2010-09 - 2014-07: Bachelor's Degree from Shandong University
2014-09 - 2019-07: PhD from Tsinghua University
2019-07 - 2021-11: Postdoctoral Researcher at Westlake University
2021-11 - Present: Assistant Professor at Southern University of Science and Technology
2023-06: Outstanding Communist Party Member at Southern University of Science and Technology
2021-12: Outstanding Postdoctoral Innovator in National Postdoctoral Entrepreneurship Competition
2021-06: First Prize in Zhejiang Natural Science Award (Second Contributor)
2021-06: Outstanding Communist Party Member in Zhejiang Province Educational Institutions
2021-04: Recognition for Major Medical Advances in China 2020 (COVID-19 Prevention and Treatment)
2020-12: MIT Technology Review's Innovators Under 35 China
2020-12: Top Ten Innovations in National 'Postdoctoral Innovation Plan'
2020-11: Second Prize in the 68th Batch of China Postdoctoral Science Foundation Grant
2020-06: China Postdoctoral Science Foundation's Innovative Talent Support Plan 2020
2020-06: Outstanding Communist Party Member in Hangzhou Education System 2019
2020-01: Major Medical Advances in China 2019 (Pharmacy)
Research
Structural and functional studies of membrane proteins related to major human diseases, including the molecular mechanisms of SARS-CoV-2 host cell invasion, human amino acid transport proteins, and cholesterol metabolism regulatory complexes.
The cryo-EM structure of homotetrameric attachment glycoprotein from langya henipavirus, Yingying Guo*, Songyue Wu*, Wenting Li*, Haonan Yang*, Tianhao Shi, Bin Ju†, Zheng Zhang†, Renhong Yan†, 2024
Structural insight into the assembly and working mechanism of helicase-primase D5 from Mpox Virus, Yaning Li*, Jing Zhu*, Yingying Guo†, Renhong Yan†, 2024
Cryo-EM structures of SARS-CoV-2 BA.2-derived subvariants spike in complex with ACE2 recepter, Yaning Li*, Chang Ren*, Yaping Shen*, Yuanyuan Zhang*, Jin Chen, Jiangnan Zheng, Rujun Tian, Liwei Cao†, Renhong Yan†, 2023
Structural insight into the substrate recognition and transport mechanism of amino acid transporter complex ACE2-B0AT1 and ACE2-SIT1, Yaning Li*, Yiming Chen*, Yuanyuan Zhang*, Yaping Shen*, Kangtai Xu, Yaqi Liu, ZilongWang†, Renhong Yan†, 2023
Structural Basis for the Enhanced Infectivity and Immune Evasion of Omicron Subvariants, Yaning Li*, Yaping Shen*, Yuanyuan Zhang*, Renhong Yan†, 2023
Structural basis for the assembly of the DNA polymerase holoenzyme from a monkeypox virus variant, Renhong Yan*†, Yaning Li*, Yaping Shen*, Ziwei Hu*, 2023
Structures of ACE2–SIT1 recognized by Omicron variants of SARS-CoV-2, Yaping Shen*, Jianhui Wang*, Yaning Li*, Yuanyuan Zhang*, Ruilin Tian†, Renhong Yan†, 2022
Structural and functional analysis of an inter-Spike bivalent neutralizing antibody against SARS-CoV-2 variants, Yaning Li*, Qing Fan*, Bing Zhou*, Yaping Shen*, Yuanyuan Zhang*, Lin Cheng*, Furong Qi*, Shuo Song*, Yingying Guo*, Renhong Yan†, Bin Ju†, Zheng Zhang†, 2022
