Professor | Ying Wang | Asia Growth Partners

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Name	Ying Wang
Contact Information	wangy6@sustech.edu.cn
Language ability	Chinese, English
Province	Guangdong

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Name

Ying Wang

Contact Information

wangy6@sustech.edu.cn

Language ability

Chinese, English

Province

Guangdong

University/Lab Affiliation and Title	Southern University of Science and Technology
Faculty	Medical School
Academic Background & Achievements	2008-2012 Bachelor in Pharmaceutical Engineering: Guizhou University 2012-2017 PhD in Cardiovascular Pharmacology: Fudan University Published over ten research papers as first author in the field of cardiology
Work Experience	2017-2022 Postdoctoral Researcher at University of California, Davis 2022-present Associate Professor at Southern University of Science and Technology
Awards	2012 Guizhou Province Outstanding Graduate 2012 Fudan University PhD Freshman Scholarship 2013 Fudan University Cross-disciplinary Excellent PhD Student Research Award 2014 9th PharmSci@Asia Forum, Paper Award 2015 Shanghai Pharmacological Society Young Scholar Forum, Excellent Paper Award 2015 Yangtze Delta Region Forum on Life Sciences and Human Health, First Prize 2016 Society for Laboratory Automation and Screening (SLAS) 5th Annual Meeting Tony B. Academic Travel Award 2017 Society for Laboratory Automation and Screening (SLAS) 6th Annual Meeting Tony B. Academic Travel Award 2021 American Heart Association (AHA) Postdoctoral Fellowship 2022 American Heart Association (AHA) Young Scientist Travel Award

University/Lab Affiliation and Title

Southern University of Science and Technology

Faculty

Medical School

Academic Background & Achievements

2008-2012 Bachelor in Pharmaceutical Engineering: Guizhou University
2012-2017 PhD in Cardiovascular Pharmacology: Fudan University
Published over ten research papers as first author in the field of cardiology

Work Experience

2017-2022 Postdoctoral Researcher at University of California, Davis
2022-present Associate Professor at Southern University of Science and Technology

Awards

2012 Guizhou Province Outstanding Graduate
2012 Fudan University PhD Freshman Scholarship
2013 Fudan University Cross-disciplinary Excellent PhD Student Research Award
2014 9th PharmSci@Asia Forum, Paper Award
2015 Shanghai Pharmacological Society Young Scholar Forum, Excellent Paper Award
2015 Yangtze Delta Region Forum on Life Sciences and Human Health, First Prize
2016 Society for Laboratory Automation and Screening (SLAS) 5th Annual Meeting Tony B. Academic Travel Award
2017 Society for Laboratory Automation and Screening (SLAS) 6th Annual Meeting Tony B. Academic Travel Award
2021 American Heart Association (AHA) Postdoctoral Fellowship
2022 American Heart Association (AHA) Young Scientist Travel Award

