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Bo Bai
Medical School
Southern University of Science and Technology
Guangdong
Language: Chinese, English
Endothelial Aging
Coronary Heart Disease
Molecular Mechanisms
Population Cohort
Model Animals
Multi-Omics
Heart Failure
Immune System
Cardiovascular System
Drug Targets
Areas of Focus
- Molecular pathophysiological mechanisms of coronary heart disease caused by endothelial aging based on population cohort data, model animals, and multi-omics studies
- Pathogenesis of heart failure from the interaction between the immune system and cardiovascular system, searching for new drug intervention targets
Work Experience
- 2022/07-Present, Southern University of Science and Technology, School of Public Health and Emergency Management, Research Assistant Professor
- 2019/06-2022/06, Shenzhen Second People's Hospital, Department of Cardiology, Full-time Researcher
- 2016/09-2020/08, The University of Hong Kong, Li Ka Shing Faculty of Medicine, Honorary Assistant Professor (part-time)
- 2005/08-2009/08, Beijing China-Japan Friendship Hospital, Department of Pharmacy, Clinical Pharmacist
Academic Background & Achievements
- 2005-2009 Bachelor and Master in Cardiovascular Pharmacology, Sichuan University, West China School of Pharmacy
- 2009-2014 PhD in Cardiovascular Biomedicine, The University of Hong Kong, Li Ka Shing Faculty of Medicine
- 2014-2019 Postdoctoral Fellow in Cardiovascular Biomedicine, A*STAR, Singapore
Publications
- Pathogenic roles of neutrophil-derived alarmins (S100A8/A9) in heart failure: from molecular mechanisms to therapeutic insights, Bo BAI, Yun Xu, Haibo Chen, 2022
- High neutrophil to lymphocyte ratio and its gene signatures correlate with diastolic dysfunction in heart failure with preserved ejection fraction, Bo BAI, Min Cheng, Lingyan Jiang, et al., 2021
- Metformin: A novel weapon against inflammation, Bo BAI, Haibo Chen, 2021
- The pregnancy-associated spontaneous coronary artery dissection in a young woman with a novel missense mutation in NOTCH1: a case report, Bo BAI, Meng Zhang, Yihao Zhuang, et al., 2020
- Seipin knockout mice develop heart failure with preserved ejection fraction, Bo BAI, Wulin Yang, Yanyun Fu, et al., 2019
- CDK5, YM Guo, Yu Wang, Bo BAI, 2018
- Cloning and characterization of sirtuin3 (SIRT3), AW Man, Bo BAI, Yu Wang, 2016
- Loss of SIRT1 function during vascular ageing: hyperphosphorylation mediated by cyclin-dependent kinase 5, Bo BAI, Vanhoutte PM, Yu Wang, 2014
- Methods to investigate the role of SIRT1 in endothelial senescence, Bo BAI, Yu Wang, 2012
- Cyclin-dependent kinase 5-mediated hyperphosphorylation of sirtuin-1 contributes to the development of endothelial senescence and atherosclerosis, Bo BAI, Yan Liang, Cheng Xu, et al., 2012
- The use of lorcaserin in the management of obesity: a critical appraisal, Bo BAI, Yu Wang, 2011