ACE2, B(0)AT1, and SARS-CoV-2 spike protein: Structural and functional implications, Yuanyuan Zhang*, Renhong Yan†, Qiang Zhou†, 2022
Cryo-EM structures of recombinant human sodium-potassium pump determined in three different states, Yingying Guo*, Yuanyuan Zhang*, Renhong Yan*, Bangdong Huang, Fangfei Ye, Liushu Wu, Ximin Chi, Yi Shi, Qiang Zhou†, 2022
Cryo-EM structures of the human sodium-potassium pump revealing the gating mechanism on the cytopiasmic side, Yingying Guo*, Yuanyuan Zhang*, Renhong Yan*, Bangdong Huang, Fangfei Ye, Liushu Wu, Ximin Chi, Qiang Zhou†, 2021
Structural basis for sterol sensing by Scap and Insig, Renhong Yan*†, Pingping Cao*, Wenqi Song*, Yaning Li*, Tongtong Wang, Hongwu Qian, Chuangye Yan†, Nieng Yan†, 2021
A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols, Renhong Yan*, Pingping Cao*, Wenqi Song*, Hongwu Qian, Ximing Du, Hudson W. Coates, Xin Zhao, Yaning Li, Shuai Gao, Xin Gong, Ximing Liu, Jianhua Sui, Jianlin Lei, Hongyuan Yang, Andrew J. Brown, Qiang Zhou, Chuangye Yan, Nieng Yan, 2021
Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter, Renhong Yan*, Yaning Li*, Jennifer Müller*, Yuanyuan Zhang*, Simon Singer, Lu Xia, Xinyue Zhong, Jürg Gertsch, Karl-Heinz Altmann, Qiang Zhou, 2021
Engineered trimeric ACE2 binds viral spike protein and locks it in 'Three-up' conformation to potently inhibit SARS-CoV-2 infection, Liang Guo*, Wenwen Bi*, Xinling Wang*, Wei Xu*, Renhong Yan*, Yuanyuan Zhang*, Kai Zhao, Yaning Li, Mingfeng Zhang, Xia Cai, Shibo Jiang, Youhua Xie, Qiang Zhou, Lu Lu, Bobo Dang, 2021
Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies, Renhong Yan*, Ruoke Wang*, Bin Ju*, Jinfang Yu*, Yuanyuan Zhang*, Nan Liu*, Jia Wang, Qi Zhang, Peng Chen, Bing Zhou, Yaning Li, Yaping Shen, Shuyuan Zhang, Long Tian, Yingying Guo, Lu Xia, Xinyue Zhong, Lin Cheng, Xiangyang Ge, Juanjuan Zhao, Hong-Wei Wang, Xinquan Wang, Zheng Zhang†, Linqi Zhang†, and Qiang Zhou†, 2021
Structural basis for the different states of the spike protein of SARS-CoV-2 in complex with ACE2, Renhong Yan*†, Yuanyuan Zhang*, Yaning Li*, Fangfei Ye, Yingying Guo, Lu Xia, Xinyue Zhong, Ximin Chi, and Qiang Zhou†, 2021
Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2, Renhong Yan, Yuanyuan Zhang, Yaning Li, Lu Xia, Yingying Guo, Qiang Zhou, 2020
A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2, Xiangyang Chi*, Renhong Yan*, Jun Zhang*, Guanying Zhang, Yuanyuan Zhang, Meng Hao, Zhe Zhang, Pengfei Fan, Yunzhu Dong, Yilong Yang, Zhengshan Chen, Yingying Guo, Jinlong Zhang, Yaning Li, Xiaohong Song, Yi Chen, Lu Xia, Ling Fu, Lihua Hou, Junjie Xu, Changming Yu, Jianmin Li, Qiang Zhou, Wei Chen, 2020
Cryo-EM structure of the human heteromeric amino acid transporter b0,+AT-rBAT, Renhong Yan*, Yaning Li*, Yi Shi*, Jiayao Zhou, Jianlin Lei, Jing Huang, Qiang Zhou, 2020
Structural basis for catalysis and substrate specificity of human ACAT1, Hongwu Qian*, Xin Zhao*, Renhong Yan*, Xia
