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Shi Le
Life Science
Xi'an Jiaotong University
Shaanxi
Language: Chinese, English
Mitochondrial Proteins
Post-Translational Modifications
Tumor
Aging-Related Diseases
Targeted Drug Research
Gut Microbiota
Mechanisms
Drug Screening
Improvement
Aging-Related Treatments
Areas of Focus
- Mechanisms of post-translational modifications of mitochondrial proteins in tumor and aging-related diseases and targeted drug research
- Mechanisms of gut microbiota in aging-related diseases and drug screening targeting gut microbiota to improve aging-related diseases
Work Experience
- 2023-Present - Xi'an Jiaotong University, School of Life Sciences and Technology - Associate Professor
- 2019-2022 - Xi'an Jiaotong University, School of Life Sciences and Technology - Assistant Professor
- 2019-2021 - Xi'an Jiaotong University, School of Life Sciences and Technology - Postdoctoral Researcher
- 2012-2013 - Fourth Military Medical University, Tangdu Hospital - Researcher
- 2009-2012 - Northwest A&F University, College of Animal Medicine - Master's Student
Academic Background & Achievements
- 2023-Present: Associate Professor at Xi'an Jiaotong University, School of Life Sciences and Technology
- 2019-2022: Assistant Professor at Xi'an Jiaotong University, School of Life Sciences and Technology
- 2019-2021: Postdoctoral Researcher at Xi'an Jiaotong University, School of Life Sciences and Technology
- 2013-2019: PhD in Biology from Xi'an Jiaotong University, School of Life Sciences and Technology
- 2016-2018: Joint PhD training at Harvard University, School of Medicine, Department of Pathology
- 2012-2013: Researcher at Tangdu Hospital, Fourth Military Medical University
- 2009-2012: Master's in Basic Medical Science from Northwest A&F University, College of Animal Medicine
- 2005-2009: Bachelor's in Biological Sciences from Northwest A&F University, College of Animal Medicine
Publications
- PET117 assembly factor stabilizes translation activator TACO1 thereby upregulates mitochondria-encoded cytochrome C oxidase 1 synthesis, Sun Qiong, Shi Le, and others, 2023
- Hydrogen-Rich Water Ameliorates Metabolic Disorder via Modifying Gut Microbiota in Impaired Fasting Glucose Patients: A Randomized Controlled Study, Liang Bing, Shi Le, and others, 2023
- Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle, Liu Jing, Shi Le, and others, 2021
- Deubiquitinase OTUD6A promotes proliferation of cancer cells via regulating Drp1 stability and mitochondrial fission, Shi Le, and others, 2020
- The functional analysis of Cullin7 E3 ubiquitin ligases in cancer, Shi Le, and others, 2020
- Early interleukin-6 enhances hepatic ketogenesis in APPSWE/PSEN1dE9 mice via 3-hydroxy-3-methylglutary-CoA synthase 2 signaling activation by p38/nuclear factor κB p65, Shi Le, and others
- A modified culture strategy of human keratinocytes to shorten the primary culture time, Shi Le, Lei Zhanjun, and others, 2015
