2007-2011: Bachelor of Science in Biological Sciences, Lanzhou University
2011-2017: PhD in Biochemistry and Molecular Biology, Lanzhou University
Joint PhD in Neuroscience, Duke University
Published 49 SCI papers, cited over 1900 times, H-index of 23
Filed 8 national invention patents, 5 granted
2017.01-2017.10: Visiting Student, Department of Anesthesiology, Duke University Medical School
2017.10-2021.01: Postdoctoral Research Fellow, Department of Anesthesiology, Duke University Medical School
2021.03-present: Assistant Professor, Doctoral Supervisor, Southern University of Science and Technology
2015: National Scholarship
2017: Outstanding Graduate of Lanzhou University
Member of the Editorial Board
2017-present: Member, Society for Neuroscience
Research
Molecular and neural mechanisms of pain and itch perception Development of analgesic and antipruritic drugs Neural mechanisms and new targets for pain and itch Immune-neural interactions Cellular and molecular mechanisms of pathological pain and its clinical treatment
Cryo-EM structures of the human NaS1 and NaDC1 transporters revealed the elevator transport and allosteric regulation mechanism, Ximin Chi, Yiming Chen, Yaning Li, Lu Dai, Yuanyuan Zhang, Yaping Shen, Yun Chen, Tianhao Shi, Haonan Yang, Zilong Wang, Renhong Yan, 2024
Satellite glial GPR37L1 and its ligand maresin 1 regulate potassium channel signaling and pain homeostasis, Sangsu Bang, Changyu Jiang, Jing Xu, Sharat Chandra, Aidan McGinnis, Xin Luo, Qianru He, Yize Li, Zilong Wang, Xiang Ao, Marc Parisien, Lorenna Oliveira Fernandes de Araujo, Sahel Jahangiri Esfahan, Qin Zhang, Raquel Tonello, Temugin Berta, Luda Diatchenko, Ru-Rong Ji, 2024
Disruption of the Na+/K+-ATPase-purinergic P2X7 receptor complex in microglia promotes stress-induced anxiety, Songqiang Huang, Wanting Dong, Xiaoqian Lin, Kangtai Xu, Kun Li, Siping Xiong, Zilong Wang, Xiaowei Nie, Jin-Song Bian, 2024
Injured sensory neurons-derived Galectin-3 contributes to neuropathic pain via programming microglia in the spinal dorsal horn, Leyan Shan, Kangtai Xu, Luyao Ji, Qian Zeng, Yaqi Liu, Yifei Wu, Yiming Chen, Yitong Li, Qiaodan Hu, Jiawei Wu, Yuanfan Xu, Yuhui Luo, Changlin Li, Chaoran Wu, Changyu Jiang, Zilong Wang, 2024
Structural insight into the substrate recognition and transport mechanism of amino acid transporter complex ACE2-B0AT1 and ACE2-SIT1, Yaning Li, Yiming Chen, Yuanyuan Zhang, Yaping Shen, Kangtai Xu, Yaqi Liu, Zilong Wang, Renhong Yan, 2023
Silencing of TRPV4-expressing sensory neurons attenuates temporomandibular disorders pain, Fabiana C Dias, Zilong Wang, Garrett Scapellato, Yong Chen, 2023
Microglial Cannabinoid CB(2) Receptors in Pain Modulation, K. Xu, Y. Wu, Z. Tian, Y. Xu, C. Wu, Z. Wang, 2023
Up-regulation of oxytocin receptors on peripheral sensory neurons mediates analgesia in chemotherapy-induced neuropathic pain, L. Li, P. Li, J. Guo, Y. Wu, Q. Zeng, N. Li, X. Huang, Y. He, W. Ai, W. Sun, T. Liu, D. Xiong, L. Xiao, Y. Sun, Q. Zhou, H. Kuang, Z. Wang, C. Jiang, 2023
Involvement of Sensory Neurone-TRPV4 in Acute and Chronic Itch Behaviours, Qiaojuan Zhang, Fabiana Dias, Quan Fang, Gwendolyn Henry, Zilong Wang, Abbie Suttle, Yong Chen, 2022
