Professor | Shi Le | Asia Growth Partners

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Name	Shi Le
Contact Information	leshi@xjtu.edu.cn
Language ability	Chinese, English
Province	Shaanxi

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Name

Shi Le

Contact Information

leshi@xjtu.edu.cn

Language ability

Chinese, English

Province

Shaanxi

University/Lab Affiliation and Title	Xi'an Jiaotong University
Faculty	Life Sciences
Academic Background & Achievements	2023-Present: Associate Professor at Xi'an Jiaotong University, School of Life Sciences and Technology 2019-2022: Assistant Professor at Xi'an Jiaotong University, School of Life Sciences and Technology 2019-2021: Postdoctoral Researcher at Xi'an Jiaotong University, School of Life Sciences and Technology 2013-2019: PhD in Biology from Xi'an Jiaotong University, School of Life Sciences and Technology 2016-2018: Joint PhD training at Harvard University, School of Medicine, Department of Pathology 2012-2013: Researcher at Tangdu Hospital, Fourth Military Medical University 2009-2012: Master's in Basic Medical Science from Northwest A&F University, College of Animal Medicine 2005-2009: Bachelor's in Biological Sciences from Northwest A&F University, College of Animal Medicine
Work Experience	2023-Present - Xi'an Jiaotong University, School of Life Sciences and Technology - Associate Professor 2019-2022 - Xi'an Jiaotong University, School of Life Sciences and Technology - Assistant Professor 2019-2021 - Xi'an Jiaotong University, School of Life Sciences and Technology - Postdoctoral Researcher 2012-2013 - Fourth Military Medical University, Tangdu Hospital - Researcher 2009-2012 - Northwest A&F University, College of Animal Medicine - Master's Student

University/Lab Affiliation and Title

Xi'an Jiaotong University

Faculty

Life Sciences

Academic Background & Achievements

2023-Present: Associate Professor at Xi'an Jiaotong University, School of Life Sciences and Technology
2019-2022: Assistant Professor at Xi'an Jiaotong University, School of Life Sciences and Technology
2019-2021: Postdoctoral Researcher at Xi'an Jiaotong University, School of Life Sciences and Technology
2013-2019: PhD in Biology from Xi'an Jiaotong University, School of Life Sciences and Technology
2016-2018: Joint PhD training at Harvard University, School of Medicine, Department of Pathology
2012-2013: Researcher at Tangdu Hospital, Fourth Military Medical University
2009-2012: Master's in Basic Medical Science from Northwest A&F University, College of Animal Medicine
2005-2009: Bachelor's in Biological Sciences from Northwest A&F University, College of Animal Medicine

Work Experience

2023-Present - Xi'an Jiaotong University, School of Life Sciences and Technology - Associate Professor
2019-2022 - Xi'an Jiaotong University, School of Life Sciences and Technology - Assistant Professor
2019-2021 - Xi'an Jiaotong University, School of Life Sciences and Technology - Postdoctoral Researcher
2012-2013 - Fourth Military Medical University, Tangdu Hospital - Researcher
2009-2012 - Northwest A&F University, College of Animal Medicine - Master's Student

Areas of Focus	Mechanisms of post-translational modifications of mitochondrial proteins in tumor and aging-related diseases and targeted drug research Mechanisms of gut microbiota in aging-related diseases and drug screening targeting gut microbiota to improve aging-related diseases
Publications	PET117 assembly factor stabilizes translation activator TACO1 thereby upregulates mitochondria-encoded cytochrome C oxidase 1 synthesis, Sun Qiong, Shi Le, and others, 2023 Hydrogen-Rich Water Ameliorates Metabolic Disorder via Modifying Gut Microbiota in Impaired Fasting Glucose Patients: A Randomized Controlled Study, Liang Bing, Shi Le, and others, 2023 Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle, Liu Jing, Shi Le, and others, 2021 Deubiquitinase OTUD6A promotes proliferation of cancer cells via regulating Drp1 stability and mitochondrial fission, Shi Le, and others, 2020 The functional analysis of Cullin7 E3 ubiquitin ligases in cancer, Shi Le, and others, 2020 Early interleukin-6 enhances hepatic ketogenesis in APPSWE/PSEN1dE9 mice via 3-hydroxy-3-methylglutary-CoA synthase 2 signaling activation by p38/nuclear factor κB p65, Shi Le, and others A modified culture strategy of human keratinocytes to shorten the primary culture time, Shi Le, Lei Zhanjun, and others, 2015

Areas of Focus

Mechanisms of post-translational modifications of mitochondrial proteins in tumor and aging-related diseases and targeted drug research
Mechanisms of gut microbiota in aging-related diseases and drug screening targeting gut microbiota to improve aging-related diseases

Publications

PET117 assembly factor stabilizes translation activator TACO1 thereby upregulates mitochondria-encoded cytochrome C oxidase 1 synthesis, Sun Qiong, Shi Le, and others, 2023
Hydrogen-Rich Water Ameliorates Metabolic Disorder via Modifying Gut Microbiota in Impaired Fasting Glucose Patients: A Randomized Controlled Study, Liang Bing, Shi Le, and others, 2023
Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle, Liu Jing, Shi Le, and others, 2021
Deubiquitinase OTUD6A promotes proliferation of cancer cells via regulating Drp1 stability and mitochondrial fission, Shi Le, and others, 2020
The functional analysis of Cullin7 E3 ubiquitin ligases in cancer, Shi Le, and others, 2020
Early interleukin-6 enhances hepatic ketogenesis in APPSWE/PSEN1dE9 mice via 3-hydroxy-3-methylglutary-CoA synthase 2 signaling activation by p38/nuclear factor κB p65, Shi Le, and others
A modified culture strategy of human keratinocytes to shorten the primary culture time, Shi Le, Lei Zhanjun, and others, 2015

Mitochondrial Proteins Post-Translational Modifications Tumor Aging-Related Diseases Targeted Drug Research Gut Microbiota Mechanisms Drug Screening Improvement Aging-Related Treatments

Changdong Lin - Tongji University

Yan Yan - University of Chinese Academy of Sciences

Jin He - Huazhong Agricultural University

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