Professor | Liangxue Lai | Asia Growth Partners

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Name	Liangxue Lai
Contact Information	lai_liangxue@gibh.ac.cn
Language ability	Chinese, English
Province	Jilin

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Name

Liangxue Lai

Contact Information

lai_liangxue@gibh.ac.cn

Language ability

Chinese, English

Province

Jilin

University/Lab Affiliation and Title	Jilin University
Faculty	Veterinary Medicine
Academic Background & Achievements	1980.9-1984.7 Bachelor in Veterinary Science, Sichuan Veterinary College 1980.9-1983.7 Master in Basic Veterinary Science, Veterinary University 1992.9-1995.7 PhD in Bioengineering, Northeast Agricultural University
Work Experience	1987.9-1990.10 Assistant, Veterinary University 1990.11-1997.10 Lecturer, Veterinary University 1997.11-1998.10 Associate Professor, Veterinary University 1998.1-2002.9 Postdoctoral Fellow, University of Missouri, USA 2002.10-2006.10 Research Assistant Professor, University of Missouri, USA 2007.10-present Professor, Jilin University
Awards	2002 Medical Technology Highest Award, 'New Era of Technology' magazine, USA 2002 & 2006 Research featured among top 30 in 'Discovery' magazine's top 100 world science news 2005 Transgenic green pig featured in 'National Geographic' magazine, USA Recipient of the China Overseas Outstanding Youth Fund Recipient of the Special Government Allowance of the State Council Chief Scientist of the 973 Project

University/Lab Affiliation and Title

Jilin University

Faculty

Veterinary Medicine

Academic Background & Achievements

1980.9-1984.7 Bachelor in Veterinary Science, Sichuan Veterinary College
1980.9-1983.7 Master in Basic Veterinary Science, Veterinary University
1992.9-1995.7 PhD in Bioengineering, Northeast Agricultural University

Work Experience

1987.9-1990.10 Assistant, Veterinary University
1990.11-1997.10 Lecturer, Veterinary University
1997.11-1998.10 Associate Professor, Veterinary University
1998.1-2002.9 Postdoctoral Fellow, University of Missouri, USA
2002.10-2006.10 Research Assistant Professor, University of Missouri, USA
2007.10-present Professor, Jilin University

Awards

2002 Medical Technology Highest Award, 'New Era of Technology' magazine, USA
2002 & 2006 Research featured among top 30 in 'Discovery' magazine's top 100 world science news
2005 Transgenic green pig featured in 'National Geographic' magazine, USA
Recipient of the China Overseas Outstanding Youth Fund
Recipient of the Special Government Allowance of the State Council
Chief Scientist of the 973 Project

Areas of Focus	Human tissue embryology Neurological disease animal models and stem cell therapy Embryonic stem cell banks for special diseases Development and reproduction of important mammalian models Transgenic technology for broad-spectrum antiviral research
Publications	Versatile and efficient in vivo genome editing with compact Streptococcus pasteurianus Cas9, Liangxue Lai, 2022 CRISPR/Cas9-mediated gene correction in newborn rabbits with hereditary tyrosinemia type I, Liangxue Lai, 2021 Generation of permanent neonatal diabetes mellitus dogs with glucokinase point mutations through base editing, Liangxue Lai, 2021 ACBE, a new base editor for simultaneous C-to-T and A-to-G substitutions in mammalian systems, Liangxue Lai, 2020 Development of a rabbit model of Wiskott-Aldrich syndrome, Liangxue Lai, 2020 Efficient base editing for multiple genes and loci in pigs using base editors, Liangxue Lai, 2019 XIST Derepression in Active X Chromosome Hinders Pig Somatic Cell Nuclear Transfer, Liangxue Lai, 2018 Generation of ApoE deficient dogs via combination of embryo injection of CRISPR/Cas9 with somatic cell nuclear transfer, Liangxue Lai, 2018 Engineering CRISPR /Cpf1 with tRNA promotes genome editing capability in mammalian systems, Liangxue Lai, 2018 A huntingtin knockin pig model recapitulates features of selective neurodegeneration in huntington's disease, Liangxue Lai, 2018 CRISPR-induced exon skipping is dependent on premature termination codon mutations, Liangxue Lai, 2018 Highly efficient RNA-guided base editing in rabbit, Liangxue Lai, 2018 Cre-dependent cas9-expressing pigs enable efficient in vivo genome editing, Liangxue Lai, 2017

Areas of Focus

Human tissue embryology
Neurological disease animal models and stem cell therapy
Embryonic stem cell banks for special diseases
Development and reproduction of important mammalian models
Transgenic technology for broad-spectrum antiviral research

Publications

Versatile and efficient in vivo genome editing with compact Streptococcus pasteurianus Cas9, Liangxue Lai, 2022
CRISPR/Cas9-mediated gene correction in newborn rabbits with hereditary tyrosinemia type I, Liangxue Lai, 2021
Generation of permanent neonatal diabetes mellitus dogs with glucokinase point mutations through base editing, Liangxue Lai, 2021
ACBE, a new base editor for simultaneous C-to-T and A-to-G substitutions in mammalian systems, Liangxue Lai, 2020
Development of a rabbit model of Wiskott-Aldrich syndrome, Liangxue Lai, 2020
Efficient base editing for multiple genes and loci in pigs using base editors, Liangxue Lai, 2019
XIST Derepression in Active X Chromosome Hinders Pig Somatic Cell Nuclear Transfer, Liangxue Lai, 2018
Generation of ApoE deficient dogs via combination of embryo injection of CRISPR/Cas9 with somatic cell nuclear transfer, Liangxue Lai, 2018
Engineering CRISPR /Cpf1 with tRNA promotes genome editing capability in mammalian systems, Liangxue Lai, 2018
A huntingtin knockin pig model recapitulates features of selective neurodegeneration in huntington's disease, Liangxue Lai, 2018
CRISPR-induced exon skipping is dependent on premature termination codon mutations, Liangxue Lai, 2018
Highly efficient RNA-guided base editing in rabbit, Liangxue Lai, 2018
Cre-dependent cas9-expressing pigs enable efficient in vivo genome editing, Liangxue Lai, 2017

Embryology Human Tissue Neurology Animal Models Stem Cells Therapy Embryonic Stem Cells Disease Models Transgenic Technology Antiviral Research

Zhengli Chen - Sichuan Agricultural University

Zhang Bing - China Agricultural University

Tingting Sui - Jilin University

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