Professor | Xu Yang | Asia Growth Partners

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Name	Xu Yang
Contact Information	xuy6@sustech.edu.cn
Language ability	English, Chinese
Province	Guangdong

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Name

Xu Yang

Contact Information

xuy6@sustech.edu.cn

Language ability

English, Chinese

Province

Guangdong

University/Lab Affiliation and Title	Southern University of Science and Technology
Faculty	Medical School
Academic Background & Achievements	2006 – 2010 Bachelor: University of Toronto, Immunology 2010 – 2015 PhD: Baylor College of Medicine, Immunology Published 8 papers with a total citation of 575 times and obtained two US patents.
Work Experience	2015 – 2020 University of North Carolina at Chapel Hill - Postdoctoral Researcher
Awards	2016: Horizon Fellowship Award, Department of Defense, USA

University/Lab Affiliation and Title

Southern University of Science and Technology

Faculty

Medical School

Academic Background & Achievements

2006 – 2010 Bachelor: University of Toronto, Immunology
2010 – 2015 PhD: Baylor College of Medicine, Immunology
Published 8 papers with a total citation of 575 times and obtained two US patents.

Work Experience

2015 – 2020 University of North Carolina at Chapel Hill - Postdoctoral Researcher

Awards

2016: Horizon Fellowship Award, Department of Defense, USA

Areas of Focus	Application of CAR-T cells in solid tumors Molecular cellular mechanisms in the tumor microenvironment Improving CAR-T cell infiltration in solid tumors Molecular mechanisms of CAR-T cell exhaustion Optimizing CAR-T cell metabolism in tumor environments
Publications	Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15., Xu Y, et al., 2014 Glycolysis determines dichotomous regulation of T cell subsets in hypoxia., Xu Y, et al., 2016 Selection bias: maintaining less-differentiated T cells for adoptive immunotherapy., Xu Y, et al., 2016 Interleukin-23 engineering improves CAR-T cell function in solid tumors., Ma X, et al., 2020 Themis-SHP1 Recruitment by 4-1BB Tunes LCK-Mediated Priming of Chimeric Antigen Receptor-Redirected T cells., Sun C, et al., 2020 Antitumor Responses in the Absence of Toxicity in Solid Tumors by Targeting B7-H3 Via Chimeric Antigen Receptor T Cells., Du H, et al., 2019 HERV-K-specific T cells eliminate diverse HIV-1/2 and SIV primary isolates., Jones RB, et al., 2012 LINE-1 retrotransposable element DNA accumulates in HIV-1-infected cells., Jones RB, et al., 2013

Areas of Focus

Application of CAR-T cells in solid tumors
Molecular cellular mechanisms in the tumor microenvironment
Improving CAR-T cell infiltration in solid tumors
Molecular mechanisms of CAR-T cell exhaustion
Optimizing CAR-T cell metabolism in tumor environments

Publications

Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15., Xu Y, et al., 2014
Glycolysis determines dichotomous regulation of T cell subsets in hypoxia., Xu Y, et al., 2016
Selection bias: maintaining less-differentiated T cells for adoptive immunotherapy., Xu Y, et al., 2016
Interleukin-23 engineering improves CAR-T cell function in solid tumors., Ma X, et al., 2020
Themis-SHP1 Recruitment by 4-1BB Tunes LCK-Mediated Priming of Chimeric Antigen Receptor-Redirected T cells., Sun C, et al., 2020
Antitumor Responses in the Absence of Toxicity in Solid Tumors by Targeting B7-H3 Via Chimeric Antigen Receptor T Cells., Du H, et al., 2019
HERV-K-specific T cells eliminate diverse HIV-1/2 and SIV primary isolates., Jones RB, et al., 2012
LINE-1 retrotransposable element DNA accumulates in HIV-1-infected cells., Jones RB, et al., 2013

Car-T Cells Solid Tumors Tumor Microenvironment Molecular Mechanisms Cell Infiltration Cell Exhaustion Metabolic Optimization Immunotherapy Cancer Treatment Cellular Engineering

Hua-Wen Sun - Wuhan University

Xin Chen - Wuhan University

Na Li - Wuhan University

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