Skin Injury Activates a Rapid TRPV1-Dependent Antiviral Protein Response, Vivian Lei, Chelsea Handfield, Jeffery T. Kwock, Stephen J. Kirchner, Min Jin Lee, Margaret Coates, Kaiyuan Wang, Qingjian Han, Zilong Wang, Jennifer G. Powers, Sarah Wolfe, David L. Corcoran, Brian Fanelli, Manoj Dadlani, Ru-Rong Ji, Jennifer Y. Zhang, Amanda S. MacLeod, 2022
Emerging Role of PD-1 in the Central Nervous System and Brain Diseases, Junli Zhao, Alexus Roberts, Zilong Wang, Justin Savage, Ru-Rong Ji, 2021
Repurposing cancer drugs identifies kenpaullone which ameliorates pathologic pain in preclinical models via normalization of inhibitory neurotransmission, Michele Yeo, Yong Chen, Changyu Jiang, Gang Chen, Kaiyuan Wang, Sharat Chandra, Andrey Bortsov, Maria Lioudyno, Qian Zeng, Peng Wang, Zilong Wang, Jorge Busciglio, Ru-Rong Ji, Wolfgang Liedtke, 2021
The Parabrachial Nucleus as a Key Regulator of Neuropathic Pain, Zilong Wang, Zhen-Zhong Xu, 2021
Central opioid receptors mediate morphine-induced itch and chronic itch via disinhibition, Zilong Wang, Changyu Jiang, Hongyu Yao, Ouyang Chen, Sreya Rahman, Yun Gu, Junli Zhao, Yul Huh, Ru-Rong Ji, 2021
IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice, Xin Luo, Ouyang Chen, Zilong Wang, Sangsu Bang, Jasmine Ji, Sang Hoon Lee, Yul Huh, Kenta Furutani, Qianru He, Xueshu Tao, Mei-Chuan Ko, Andrey Bortsov, Christopher R. Donnelly, Yong Chen, Andrea Nackley, Temugin Berta, Ru-Rong Ji, 2021
STING controls nociception via type I interferon signalling in sensory neurons, Christopher R. Donnelly, Changyu Jiang, Amanda S. Andriessen, Kaiyuan Wang, Zilong Wang, Huiping Ding, Junli Zhao, Xin Luo, Michael S. Lee, Yu L. Lei, William Maixner, Mei-Chuan Ko, Ru-Rong Ji, 2021
Epithelia-Sensory Neuron Cross Talk Underlies Cholestatic Itch Induced by Lysophosphatidylcholine, Yong Chen, Zi-Long Wang, Michele Yeo, Qiao-Juan Zhang, Ana E. Lopez-Romero, Hui-Ping Ding, Xin Zhang, Qian Zeng, Sara L. Morales-Lazaro, Carlene Moore, Ying-Ai Jin, Huang-He Yang, Johannes Morstein, Andrey Bortsov, Marcin Krawczyk, Frank Lammert, Manal Abdelmalek, Anna Mae Diehl, Piotr Milkiewicz, Andreas E. Kremer, Jennifer Y. Zhang, Andrea Nackley, Tony E. Reeves, Mei-Chuan Ko, Ru-Rong Ji, Tamara Rosenbaum, Wolfgang Liedtke, 2021
Activation of GPR37 in macrophages confers protection against infection-induced sepsis and pain-like behaviour in mice, Sangsu Bang, Christopher R. Donnelly, Xin Luo, Maria Toro-Moreno, Xueshu Tao, Zilong Wang, Sharat Chandra, Andrey V. Bortsov, Emily R. Derbyshire, Ru-Rong Ji, 2021
The multifunctional peptide DN-9 produced peripherally acting antinociception in inflammatory and neuropathic pain via mu- and kappa-opioid receptors, Biao Xu, Mengna Zhang, Xuerui Shi, Run Zhang, Dan Chen, Yong Chen, Zilong Wang, Yu Qiu, Ting Zhang, Kangtai Xu, Xiaoyu Zhang, Wolfgang Liedtke, Rui Wang, Quan Fang, 2020
Spinal DN-9, a Peptidic Multifunctional Opioid/Neuropeptide FF Agonist Produced Potent Nontolerance Forming Analgesia With Limited Side Effects, Zilong Wang, Biao Xu, Changyu Jiang, Ting Zhang, Mengna Zhang, Ning Li, Qinqin Zhang, Kangtai Xu, Dan Chen, Jian Xiao, Quan Fang, 2020
Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel, Yang Suo, Zilong Wang, Lejla Zubcevic, Allen L. Hsu, Qianru He, Mario J. Borgnia, Ru-Rong Ji, Seok-Yong Lee, 2020