Areas of Focus	GPCR nanodomain regulation of cardiac physiology and pathology Calcium signaling disorders in heart failure and arrhythmias Polypharmacology in cardiovascular pharmacology
Publications	Nuclear β-adrenergic signaling microdomain alleviates diabetic kidney fibrosis by YAP inactivation, Xiang W, Lu H, Shen A, Ni H, Wang Y Nitric oxide synthase isoforms dictate a biased and compartmentalized adrenergic signaling to promote cardiac contractility, Wang Y, Zhao M, Liu XH, Xu B, Rivera G, Xiang YK Phosphodiesterases in heart and vessels- From Physiology to Diseases, Fu Q, Wang Y, Yan C, Xiang YK, 2023 HFrEF and HFpEF model-specific remodeling of subcellular PKA signaling at the ryanodine receptors and SERCA2a, Bing Xu, Ying Wang, Chaoqun Zhu, Meimi Zhao, Yu Zhang, Bingqing Deng, Zhenduo Zhu; Qiuyun Guan, Nipavan Chiamvimonvat, Qingtong Wang, and Yang K. Xiang Unveiling Catecholamine Dynamics in Cardiac Health and Disease: Mechanisms, Implications, and Future Perspectives, Wenjing Xiang1, Xingyun Wang1, Lei Li1, Junhui Zeng1, Haocheng Lu1&, Ying Wang1&, 2023 βIV-Spectrin in Cardiac Fibroblasts: Implications for Fibrosis and Therapeutic Targeting in Cardiac Diseases, Xiang W, Zhou N, Li L, Chen F, Li L, Wang Y, 2023 Divergent Actions of Myofibroblast and Myocyte β2-Adrenoceptor in Heart Failure and Fibrotic Remodeling, Deng B, Zhang Y, Zhu C, Wang Y, Weatherford E, Xu B, Liu X, Conway SJ, Abel ED, Xiang YK, 2023 Monoamine oxidase A and organic cation transporter 3 coordinate intracellular β1AR signaling to calibrate cardiac contractile function, Wang Y, Zhao M, Xu B, Bahriz SMF, Zhu C, Jovanovic A, Ni H, Jacobi A, Kaludercic N, Di Lisa F, Hell JW, Shih JC, Paolocci N, Xiang YK, 2022 Monoamine Oxidases Desensitize Intracellular β1AR Signaling in Heart Failure, Wang Y, Zhao M, Shi Q, Xu B, Zhu C, Li M, Mir V, Bers DM, Xiang YK, 2022 Intracellular β1-Adrenergic receptors and Organic Cation Transporter 3 Mediate Phospholamban Phosphorylation to Enhance Cardiac Contractility, Wang Y, Shi Q, Li M, Zhao M, Reddy GR, Teoh JP, Xu B, Zhu CQ, Ireton KE, Srinivasan S, Chen SL, Gasser PJ, Bossuyt J, Hell JW, Bers DM, Xiang YK, 2020 Carvedilol induces biased β1 adrenergic receptor-Nitric oxide synthase 3-cyclic guanylyl monophosphate signaling to promote cardiac contractility, Wang Q, Wang Y, West TM, Liu Y, Reddy GR, Barbagallo F, Xu B, Shi Q, Deng B, Wei W, Xiang YK, 2020 GRK5 Controls SAP97-Dependent Cardiotoxic β1 adrenergic receptor-CaMKII signaling in heart failure, Xu B, Li M, Wang Y, Zhao M, Morotti S, Shi Q, Wang Q, Barbagallo F, Teoh JP, Reddy GR, Bayne EF, Liu Y, Shen A, Puglisi JL, Ge Y, Li J, Grandi E, Nieves-Cintron M, Xiang YK, 2020 Illuminating cell signaling with genetically encoded FRET biosensors in adult mouse cardiomyocytes, Reddy GR, West TM, Jian Z, Jaradeh M, Shi Q, Wang Y, Chen-Izu Y, Xiang YK, 2018 The discovery of a novel inhibitor of apoptotic protease activating factor-1 (Apaf-1) for ischemic heart: synthesis, activity and target identification, Wang Y, Cao Y, Zhu Q, Gu X, Zhu YZ, 2016 ZYZ-772 Prevents Cardiomyocyte Injury by Suppressing nox4-derived ROS production and apoptosis, Wang Y, Zhong L, Liu X, Zhu YZ, 2017 Apoptotic Protease activating factor-1 inhibitor mitigates myocardial ischemia injury via disturbing procaspase-9 recruitment by Apaf-1, Wang Y, Zhang Q, Zhong L, Lin M, Luo X, Liu S, Xu P, Liu X, Zhu YZ, 2017 Neuroprotective Effect of SCM-198 through stabilizing endothelial cell function, Zhang QY, Wang ZJ, Miao L, Wang Y, Chang LL, Guo W, Zhu YZ, 2019 Novel Therapeutic effects of leonurine on ischemic stroke: New Mechanisms of BBB Integrity, Zhang QY, Wang ZJ, Sun DM, Wang Y, Xu P, Wu WJ, Liu XH, Zhu YZ, 2017 Probing spatiotemporal PKA activity at the ryanodine receptor and SERCA2a nanodomains in cardomyocytes, Xu B, Wang Y, Bahriz SMFM, Zhao M, Zhu C, Xiang YK, 2022

Areas of Focus

GPCR nanodomain regulation of cardiac physiology and pathology
Calcium signaling disorders in heart failure and arrhythmias
Polypharmacology in cardiovascular pharmacology

