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Jiwen Li
Life Science
East China Normal University
Shanghai
Language: English, Chinese
Chromatin
Dna Methylation
Histone Modification
Nucleosome Remodeling
Gene Expression
Nuclear Hormone Receptors
Transcription Suppression
Sumo Modification
Sumo-Bound Nucleosomes
Transcription Regulation
Areas of Focus
- Regulation of chromatin structure and function by DNA methylation, histone modification, and nucleosome remodeling
- Gene expression regulation mechanisms using nuclear hormone receptors as a model
- Molecular mechanisms of transcription suppression by SUMO modification and the role and mechanism of SUMO-bound nucleosomes in transcription regulation
Work Experience
- 1997/8-2007/5 - Baylor College of Medicine, Department of Molecular and Cellular Biology, Senior Research Assistant
- 2007/9 - Present - East China Normal University, School of Life Sciences, Senior Engineer
Academic Background & Achievements
- 1986-09 to 1990-06 Bachelor of Science in Biochemistry: Fudan University
- 1995-09 to 1997-05 Master of Science in Biomedical Science: Hood College, Supervisor: Dr. Yun-Bo Shi
Publications
- SET8 prevents excessive DNA methylation by methylation-mediated degradation of UHRF1 and DNMT1, Zhang, Huifang; Gao, Qinqin; Tan, Shuo; You, Jia; Lyu, Cong; Zhang, Yunpeng; Han, Mengmeng; Chen, Zhaosu; Li, Jialun; Wang, Hailin; Liao, Lujian; Qin, Jun; Li, Jiwen*; Wong, Jiemin*, 2019
- SUMOylation down-regulates rDNA transcription by repressing expression of upstream-binding factor and proto-oncogene c-Myc, Peng, Yu; Wang, Zhenxing; Wang, Zhiqiang; Yu, Fang; Li, Jiwen*; Wong, Jiemin*, 2019
- Activated MEK/ERK Pathway Drives Widespread and Coordinated Overexpression of UHRF1 and DNMT1 in Cancer cells, Li, Jialun; Wang, Ruiping; Hu, Xueli; Gao, Yingying; Wang, Zhen; Li, Jiwen*; Wong, Jiemin*, 2019
- SUMO suppresses and MYC amplifies transcription globally by regulating CDK9 sumoylation, Yu, Fang; Shi, Guang; Cheng, Shimeng; Chen, Jiwei; Wu, Shwu Yuan; Wang, Zhiqiang; Xia, Nansong; Zhai, Yunhao; Wang, Zhenxing; Peng, Yu; Wang, Dong; Du, James X; Liao, Lujian; Duan, Sheng Zhong; Shi, Tieliu; Cheng, Jinke; Chiang, Cheng Ming; Li, Jiwen*; Wong, Jiemin*, 2018
- MOF as an evolutionarily conserved histone crotonyltransferase and transcriptional activation by histone acetyltransferase-deficient and crotonyltransferase-competent CBP/p300, Liu Xiaoguang; Wei Wei; Liu Yuting; Yang Xueli; Wu Jian; Zhang Yang; Zhang Qiao; Shi Tieliu; Du James X; Zhao Yingming; Lei Ming; Zhou Jin Qiu; Li Jiwen*; Wong Jiemin*, 2017
