1991-1993: PhD in Immunology, Beijing Medical University
1986-1989: Master's in Immunology, West China University of Medical Sciences
1979-1984: Bachelor's in Clinical Medicine, West China University of Medical Sciences
2017-present: Lifetime Professor, Southern University of Science and Technology
2005-2018: Professor, Sichuan University; Director, Neurodevelopment and Metabolism Research Lab, West China Hospital
2000-2005: Research Faculty, Department of Neuroscience, Johns Hopkins University
1997-2000: Postdoctoral Researcher, Department of Neuroscience, Johns Hopkins University
1993-1997: Postdoctoral Researcher, University of Toronto
2019: Shenzhen National-Level Leading Talent in Science and Technology
2008-2014: Chief Scientist, National Science and Technology Ministry '973' Project
2008: Sichuan Province Outstanding Foreign Teacher
Research
Neuronal-glial cell functional regulation in health and disease Molecular regulation of oligodendrocytes and myelin development Microglia and neurodegenerative disease/regeneration Neuronal metabolism and oxidative stress in neurodegenerative disease
Rheb1 controls mitochondrial energy metabolism by activating pyruvate dehydrogenase independently of mTORC1, Yang W, Pang D, Du C, Jiang W, Luo L, Yu Z, Tang P, Xia X, Cui Y, Chen C, Liu Y, Wei Y-Q, Worley P.F, Xiao B*, 2019
LanCL1 Promotes Motor Neuron Survival and Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice, Tan H, Chen M, Xia X, Pang D, Du C, Yang W, Cui Y, Huang C, Jiang W, Li C, Shang H, Worley PF, Xiao B*, 2019
Targeting human Mas-related G protein-coupled receptor X1 to inhibit persistent pain, Li Z, Tseng PY, Tiwari V, Xu Q, He SQ, Wang Y, Zheng Q, Han L, Wu Z Blobaum AL, Cui Y, Tiwari V, Sun S, Cheng Y, Huang-Lionnet JH, Geng Y, Xiao B, Peng J, Hopkins C, Raja SN, Guan Y, Dong X, 2017
Orai1-Mediated Antimicrobial Secretion from Pancreatic Acini Shapes the Gut Microbiome and Regulates Gut Innate Immunity, Ahuja M, Schwartz DM, Tandon M, Son A, Zeng M, Swaim W, Eckhaus M, Hoffman V, Cui Y, Xiao B, Worley PF, Muallem S, 2017
Rheb1 mediates DISC1-dependent regulation of new neuron development in the adult hippocampus, Eunchai Kang, Ju Young Kim, Cindy Y Liu, Bo Xiao, Po Yu Chen, Kimberly M Christian, Paul F Worley, Hongjun Song, Guo-li Ming, 2015
Oligodendrocyte precursor cell-intrinsic effect of Rheb1 controls differentiation and mediates mTORC1-dependent myelination in brain, Zou Y, Jiang W, Zhang J, Bu J, Wang J, Zou J, Zhou L, Yu S, Yang W, Luo L, Lu QR, Liu Y, Chen M, Worley PF, Xiao B*, 2014
Developmental and activity-dependent expression of LanCL1 confers antioxidant activity required for neuronal survival, Huang C, Chen M, Pang D, Bi D, Zou Y, Xia X, Yang W, Luo L, Deng R, Tan H, Zhou L, Yu S, Guo L, Du X, Cui Y, Hu J, Mao Q, Worley PF, Xiao B*, 2014
Rheb1 is Required for mTORC1 and Myelination in Postnatal Brain Development, Zou J, Zhou L, Du XX, Ji Y, Xu J, Tian J, Jiang W, Zou Y, Yu S, Gan L, Luo M, Yang Q, Cui Y, Yang W, Xia X, Chen M, Zhao X, Shen Y, Chen PU, Worley PF, Bo Xiao*, 2011
A subpopulation of nociceptors specifically linked to itch, Han L, Ma C, Liu Q, Weng HJ, Cui Y, Tang Z, Kim Y, Nie H, Qu L, Patel KN, Li Z, McNeil B, He S, Guan Y, Xiao B, Lamotte RH, Dong X, 2013
Cardiac ablation of Rheb1 induces impaired heart growth, endoplasmic reticulum-associated apoptosis and heart failure in infant mice, Cao Y, Tao L, Shen S, Xiao J, Wu H, Li B, Wu X, Luo W, Xiao Q, Hu X, Liu H, Nie J, Lu S, Yuan B, Han Z, Xiao B, Yang Z, Li X, 2013
A prolyl-isomerase mediates dopamine-dependent plasticity and cocaine motor sensitization, Park JM, Hu JH, Milshteyn A, Zhang PW, Moore CG, Park S, Datko MC, Domingo RD, Reyes CM, Wang XJ, Etzkorn FA, Xiao B, Szumlinski KK, Kern D, Linden DJ, Worley PF, 2013
Loss of Predominant Shank3 Isoforms Results in Hippocampus-Dependent Impairments in Behavior and Synaptic Transmission, Kouser M, Speed HE, Dewey CM, Reimers JM, Widman AJ, Gupta N, Liu S, Jaramillo TC, Bangash M, Xiao B, Worley PF, and Powell CM, 2013
Homers at the Interface between Reward and Pain, Obara I, Goulding SP, Gould AT, Lominac KD, Hu JH, Zhang PW, von Jonquieres G, Dehoff M, Xiao B, Seeburg PH, Worley PF, Klugmann M, Szumlinski KK, 2013
Preso1 dynamically regulates group I Metabotropic glutamate receptors, Hu JH, Yang L, Kammermeier PJ, Moore CG, Brakeman PR, Tu J, Yu S, Petralia RS, Li Z, Zhang PW, Park JM, Dong X, Xiao B, Worley PF, 2012
The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2, Delgoffe GM, Pollizzi KN, Waickman AT, Heikamp E, Meyers DJ, Horton MR, Xiao B, Worley PF, Powell JD, 2011
SRF binding to SRE 6.9 in the Arc promoter is essential for the late phase of LTD in cultured cerebellar Purkinje cells, Smith-Hicks C, Xiao B, Deng R, Ji Y, Zhao X, Shepherd JD, Posern G, Kuhl D, Huganir RL, Ginty DD, Worley PF, Linden DJ, 2010
Homeostatic Scaling requires Group I mGluR activation mediated by Homer1a Neuron, Hu JH, Park JM, Park S, Xiao B, Dehoff MD, Kim S, Hayashi T, Schwarz M, Huganir RL, Seeburg PH, Linden DJ, Worley PF, 2010
The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment, Delgoffe GM, Kole TP, Zheng Y, Zarek PE, Matthews KL, Xiao B, Worley PF, Kozma SC, Powell JD, 2009
Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer, Ango F, Prezeau L, Muller T, Tu JC, Xiao B, Worley PF, Pin JP, Bockaert J, Fagni L, 2001
Homer: a link between neural activity and glutamate receptor function (invited), Xiao B, Tu JC, Worley PF, 2000
Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins, Xiao B, Tu JC, Petralia RS, Yuan JP, Doan A, Breder CD, Lanahan AA, Wenthold RJ, Worley PF, 1998
Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins, Tu JC, Xiao B (co-first author), Naisbitt S, Yuan JP, Petralia RS, Brakeman P, Doan A, Lanahan AA, Sheng M, Worley PF, 1999
Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors, Tu JC, Xiao B (co-first author), Yuan JP, Lanahan AA, Leoffert K, Li M, Linden DJ, Worley PF, 1998
Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition, Beneken J, Tu JC, Xiao B, Yuan JP, Worley PF, Leahy DJ, 2000