Publications

Nuclear β-adrenergic signaling microdomain alleviates diabetic kidney fibrosis by YAP inactivation, Xiang W, Lu H, Shen A, Ni H, Wang Y
Nitric oxide synthase isoforms dictate a biased and compartmentalized adrenergic signaling to promote cardiac contractility, Wang Y, Zhao M, Liu XH, Xu B, Rivera G, Xiang YK
Phosphodiesterases in heart and vessels- From Physiology to Diseases, Fu Q, Wang Y, Yan C, Xiang YK, 2023
HFrEF and HFpEF model-specific remodeling of subcellular PKA signaling at the ryanodine receptors and SERCA2a, Bing Xu, Ying Wang, Chaoqun Zhu, Meimi Zhao, Yu Zhang, Bingqing Deng, Zhenduo Zhu; Qiuyun Guan, Nipavan Chiamvimonvat, Qingtong Wang, and Yang K. Xiang
Unveiling Catecholamine Dynamics in Cardiac Health and Disease: Mechanisms, Implications, and Future Perspectives, Wenjing Xiang1*, Xingyun Wang1*, Lei Li1, Junhui Zeng1, Haocheng Lu1&, Ying Wang1&, 2023
βIV-Spectrin in Cardiac Fibroblasts: Implications for Fibrosis and Therapeutic Targeting in Cardiac Diseases, Xiang W, Zhou N, Li L, Chen F, Li L, Wang Y, 2023
Divergent Actions of Myofibroblast and Myocyte β2-Adrenoceptor in Heart Failure and Fibrotic Remodeling, Deng B, Zhang Y, Zhu C, Wang Y, Weatherford E, Xu B, Liu X, Conway SJ, Abel ED, Xiang YK, 2023
Monoamine oxidase A and organic cation transporter 3 coordinate intracellular β1AR signaling to calibrate cardiac contractile function, Wang Y, Zhao M, Xu B, Bahriz SMF, Zhu C, Jovanovic A, Ni H, Jacobi A, Kaludercic N, Di Lisa F, Hell JW, Shih JC, Paolocci N, Xiang YK, 2022
Monoamine Oxidases Desensitize Intracellular β1AR Signaling in Heart Failure, Wang Y, Zhao M, Shi Q, Xu B, Zhu C, Li M, Mir V, Bers DM, Xiang YK, 2022
Intracellular β1-Adrenergic receptors and Organic Cation Transporter 3 Mediate Phospholamban Phosphorylation to Enhance Cardiac Contractility, Wang Y*, Shi Q*, Li M, Zhao M, Reddy GR, Teoh JP, Xu B, Zhu CQ, Ireton KE, Srinivasan S, Chen SL, Gasser PJ, Bossuyt J, Hell JW, Bers DM, Xiang YK, 2020
Carvedilol induces biased β1 adrenergic receptor-Nitric oxide synthase 3-cyclic guanylyl monophosphate signaling to promote cardiac contractility, Wang Q, Wang Y, West TM, Liu Y, Reddy GR, Barbagallo F, Xu B, Shi Q, Deng B, Wei W, Xiang YK, 2020
GRK5 Controls SAP97-Dependent Cardiotoxic β1 adrenergic receptor-CaMKII signaling in heart failure, Xu B, Li M, Wang Y, Zhao M, Morotti S, Shi Q, Wang Q, Barbagallo F, Teoh JP, Reddy GR, Bayne EF, Liu Y, Shen A, Puglisi JL, Ge Y, Li J, Grandi E, Nieves-Cintron M, Xiang YK, 2020
Illuminating cell signaling with genetically encoded FRET biosensors in adult mouse cardiomyocytes, Reddy GR, West TM, Jian Z, Jaradeh M, Shi Q, Wang Y, Chen-Izu Y, Xiang YK, 2018
The discovery of a novel inhibitor of apoptotic protease activating factor-1 (Apaf-1) for ischemic heart: synthesis, activity and target identification, Wang Y, Cao Y, Zhu Q, Gu X, Zhu YZ, 2016
ZYZ-772 Prevents Cardiomyocyte Injury by Suppressing nox4-derived ROS production and apoptosis, Wang Y, Zhong L, Liu X, Zhu YZ, 2017
Apoptotic Protease activating factor-1 inhibitor mitigates myocardial ischemia injury via disturbing procaspase-9 recruitment by Apaf-1, Wang Y, Zhang Q, Zhong L, Lin M, Luo X, Liu S, Xu P, Liu X, Zhu YZ, 2017
Neuroprotective Effect of SCM-198 through stabilizing endothelial cell function, Zhang QY, Wang ZJ, Miao L, Wang Y, Chang LL, Guo W, Zhu YZ, 2019
Novel Therapeutic effects of leonurine on ischemic stroke: New Mechanisms of BBB Integrity, Zhang QY, Wang ZJ, Sun DM, Wang Y, Xu P, Wu WJ, Liu XH, Zhu YZ, 2017
Probing spatiotemporal PKA activity at the ryanodine receptor and SERCA2a nanodomains in cardomyocytes, Xu B, Wang Y, Bahriz SMFM, Zhao M, Zhu C, Xiang YK, 2022

Gpcr Nanodomain Cardiac Physiology Pathology Calcium Signaling Heart Failure Arrhythmias Polypharmacology

Chao Shengping - Wuhan University

Ming Chen - Wuhan University

Yanhong Tang - Wuhan University

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