cells Meiotic Recombination Clinical Applications

Bai Yun - Peking University

Changyong Li - Wuhan University

Yinzi - Zhejiang University

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