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Guohua Yang
Basic Medical Sciences
Wuhan University
Hubei
Language: Chinese, English
Genetic Diseases
Gene Mutations
Functional Research
Genetic Diagnosis
New Methods
Liver Cancer
Molecular Mechanisms
Drug Discovery
Biomedical Research
Clinical Applications
Areas of Focus
- Functional research on genetic mutations in genetic diseases
- Research on new methods of genetic diagnosis
- Molecular mechanisms and drug discovery in liver cancer
Work Experience
- 2011-present: Associate Professor at Wuhan University School of Basic Medical Sciences
- 2014-2015: Visiting Scholar at Cleveland Medical Center, USA
- 2006-2010: Lecturer at Wuhan University School of Basic Medical Sciences
- 2010-2011: Deputy Director at Suizhou City Health Bureau, Hubei Province
- 1995-1999: Biology Teacher at Wuhan Iron and Steel Ninth Middle School
Academic Background & Achievements
- 1992-1995: Associate Degree in Biology from Hubei Engineering College (formerly Xiaogan Teachers College)
- 2001-2006: Master and PhD in Genetics from Wuhan University
Publications
- Truncated FRMD7 Proteins in Congenital Nystagmus: Novel Frameshift Mutations and Proteasomal Pathway Implications, Guohua Yang et al., 2024
- Autophagy inhibition mediated by trillin promotes apoptosis in hepatocellular carcinoma cells via activation of mTOR/STAT3 signaling, Guohua Yang et al., 2023
- Double-network cellulose-based hybrid hydrogels with favourable biocompatibility and antibacterial activity for wound healing, Guohua Yang et al., 2023
- Machine learning-based transcriptome analysis of lipid metabolism biomarkers for the survival prediction in hepatocellular carcinoma, Guohua Yang et al., 2022
- DJ-1/FGFR-1 Signaling Pathway Contributes to Sorafenib Resistance in Hepatocellular Carcinoma, Guohua Yang et al., 2022
- C1R, CL2, and TNFRSF1A Genes in Coronavirus Disease-COVID-19 Pathway Serve as Novel Molecular Biomarkers of GBM Prognosis and Immune Infiltration, Guohua Yang et al., 2022
- Berberine exerts its antineoplastic effects by reversing the Warburg effect via downregulation of the Akt/mTOR/GLUT1 signaling pathway, Guohua Yang et al., 2021
- Dissecting Tumor Antigens and Immune Subtypes of Glioma to Develop mRNA Vaccine, Guohua Yang et al., 2021
- A novel TSC1 frameshift mutation c.1550_1551del causes tuberous sclerosis complex by aberrant splicing and nonsense-mediated mRNA degradation (NMD) simultaneously in a Chinese family, Guohua Yang et al., 2020
- Trillin prevents proliferation and induces apoptosis through inhibiting STAT3 nuclear translocation in hepatoma carcinoma cells, Guohua Yang et al., 2020
- Identification and Interaction Analysis of Significant Genes and MicroRNAs in Pterygium, Guohua Yang et al., 2019
Awards
- 2006: Outstanding Young (Student) at Wuhan University
- 2009: Excellent Guide Teacher for Wuhan University Students' Summer Social Practice
- 2014: Second Prize at the 'Chunhui Cup' Chinese Overseas Innovation and Entrepreneurship Competition, New York Area
- 2017: Most Potential Award at the 'Huachuang Cup' Innovation and Entrepreneurship Competition, Biomedical Field
- 2019: Outstanding Party Worker at Wuhan University School of Basic Medical Sciences
- 2021: Outstanding Class Tutor at Wuhan University School of Basic Medical Sciences
- 2021: Wuhan University Teaching Achievement Award (Professional Theory Class Category)
- 2021 and 2022: First Prize at Wuhan University in the 'Internet+' College Students Innovation and Entrepreneurship Competition, Silver Prize in Hubei Province
- 2023: 'Gold Award' at Wuhan University Staff Innovation and Entrepreneurship Competition
- 2023: 'Top Ten Entrepreneurs of Hubei Province' at the Sixth Hubei Provincial Education, Science, Culture, Health, and Sports System Staff Entrepreneurship and Innovation Finals
