Professor | Jie Xu | Asia Growth Partners

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Name	Jie Xu
Contact Information	xj_nju@126.com
Language ability	Chinese, English
Province	Hubei

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Name

Jie Xu

Contact Information

xj_nju@126.com

Language ability

Chinese, English

Province

Hubei

University/Lab Affiliation and Title	Wuhan University
Faculty	Basic Medical Sciences
Academic Background & Achievements	2006-09 to 2010-06, Nanjing University, School of Life Sciences, Biology, Bachelor 2010-09 to 2015-06, Nanjing University, School of Life Sciences, Biochemistry, PhD 2013-07 to 2015-06, Harvard Medical School, BIDMC, Department of Endocrinology, Neuro and Metabolism, PhD (Joint Training)
Work Experience	2015-08 to 2021-02, Tufts University, Department of Neurobiology, Postdoctoral Researcher 2021-03 to 2023-09, Harvard Medical School, Boston Children's Hospital, Department of Endocrinology, Instructor 2023-10 to present, Wuhan University, Taikang Medical College (Basic Medical College), Professor

University/Lab Affiliation and Title

Wuhan University

Faculty

Basic Medical Sciences

Academic Background & Achievements

2006-09 to 2010-06, Nanjing University, School of Life Sciences, Biology, Bachelor
2010-09 to 2015-06, Nanjing University, School of Life Sciences, Biochemistry, PhD
2013-07 to 2015-06, Harvard Medical School, BIDMC, Department of Endocrinology, Neuro and Metabolism, PhD (Joint Training)

Work Experience

2015-08 to 2021-02, Tufts University, Department of Neurobiology, Postdoctoral Researcher
2021-03 to 2023-09, Harvard Medical School, Boston Children's Hospital, Department of Endocrinology, Instructor
2023-10 to present, Wuhan University, Taikang Medical College (Basic Medical College), Professor

Areas of Focus	Molecular mechanisms of leptin resistance Functional study of feeding signals in obesity and anorexia Central regulatory mechanisms of cachexia Central regulation of blood glucose
Publications	Genetic identification of leptin neural circuits in energy and glucose homeostasis, Jie Xu, Bartolome CL, Low CS, Yi X, Chien CH, Wang P, Kong D, 2018 Synaptosomes secrete and uptake functionally active microRNAs via exocytosis and endocytosis pathways, Jie Xu, Chen Q, Zen K, Zhang C, Zhang Q, 2013 Small RNA existed in commercial reverse transcriptase: primary evidence of functional small RNAs, Jie Xu, Xi Chen, Donghai Li, Qun Chen, Zhen Zhou, Dongxia Hou, Jin Wang, Qipeng Zhang, Ke Zen, Chen-Yu Zhang, 2014 MicroRNA-23a/b and microRNA-27a/b suppress Apaf-1 protein and alleviate hypoxia-induced neuronal apoptosis, Q Chen, Jie Xu, L Li, H Li, S Mao, F Zhang, K Zen, CY Zhang, Q Zhang, 2014 Selective secretion of microRNA in CNS system, Zhang Q, Jie Xu, Chen Q, Chen X, Zen K, Zhang CY, 2014 Identification and characterization of the MicroRNA profile in aging rats with erectile dysfunction, Pan F, Jie Xu, Zhang Q, Qiu X, Yu W, Jiadong Xia, Taowei Chen, Lianjun Pan, Yun Chen, Yutian Dai, 2014 SIDT1dependent absorption in the stomach mediates host uptake of dietary and orally administered microRNAs, Chen Q, Zhang F, Dong L, Wu H, Jie Xu, Li H, Wang J, Zhou Z, Liu C, Wang Y, Liu Y, Lu L, Wang C, Liu M, Chen X, Wang C, Zhang C, Li D, Zen K, Wang F, Zhang Q, Zhang CY, 2020 A rapidly acting glutamatergic ARC→PVH satiety circuit postsynaptically regulated by αMSH, Henning Fenselau, John N Campbell, Anne MJ Verstegen, Joseph C Madara, Jie Xu, Bhavik P Shah, Jon M Resch, Zongfang Yang, Yael Mandelblat-Cerf, Yoav Livneh, Bradford B Lowell, 2017 PNOCARC Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding, Jais A, Paeger L, Sotelo-Hitschfeld T, Bremser S, Prinzensteiner M, Klemm P, Mykytiuk V, Widdershooven PJM, Vesting AJ, Grzelka K, Minère M, Cremer AL, Jie Xu, Korotkova T, Lowell BB, Zeilhofer HU, Backes H, Fenselau H, Wunderlich FT, Kloppenburg P, Brüning JC, 2020 Anterior thalamic dysfunction underlies cognitive deficits in a subset of neuropsychiatric disease models, Dheeraj S Roy, Ying Zhang, Tomomi Aida, Soonwook Choi, Qian Chen, Yuanyuan Hou, Nicholas E Lea, Keith M Skaggs, Juliana C Quay, Min Liew, Vinh Le, Carter Jones, Jie Xu, Dong Kong, Heather A Sullivan, Arpiar Saunders, Steven A McCarroll, Ian R Wickersham, Guoping Feng, 2021

