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Jianyang Hu
Medical School
Southern University of Science and Technology
Guangdong
Language: Chinese, English
Senescence
Tumor Cells
Cellular Communication
Exosomes
Metastasis
Tumor Microenvironment
Cell Signaling
Cancer Therapy
Drug Targets
Molecular Biology
Areas of Focus
- Regulation of tumor cell senescence
- Mechanisms of tumor metastasis
- Intercellular communication in the tumor microenvironment, such as exosome-mediated communication
Work Experience
- 2023.08-present Assistant Research Professor, Southern University of Science and Technology, School of Medicine
- 2021.07-2023.07 Postdoctoral Researcher, Southern University of Science and Technology, School of Medicine
- 2020.10-2021.06 Postdoctoral Researcher, City University of Hong Kong, Department of Biomedical Sciences
- 2017.02-2017.08 Research Assistant, City University of Hong Kong, Department of Biomedical Sciences
Academic Background & Achievements
- 2017.09-2020.10 PhD, Biomedical Sciences, City University of Hong Kong
- 2012.09-2015.06 Master's, Pharmacology, Jinan University
- 2008.09-2012.06 Bachelor's, Pharmacy, Guangzhou University of Chinese Medicine
Publications
- Defining super-enhancer landscape in triple-negative breast cancer by multiomic profiling, Huang H, Hu JY, et al., 2021
- TCOF1 upregulation in triple-negative breast cancer promotes stemness and tumor growth, and correlates with poor prognosis, Hu JY, Lai Y, et al., 2022
- Nitazoxanide impairs mitophagy flux through ROS-mediated mitophagy initiation and lysosomal dysfunction in bladder cancer, Sun HY, Hu JY, et al., 2021
- Ailanthone Inhibits Huh7 Cancer Cell Growth via Cell Cycle Arrest and Apoptosis In Vitro and In Vivo, Zhuo ZZ, Hu JY, et al., 2015
- Phase-separated condensate-aided enrichment of biomolecular interactions for high-throughput drug screening in test tubes, Zhou M, Li WP, Hu JY, et al., 2020
- Aloperine induces apoptosis and G2/M cell cycle arrest in hepatocellular carcinoma cells through the PI3K/Akt signaling pathway, Liu JS, Huo CY, Hu JY, et al., 2019
- The cycloartane triterpenoid ADCX impairs autophagic degradation through Akt overactivation and promotes apoptotic cell death in multidrug-resistant HepG2/ADM cells, Sun HY, Huang MH, Hu JY, et al., 2017
- Arenobufagin inhibits prostate cancer epithelial-mesenchymal transition and metastasis by down-regulating β-catenin, Chen LP, Mai WQ, Hu JY, et al., 2017
- Targeting tumor pericytes with a FAP-alpha-activated prodrug combats tumor resistance to vascular disrupting agents, Chen MF, Lei XP, Hu JY, et al., 2017
- In vitro and in vivo antiangiogenic activity of desacetylvinblastine monohydrazide through inhibition of VEGFR2 and Axl pathways, Lei XP, Chen MF, Hu JY, et al., 2016
- New cycloartane triterpenoid from Cimicifuga foetida induces mitochondrial apoptosis in human breast carcinoma MCF-7 cells via inhibiting Raf/MEK/ERK pathway and Akt phosphorylation, Sun HY, Liu BB, Hu JY, et al., 2016
- Geleganidines A–C, Unusual Monoterpenoid Indole Alkaloids from Gelsemium elegans, Zhang W, Huang XJ, Hu JY, et al., 2015
- Bufalin induces apoptosis of MDA-MB-231 cell through activation of JNK/p53 pathway, Hu JY, Chen MF, Lei XP, et al., 2015
Awards
- National Natural Science Foundation of China (Youth Project)
- Shenzhen Science and Innovation Commission - Excellent Science and Technology Innovation Talent Training Project (Youth Project)
- China Postdoctoral Science Foundation Grant
- Guangdong Province Overseas Postdoctoral Talent Support Project
