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Jing Yang
Basic Medical Sciences
Wuhan University
Hubei
Language: Chinese, English
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Lipid Metabolism Cell Membrane Tumor Angiogenesis Metastasis Arachidonic Acid Cox Lox Cyp Enzymes Biological Activity Disease Processes Drug Targets Traditional Chinese Medicine Structural Modification Pharmacodynamics Toxicology Multi-Target Drugs Synergistic Effects Side Effects Drug Development Clinical Trials
Areas of Focus
  • Functional studies of important lipid metabolites in cell membranes
  • Innovative drug research and development
Work Experience
  • 2007-present: Professor, Deputy Head of Department, Pharmacology Department, School of Basic Medical Sciences, Wuhan University
  • 2002-2006: Associate Professor, Deputy Head of Department, Pharmacology Department, Medical School, Wuhan University
  • 2006: Research Fellow, Department of Pharmacology, Fukushima Medical University, Japan
  • 1990-1998: Physician, Senior Physician, Clinical Pharmacology Laboratory, Hubei Institute of Geriatrics
Academic Background & Achievements
  • 1998-2001: PhD in Internal Medicine, Wuhan University
  • 1987-1990: Master in Pathogenic Biology, Hubei Medical University
  • 1982-1987: Bachelor in Clinical Medicine, Hubei Medical University
Publications
  • CYP4A in tumor-associated macrophages promotes pre-metastatic niche formation and metastasis, Yang J et al., 2017
  • Inhibition of CYP4A by a novel flavonoid FLA-16 prolongs survival and normalizes tumor vasculature in glioma, Yang J et al., 2017
  • 20-HETE regulates the angiogenic functions of human endothelial progenitor cells and contributes to angiogenesis in vivo, Yang J et al., 2014
  • Isoliquiritigenin, a flavonoid from licorice, blocks M2 macrophage polarization in colitis-associated tumorigenesis through downregulating PGE2 and IL-6, Yang J et al., 2014
  • Downregulation of COX-2 and CYP 4A signaling by isoliquiritigenin inhibits human breast cancer metastasis through preventing anoikis resistance, migration and invasion, Yang J et al., 2014
  • Isoliquiritigenin induces growth inhibition and apoptosis through downregulating arachidonic acid metabolic network and the deactivation of PI3K/Akt in human breast cancer, Yang J et al., 2013
  • Increased expression of CYP4Z1 promotes tumor angiogenesis and growth in human breast cancer, Yang J et al., 2012
  • Antitumor and immunostimulatory activity of a polysaccharide–protein complex from Scolopendra subspinipes mutilans L. Koch in tumor-bearing mice, Yang J et al., 2012
  • Cytochrome P450 ω-hydroxylase promotes angiogenesis and metastasis by upregulation of VEGF and MMP-9 in non-small cell lung cancer, Yang J et al., 2011
  • Protective effects of isoliquiritigenin in transient middle cerebral artery occlusion-induced focal cerebral ischemia in rats, Yang J et al., 2006
Awards
  • 2011: New Drug Certificate and Production License for Valtrate Extract and Spasmolysis Capsule (Drug Approval Number: Z20110032; Drug Registration Number: 2011S00735)
  • 2006: Third Prize, Wuhan Science and Technology Progress Award for the clinical and experimental study of Pinglv Compound in treating arrhythmia
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