Upload Avatar (500 x 500)
Xiaochen Wang
Life Science
Southern University of Science and Technology
Guangdong
Language: Chinese, English
Lysosomes
C. Elegans
Cell Degradation
Apoptotic Cell Clearance
Genetics
Cell Biology
Biochemistry
Nanoparticles
Physiological Functions
Pathological Functions
Areas of Focus
- Lysosomal research using C. elegans
- Cell degradation processes mediated by lysosomes
Work Experience
- 2023.07 - Present - Southern University of Science and Technology - Chair Professor
- 2016.05 - 2023.06 - Institute of Biophysics, Chinese Academy of Sciences - Researcher
- 2011.07 - 2016.04 - Beijing Institute of Life Sciences - Senior Researcher
- 2006.05 - 2011.07 - Beijing Institute of Life Sciences - Researcher
- 1999.09 - 2006.04 - University of Colorado - Postdoctoral Researcher
Academic Background & Achievements
- 1994-1999 PhD: Peking University
- Howard Hughes Medical Institute (HHMI) International Young Scientist Award
- Selected for the National Thousand Talents Program
Publications
- Lysosomal chloride transporter CLH-6 protects lysosome membrane integrity via cathepsin activation, Zhang Q, Li Y, Jian Y, Li M, Wang X, 2023
- Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C.elegans, Sun Y, Li M, Zhao D, Li X, Yang C, Wang X, 2020
- An ECM-to-Nucleus Signaling Pathway Activates Lysosomes for C. elegans Larval development, Miao R, Li M, Zhang Q, Yang C, Wang X, 2020
- Autophagy-dependent ribosomal RNA degradation is essential for maintaining nucleotide homeostasis during C. elegans development, Liu Y, Zou W, Yang P, Wang L, Ma Y, Zhang H, Wang X, 2018
- GOP-1 promotes apoptotic cell degradation by activating the small GTPase Rab2 in C. elegans, Yin J, Huang Y, Guo P, Hu S, Yoshina S, Xuan N, Gan Q, Mitani S, Yang C, Wang X, 2017
- The lysosomal membrane protein SCAV-3 maintains lysosome integrity and adult longevity, Li Y, Chen B, Zou W, Wang X, Wu Y, Zhao D, Sun Y, Liu Y, Chen L, Miao L, Yang C, Wang X, 2016
- PtdIns(4,5)P2 and PtdIns3P coordinate to regulate phagosomal sealing for apoptotic cell clearance, Cheng S, Wang K, Zou W, Miao R, Huang Y, Wang H, Wang X, 2015
- C. elegans secreted lipid-binding protein NRF-5 mediates PS appearance on phagocytes for cell corpse engulfment, Zhang Y, Wang H, Kage-Nakadai E, Mitani S, Wang X, 2012
- LAAT-1 is the lysosomal lysine/arginine transporter that maintains amino acid homeostasis, Liu B, Du H, Rutkowski R, Gartner A, Wang X, 2012
- Sequential action of Caenorhabditis elegans Rab GTPases regulates phagolysosome formation during apoptotic cell degradation, Guo P, Hu T, Zhang J, Jiang S, Wang X, 2010
- Caenorhabditis elegans transthyretin-like protein TTR-52 mediates recognition of apoptotic cells by the CED-1 phagocyte receptor, Wang X, Li W, Zhao D, Liu B, Shi Y, Chen B, Yang H, Guo P, Geng X, Shang Z, Peden E, Kage-Nakadai E, Mitani S, Xue D, 2010
Awards
- 2019: Selected for the State Council Special Allowance
- 2015: Selected for the Ministry of Science and Technology Innovation Talent Promotion Plan
- 2014: National Thousand Talents Program
- 2013: Tenth China Young Women Scientist Award
- 2013: National Outstanding Young Scientist Fund
- 2012: Howard Hughes Medical Institute (HHMI) International Young Scientist Award
- 2012: WuXi AppTec Life Science and Chemistry Research Award Scholar
