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Shi Ting
Life Science
Shanghai Jiao Tong University
Shanghai
Language: Chinese, English
Enzyme
Catalysis
Mechanisms
Bioinformatics
Structure-Function
Microbial
Drug Design
Computational Biology
Molecular Analysis
Atomic Analysis
Areas of Focus
- Enzyme catalysis mechanisms
- Bioinformatics analysis of enzyme structure-function relationships
- Microbial drug design
- Computational biology for molecular/atomic level analysis of key enzyme catalysis mechanisms
Work Experience
- 2010.07-2013.06 Assistant Researcher at Shanghai Jiao Tong University School of Medicine
- 2013.06-2014.12 Assistant Researcher at School of Life Sciences and Technology, Shanghai Jiao Tong University
- 2014.12-2022.12 Associate Researcher at School of Life Sciences and Technology, Shanghai Jiao Tong University
- 2022.12-present Researcher at School of Life Sciences and Technology, Shanghai Jiao Tong University
Academic Background & Achievements
- 2007.07-2010.07 Postdoctoral Fellow at Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- Developed 'pre-reactive state' model for rapid analysis of enzyme structure-function relationships
Publications
- Molecular Insights into Bifunctional Ambruticin DH3 for Substrate Specificity and Catalytic Mechanism, Shi Ting
- Insight into Substrate-assisted Catalytic Mechanism and Stereoselectivity of Bifunctional Nocardicin Thioesterase, Shi Ting
- Reductive inactivation of the hemiaminal pharmacophore for resistance against tetrahydroisoquinoline antibiotics, Shi Ting
- Discovery of Semi-Pinacolases from the Epoxide Hydrolase Family during Efficient Assembly of a Fungal Polyketide, Shi Ting
- Theoretical study on substrate recognition and catalytic mechanisms of gephyronic acid dehydratase DH1, Shi Ting
- Insight into Structural Characteristics of Protein-Substrate Interaction in Pimaricin Thioesterase, Shi Ting
- Theoretical Investigation of the Structural Characteristics in the Active State of Akt1 Kinase, Shi Ting
- Theoretical Studies on the Catalytic Mechanism and Substrate Diversity for Macrocyclization of Pikromycin Thioesterase, Shi Ting
Awards
- 2016, 2017 Shanghai Jiao Tong University 'Excellent Class Director'
- 2018 Second Prize in the Third Teaching Competition of the School of Life Sciences and Technology, Shanghai Jiao Tong University
- 2018 Third Prize in the Third Young Teachers Teaching Competition of Shanghai Jiao Tong University
- 2020 Third Prize as a mentor in the Fifth National College Students' Life Science Innovation and Entrepreneurship Competition