Areas of Focus

Molecular mechanisms of leptin resistance
Functional study of feeding signals in obesity and anorexia
Central regulatory mechanisms of cachexia
Central regulation of blood glucose

Publications

Genetic identification of leptin neural circuits in energy and glucose homeostasis, Jie Xu, Bartolome CL, Low CS, Yi X, Chien CH, Wang P, Kong D, 2018
Synaptosomes secrete and uptake functionally active microRNAs via exocytosis and endocytosis pathways, Jie Xu, Chen Q, Zen K, Zhang C, Zhang Q, 2013
Small RNA existed in commercial reverse transcriptase: primary evidence of functional small RNAs, Jie Xu, Xi Chen, Donghai Li, Qun Chen, Zhen Zhou, Dongxia Hou, Jin Wang, Qipeng Zhang, Ke Zen, Chen-Yu Zhang, 2014
MicroRNA-23a/b and microRNA-27a/b suppress Apaf-1 protein and alleviate hypoxia-induced neuronal apoptosis, Q Chen, Jie Xu, L Li, H Li, S Mao, F Zhang, K Zen, CY Zhang, Q Zhang, 2014
Selective secretion of microRNA in CNS system, Zhang Q, Jie Xu, Chen Q, Chen X, Zen K, Zhang CY, 2014
Identification and characterization of the MicroRNA profile in aging rats with erectile dysfunction, Pan F, Jie Xu, Zhang Q, Qiu X, Yu W, Jiadong Xia, Taowei Chen, Lianjun Pan, Yun Chen, Yutian Dai, 2014
SIDT1dependent absorption in the stomach mediates host uptake of dietary and orally administered microRNAs, Chen Q, Zhang F, Dong L, Wu H, Jie Xu, Li H, Wang J, Zhou Z, Liu C, Wang Y, Liu Y, Lu L, Wang C, Liu M, Chen X, Wang C, Zhang C, Li D, Zen K, Wang F, Zhang Q, Zhang CY, 2020
A rapidly acting glutamatergic ARC→PVH satiety circuit postsynaptically regulated by αMSH, Henning Fenselau, John N Campbell, Anne MJ Verstegen, Joseph C Madara, Jie Xu, Bhavik P Shah, Jon M Resch, Zongfang Yang, Yael Mandelblat-Cerf, Yoav Livneh, Bradford B Lowell, 2017
PNOCARC Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding, Jais A, Paeger L, Sotelo-Hitschfeld T, Bremser S, Prinzensteiner M, Klemm P, Mykytiuk V, Widdershooven PJM, Vesting AJ, Grzelka K, Minère M, Cremer AL, Jie Xu, Korotkova T, Lowell BB, Zeilhofer HU, Backes H, Fenselau H, Wunderlich FT, Kloppenburg P, Brüning JC, 2020
Anterior thalamic dysfunction underlies cognitive deficits in a subset of neuropsychiatric disease models, Dheeraj S Roy, Ying Zhang, Tomomi Aida, Soonwook Choi, Qian Chen, Yuanyuan Hou, Nicholas E Lea, Keith M Skaggs, Juliana C Quay, Min Liew, Vinh Le, Carter Jones, Jie Xu, Dong Kong, Heather A Sullivan, Arpiar Saunders, Steven A McCarroll, Ian R Wickersham, Guoping Feng, 2021

Leptin Resistance Molecular Obesity Anorexia Feeding Signals Cachexia Blood Glucose

Fang Wang - Peking Union Medical College

Fang Wang - Peking Union Medical College

Zhang Deling - Wuhan University

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