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Xu Yang
Medical School
Southern University of Science and Technology
Guangdong
Language: English, Chinese
Car-T Cells
Solid Tumors
Tumor Microenvironment
Molecular Mechanisms
Cell Infiltration
Cell Exhaustion
Metabolic Optimization
Immunotherapy
Cancer Treatment
Cellular Engineering
Areas of Focus
- Application of CAR-T cells in solid tumors
- Molecular cellular mechanisms in the tumor microenvironment
- Improving CAR-T cell infiltration in solid tumors
- Molecular mechanisms of CAR-T cell exhaustion
- Optimizing CAR-T cell metabolism in tumor environments
Work Experience
- 2015 – 2020 University of North Carolina at Chapel Hill - Postdoctoral Researcher
Academic Background & Achievements
- 2006 – 2010 Bachelor: University of Toronto, Immunology
- 2010 – 2015 PhD: Baylor College of Medicine, Immunology
- Published 8 papers with a total citation of 575 times and obtained two US patents.
Publications
- Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15., Xu Y, et al., 2014
- Glycolysis determines dichotomous regulation of T cell subsets in hypoxia., Xu Y, et al., 2016
- Selection bias: maintaining less-differentiated T cells for adoptive immunotherapy., Xu Y, et al., 2016
- Interleukin-23 engineering improves CAR-T cell function in solid tumors., Ma X, et al., 2020
- Themis-SHP1 Recruitment by 4-1BB Tunes LCK-Mediated Priming of Chimeric Antigen Receptor-Redirected T cells., Sun C, et al., 2020
- Antitumor Responses in the Absence of Toxicity in Solid Tumors by Targeting B7-H3 Via Chimeric Antigen Receptor T Cells., Du H, et al., 2019
- HERV-K-specific T cells eliminate diverse HIV-1/2 and SIV primary isolates., Jones RB, et al., 2012
- LINE-1 retrotransposable element DNA accumulates in HIV-1-infected cells., Jones RB, et al., 2013
Awards
- 2016: Horizon Fellowship Award, Department of Defense, USA
