Upload Avatar (500 x 500)
Liangxue Lai
Veterinary Medicine
Jilin University
Jilin
Language: Chinese, English
Embryology
Human Tissue
Neurology
Animal Models
Stem Cells
Therapy
Embryonic Stem Cells
Disease Models
Transgenic Technology
Antiviral Research
Areas of Focus
- Human tissue embryology
- Neurological disease animal models and stem cell therapy
- Embryonic stem cell banks for special diseases
- Development and reproduction of important mammalian models
- Transgenic technology for broad-spectrum antiviral research
Work Experience
- 1987.9-1990.10 Assistant, Veterinary University
- 1990.11-1997.10 Lecturer, Veterinary University
- 1997.11-1998.10 Associate Professor, Veterinary University
- 1998.1-2002.9 Postdoctoral Fellow, University of Missouri, USA
- 2002.10-2006.10 Research Assistant Professor, University of Missouri, USA
- 2007.10-present Professor, Jilin University
Academic Background & Achievements
- 1980.9-1984.7 Bachelor in Veterinary Science, Sichuan Veterinary College
- 1980.9-1983.7 Master in Basic Veterinary Science, Veterinary University
- 1992.9-1995.7 PhD in Bioengineering, Northeast Agricultural University
Publications
- Versatile and efficient in vivo genome editing with compact Streptococcus pasteurianus Cas9, Liangxue Lai, 2022
- CRISPR/Cas9-mediated gene correction in newborn rabbits with hereditary tyrosinemia type I, Liangxue Lai, 2021
- Generation of permanent neonatal diabetes mellitus dogs with glucokinase point mutations through base editing, Liangxue Lai, 2021
- ACBE, a new base editor for simultaneous C-to-T and A-to-G substitutions in mammalian systems, Liangxue Lai, 2020
- Development of a rabbit model of Wiskott-Aldrich syndrome, Liangxue Lai, 2020
- Efficient base editing for multiple genes and loci in pigs using base editors, Liangxue Lai, 2019
- XIST Derepression in Active X Chromosome Hinders Pig Somatic Cell Nuclear Transfer, Liangxue Lai, 2018
- Generation of ApoE deficient dogs via combination of embryo injection of CRISPR/Cas9 with somatic cell nuclear transfer, Liangxue Lai, 2018
- Engineering CRISPR /Cpf1 with tRNA promotes genome editing capability in mammalian systems, Liangxue Lai, 2018
- A huntingtin knockin pig model recapitulates features of selective neurodegeneration in huntington's disease, Liangxue Lai, 2018
- CRISPR-induced exon skipping is dependent on premature termination codon mutations, Liangxue Lai, 2018
- Highly efficient RNA-guided base editing in rabbit, Liangxue Lai, 2018
- Cre-dependent cas9-expressing pigs enable efficient in vivo genome editing, Liangxue Lai, 2017
Awards
- 2002 Medical Technology Highest Award, 'New Era of Technology' magazine, USA
- 2002 & 2006 Research featured among top 30 in 'Discovery' magazine's top 100 world science news
- 2005 Transgenic green pig featured in 'National Geographic' magazine, USA
- Recipient of the China Overseas Outstanding Youth Fund
- Recipient of the Special Government Allowance of the State Council
- Chief Scientist of the 973 Project
