Professor | Yihua Chen | Asia Growth Partners

Name	Yihua Chen
Contact Information	yhchen@bio.ecnu.edu.cn
Language ability	Chinese, English
Province	Shanghai

Name

Yihua Chen

Contact Information

yhchen@bio.ecnu.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	East China Normal University
Faculty	Life Sciences
Academic Background & Achievements	1997-2001: Bachelor in Chemistry, Nanchang University 2001-2006: PhD in Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Supervisor: Nan Fajun
Work Experience	2009.12-2015.12: Associate Professor, East China Normal University, Shanghai Key Laboratory of Regulatory Biology 2015.12-2022.12: Researcher, East China Normal University, Shanghai Key Laboratory of Regulatory Biology 2022.12-present: Professor, East China Normal University, Shanghai Key Laboratory of Regulatory Biology
Awards	2015: The 18th Chinese Pharmaceutical Association - Sihuan Young Medicinal Chemist Award 2020: Excellent Mentor in the 6th China International 'Internet+' College Students Innovation and Entrepreneurship Competition, Shanghai

University/Lab Affiliation and Title

East China Normal University

Faculty

Life Sciences

Academic Background & Achievements

1997-2001: Bachelor in Chemistry, Nanchang University
2001-2006: PhD in Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Supervisor: Nan Fajun

Work Experience

2009.12-2015.12: Associate Professor, East China Normal University, Shanghai Key Laboratory of Regulatory Biology
2015.12-2022.12: Researcher, East China Normal University, Shanghai Key Laboratory of Regulatory Biology
2022.12-present: Professor, East China Normal University, Shanghai Key Laboratory of Regulatory Biology

Awards

2015: The 18th Chinese Pharmaceutical Association - Sihuan Young Medicinal Chemist Award
2020: Excellent Mentor in the 6th China International 'Internet+' College Students Innovation and Entrepreneurship Competition, Shanghai

Areas of Focus	Chemical Biology, Medicinal Chemistry Targeting Key Transcription Factors in Antitumor Pharmacology
Publications	Discovery of a Potent and Oral Complex I OXPHOS Inhibitor that Abrogates Tumor Growth and Circumvents MEKi Resistance, Peng He, Juanjuan Feng, Xinting Xia, Yue Sun, Jia He, Tian Guan, Yangrui Peng, Xueli Zhang, Mingyao Liu, Xiufeng Pang, Yihua Chen, 2023 Discovery of Pyrimidinediamine Derivatives as Potent Methuosis Inducers for the Treatment of Triple-Negative Breast Cancer, Jia He, Luzhen Wang, DaZhao Mi, Tian Guan, Wenjing Liu, Peng He, Haijun Gu, Yuzhan Li, Yangrui Peng, Ai-Qun Jia, Ceshi Chen, Yihua Chen, 2023 Discovery of a Highly Potent and Selective MYOF Inhibitor with Improved Water Solubility for the Treatment of Gastric Cancer, Haijun Gu, Ting Zhang, Tian Guan, Min Wu, Shen Li, Yunqi Li, Mengmeng Guo, Lin Zhang, Yangrui Peng, Dazhao Mi, Mingyao Liu, Zhengfang Yi, Yihua Chen, 2023

Areas of Focus

Chemical Biology, Medicinal Chemistry
Targeting Key Transcription Factors in Antitumor Pharmacology

Publications

Discovery of a Potent and Oral Complex I OXPHOS Inhibitor that Abrogates Tumor Growth and Circumvents MEKi Resistance, Peng He, Juanjuan Feng, Xinting Xia, Yue Sun, Jia He, Tian Guan, Yangrui Peng, Xueli Zhang, Mingyao Liu, Xiufeng Pang, Yihua Chen, 2023
Discovery of Pyrimidinediamine Derivatives as Potent Methuosis Inducers for the Treatment of Triple-Negative Breast Cancer, Jia He, Luzhen Wang, DaZhao Mi, Tian Guan, Wenjing Liu, Peng He, Haijun Gu, Yuzhan Li, Yangrui Peng, Ai-Qun Jia, Ceshi Chen, Yihua Chen, 2023
Discovery of a Highly Potent and Selective MYOF Inhibitor with Improved Water Solubility for the Treatment of Gastric Cancer, Haijun Gu, Ting Zhang, Tian Guan, Min Wu, Shen Li, Yunqi Li, Mengmeng Guo, Lin Zhang, Yangrui Peng, Dazhao Mi, Mingyao Liu, Zhengfang Yi, Yihua Chen, 2023

Chemical Biology Medicinal Chemistry Transcription Factors Antitumor Pharmacology Drug Design Cancer Therapy Molecular Inhibitors Small Molecules Targeted Therapy

Yihua Chen - East China Normal University

Hua Yuan - Shanghai Normal University

Qingyan Xu - Xiamen University

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