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Peng Li
Life Science
Tsinghua University
Beijing
Language: English, Chinese
Glycolipid Metabolism
Lipid Droplet Biology
Obesity
Diabetes
Fatty Liver
Molecular Mechanisms
Lipid Droplet Fusion
Endoplasmic Reticulum Interactions
Mitochondria Interactions
Metabolic Diseases
Areas of Focus
- Study of glycolipid metabolism, including lipid droplet biology, molecular mechanisms of metabolic diseases such as obesity, diabetes, and fatty liver, focusing on the regulation of lipid droplet fusion, lipid droplet-endoplasmic reticulum, lipid droplet-mitochondria interactions, and their roles in the development of metabolic diseases.
Work Experience
- 1995-1996 - National University of Singapore, Institute of Molecular and Cell Biology - Postdoctoral Researcher
- 1996-1997 - University of Texas Southwestern Medical Center at Dallas, Howard Hughes Medical Institute - Postdoctoral Researcher
- 1997-2003 - Institute of Molecular and Cell Biology, Singapore - Assistant Professor and Laboratory Director
- 2003-2006 - Hong Kong University of Science and Technology, Department of Biology - Assistant Professor & Associate Professor (tenured)
- 2006-present - Tsinghua University, School of Life Sciences - Professor, PhD Supervisor
Academic Background & Achievements
- 1987 Bachelor: Beijing Normal University
- 1995 PhD: University of California, San Diego
Publications
- A gel-like condensation of Cidec generates lipid-permeable plates for lipid droplet fusion., Lyu X, Wang J, Wang J, Yin Y S, Zhu Y, Li L L, Huang S, Peng S, Xue B, Liao R, Wang S Q, Long M, Wohland T, Chua B T, Sun Y, Li P, Chen X W, Xu L, Chen F-J*, Li P*, 2021
- ORP5 localizes to ER-lipid droplet contacts and regulates the level of PI(4)P on lipid droplets., Du X, Zhou L, Aw Y, Mak HY, Xu Y, Rae J, Wang W, Zadoorian A, Hancock S, Osborne B, Chen X, Wu JW, Turner N, Parton RG, Li P*, and Yang H*, 2020
- Cideb controls sterol-regulated ER export of SREBP/SCAP by promoting cargo loading at ER exit sites., Su L, Zhou L, Chen FJ, Wang H, Qian H, Sheng Y, Zhu Y, Yu H, Gong X, Cai L, Yang X, Xu L, Zhao TJ, Li JZ, Chen X*, Li P*, 2019
- The Protein Phosphatase 1 Complex Is a Direct Target of AKT that Links Insulin Signaling to Hepatic Glycogen Deposition., Li Q, Zhao Q, Zhang J, Zhou L, Zhang W, Chua B, Chen Y, Xu L*, Li P*, 2019
- Rab18 promotes lipid droplet growth by tethering the ER to lipid droplets through SNARE and NRZ interactions., Xu D, Li Y, Wu L, Li Y, Zhao D, Yu J, Huang T, Ferguson C, Parton RG, Yang H, Li P*, 2018
- Coordination Among Lipid Droplets, Peroxisomes, and Mitochondria Regulates Energy Expenditure Through the CIDE-ATGL-PPARα Pathway in Adipocytes., Zhou L, Yu M, Arshad M, Wang W, Lu Y, Gong J, Gu Y, Li P*, Xu L*, 2018
- HDAC6-mediated acetylation of lipid droplet-binding protein CIDEC regulates fat-induced lipid storage., Qian H, Chen Y, Nian Z, Su L, Yu H, Chen FJ, Zhang X, Xu W, Zhou L, Liu J, Yu J, Yu L, Gao Y, Zhang H, Zhang H, Zhao S, Yu L, Xiao RP, Bao Y, Hou S, Li P, Li J, Deng H, Jia W, Li P*, 2017
- Insulin resistance and white adipose tissue inflammation are uncoupled in energetically challenged Fsp27 deficient mice., Zhou L, Park SY, Xu L, Xia X, Ye J, Su L, Jeong KH, Hur JH2, Oh H, Tamori Y, Zingaretti CM, Cinti S, Argente J, Yu M, Wu L, Ju S, Guan F,Yang H, Choi CS, Savage DB, Li P*, 2015
- Rab8a-AS160-MSS4 regulatory circuit controls lipid droplet fusion and growth., Wu L, Xu D, Zhou L, Xie B, Yu L, Yang H, Huang L, Ye J, Deng H, Yuan YA, Chen S, Li P*, 2014
- Perilipin1 promotes unilocular lipid droplet formation through activation of Fsp27 in adipocytes., Sun Z, Gong J, Wu H, Xu W, Wu L, Xu D, Gao J, Wu J, Yang H, Yang M, Li P*, 2013
- Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids., Wang W, Lv N, Zhang S, Shui G, Qian H, Zhang J, Chen Y, Ye J, Xie Y, Shen Y, Wenk MR, Li P*, 2012
- Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites., Gong J, Sun Z, Wu L, Xu W, Schieber N, Xu D, Shui G, Yang H, Parton RG, Li P*, 2011
- Cideb, an ER- and lipid droplet-associated protein, mediates VLDL lipidation and maturation by interacting with apolipoprotein B., Ye J, Li JZ, Liu Y, Li X, Yang T, Ma X, Li Q, Yao Z, Li P*, 2009
- Downregulation of AMP-activated protein kinase by Cidea-mediated ubiquitination and degradation in brown adipose tissue., Qi J, Gong J, Zhao T, Zhao J, Lam P, Ye J, Li JZ, Wu J, Zhou HM, Li P*, 2008
- Cidea-deficient mice have lean phenotype and are resistant to obesity., Zhou Z, Yon Toh S, Chen Z, Guo K, Ng CP, Ponniah S, Lin SC, Hong W, Li P*, 2003
Awards
- 2012: He Liang He Li Foundation Award for Scientific and Technological Progress in Life Sciences
- 2017-present: Vice Chairman of the Chinese Biophysical Society
- 2017-present: Chairman of the Metabolic Biology Branch of the Chinese Biophysical Society
- 2020-present: Editorial Board Member of Cell Metabolism
- Editor-in-Chief of Life Metabolism Magazine
