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Xin Gong
Life Science
Southern University of Science and Technology
Guangdong
Language: Chinese, English
Structural Biology
Biochemistry
Biophysics
Cholesterol Metabolism
Lipid Metabolism
Disease-Related Pathways
Protein Structure
Protein Function
Metabolic Regulation
Disease Mechanisms
Areas of Focus
- Structural biology research methods, biochemistry, and biophysics to study proteins involved in cholesterol and lipid metabolism regulation pathways related to major diseases
Work Experience
- 2019-present Southern University of Science and Technology, Department of Biology, Associate Professor
- 2017-2018 Princeton University, Department of Molecular Biology, Postdoctoral Researcher
- 2015-2017 Tsinghua University, School of Medicine, Postdoctoral Researcher
Academic Background & Achievements
- 2010-2015 PhD: Tsinghua University, School of Life Sciences
- 2006-2010 Bachelor: Huazhong University of Science and Technology, School of Life Science and Technology
- Published as first author or corresponding author in top international journals such as Cell and Science
Publications
- Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm, Qian H*, Cao P*, Hu M, Gao S, Yan N#, Gong X#, 2019
- Structural basis for the recognition of Sonic Hedgehog by human Patched1, Gong X*, Qian H*, Cao P*, Zhao X, Zhou Q, Lei J, Yan N#, 2018
- Structure of the human lipid exporter ABCA1, Qian H*, Zhao X, Cao P, Lei J, Yan N#, and Gong X*, 2017
- Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization, Gong X*, Qian H*, Shao W*, Li J, Wu J, Liu J, Li W, Wang H, Espenshade P#, Yan N#, 2016
- Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection, Gong X*, Qian H*, Zhou X*, Wu J*, Wan T*, Cao P, Huang W, Zhao X, Wang X, Wang P, Shi Y, Gao GF, Zhou Q#, Yan N#, 2016
- Structure of the WD40 domain of SCAP from fission yeast reveals the molecular basis for SREBP recognition, Gong X*, Li J*, Shao W*, Wu J, Qian H, Ren R, Espenshade P#, Yan N#, 2015
Awards
- 2019 Guangdong Province 'Outstanding Young Scientist Fund'
- 2019 Shenzhen High-level Talent (National Leading Talent)
- 2019 Shenzhen Overseas High-level Talent (Category B)
