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Zhang Li
Life Science
Southern University of Science and Technology
Guangdong
Language: Chinese, English
Mycobacterium Tuberculosis
Host Interaction
Macrophage Death
Infection Mechanisms
Type I Interferon
Tuberculosis
Host-Directed Therapies
Pulmonary Tuberculosis
Immune Response
Pathogen-Host Dynamics
Areas of Focus
- Mycobacterium tuberculosis and host interaction
- Macrophage death mechanisms induced by Mycobacterium tuberculosis infection
- Role of Type I interferon in tuberculosis
- Host-directed therapies for pulmonary tuberculosis
Work Experience
- July 2013 - April 2015: Postdoctoral Researcher, Beijing Institute of Life Sciences
- April 2015 - February 2021: Postdoctoral Researcher, Weill Cornell Medical College, Department of Microbiology and Immunology
- March 2021 - December 2021: Assistant Professor, Weill Cornell Medical College, Department of Microbiology and Immunology
- February 2022 - Present: Assistant Professor, Southern University of Science and Technology, School of Life Sciences, Department of Biology
Academic Background & Achievements
- 2004-2008 Bachelor of Science: Sichuan University, Biological Sciences
- 2008-2013 PhD: Peking Union Medical College and Beijing Institute of Life Sciences, Biochemistry and Molecular Biology
Publications
- Type I Interferon Signaling Mediates Mycobacterium tuberculosis-Induced Macrophage Death, Zhang L, Jiang X, Pfau D, Ling Y, Nathan CF, 2021
- Structure and specificity of the bacterial cysteine methyltransferase effector NleE suggests a novel substrate in human DNA repair pathway, Yao Q, Zhang L, Wan X, Chen J, Hu L, Ding X, Li L, Karar J, Peng H, Chen S, Huang N, Rauscher FJ, Shao F, 2014
- Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains, Li S, Zhang L, Yao Q, Li L, Dong N, Rong J, Gao W, Ding X, Sun L, Chen X, Chen S, Shao F, 2013
- Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation, Zhang L, Ding X, Cui J, Xu H, Chen J, Gong YN, Hu L, Zhou Y, Ge J, Lu Q, Liu L, Chen S, Shao F, 2012
- Potentiation of rifampin activity in a mouse model of tuberculosis by activation of host transcription factor EB, Bryk R, Mundhra S, Jiang X, Wood M, Pfau D, Weber E, Park S, Zhang L, Wilson C, Van der Westhuyzen R, Street L, Chibale K, Zimmerman M, Dartois V, Pastore N, Ballabio A, Hawryluk N, Canan S, Khetani V, Camardo J, Nathan C, 2020
- Epithelial cells detect functional type III secretion system of enteropathogenic Escherichia coli through a novel NF-κB signaling pathway, Litvak Y, Sharon S, Hyams M, Zhang L, Kobi S, Katsowich N, Dishon S, Nussbaum G, Dong N, Shao F, Rosenshine I, 2017
- Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome, Xu H, Yang J, Gao W, Li L, Li P, Zhang L, Gong YN, Peng X, Xi J, Chen S, Wang F, Shao F, 2014
- The Plant-Specific Actin Binding Protein SCAB1 Stabilizes Actin Filaments and Regulates Stomatal Movement in Arabidopsis, Zhao Y, Zhao S, Mao T, Qu X, Cao W, Zhang L, Zhang W, He L, Li S, Ren S, Zhao J, Zhu G, Huang S, Ye K, Yuan M, Guo Y, 2011
Awards
- Cancer Research Institute/Robertson Foundation Fellow (2017): Cancer Research Institute
- Young Scientist Award (2014): 4th Asia Pacific Protein Association Conference
- Outstanding Graduate Student (2013, 2012): Peking Union Medical College
- Wu Rui Scholarship (2012): Wu Rui Foundation
- Outstanding Graduate Student (2011): Beijing Institute of Life Sciences
- Comprehensive Scholarship (2007): Sichuan University
- Huang Qianheng Scholarship (2006): Sichuan University
- National Scholarship (2005): Sichuan University
