Professor | Peng Li | Asia Growth Partners

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Name	Peng Li
Contact Information	li-peng@mail.tsinghua.edu.cn
Language ability	English, Chinese
Province	Beijing

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Name

Peng Li

Contact Information

li-peng@mail.tsinghua.edu.cn

Language ability

English, Chinese

Province

Beijing

University/Lab Affiliation and Title	Tsinghua University
Faculty	Life Sciences
Academic Background & Achievements	1987 Bachelor: Beijing Normal University 1995 PhD: University of California, San Diego
Work Experience	1995-1996 - National University of Singapore, Institute of Molecular and Cell Biology - Postdoctoral Researcher 1996-1997 - University of Texas Southwestern Medical Center at Dallas, Howard Hughes Medical Institute - Postdoctoral Researcher 1997-2003 - Institute of Molecular and Cell Biology, Singapore - Assistant Professor and Laboratory Director 2003-2006 - Hong Kong University of Science and Technology, Department of Biology - Assistant Professor & Associate Professor (tenured) 2006-present - Tsinghua University, School of Life Sciences - Professor, PhD Supervisor
Awards	2012: He Liang He Li Foundation Award for Scientific and Technological Progress in Life Sciences 2017-present: Vice Chairman of the Chinese Biophysical Society 2017-present: Chairman of the Metabolic Biology Branch of the Chinese Biophysical Society 2020-present: Editorial Board Member of Cell Metabolism Editor-in-Chief of Life Metabolism Magazine

University/Lab Affiliation and Title

Tsinghua University

Faculty

Life Sciences

Academic Background & Achievements

1987 Bachelor: Beijing Normal University
1995 PhD: University of California, San Diego

Work Experience

1995-1996 - National University of Singapore, Institute of Molecular and Cell Biology - Postdoctoral Researcher
1996-1997 - University of Texas Southwestern Medical Center at Dallas, Howard Hughes Medical Institute - Postdoctoral Researcher
1997-2003 - Institute of Molecular and Cell Biology, Singapore - Assistant Professor and Laboratory Director
2003-2006 - Hong Kong University of Science and Technology, Department of Biology - Assistant Professor & Associate Professor (tenured)
2006-present - Tsinghua University, School of Life Sciences - Professor, PhD Supervisor

Awards

2012: He Liang He Li Foundation Award for Scientific and Technological Progress in Life Sciences
2017-present: Vice Chairman of the Chinese Biophysical Society
2017-present: Chairman of the Metabolic Biology Branch of the Chinese Biophysical Society
2020-present: Editorial Board Member of Cell Metabolism
Editor-in-Chief of Life Metabolism Magazine

Areas of Focus	Study of glycolipid metabolism, including lipid droplet biology, molecular mechanisms of metabolic diseases such as obesity, diabetes, and fatty liver, focusing on the regulation of lipid droplet fusion, lipid droplet-endoplasmic reticulum, lipid droplet-mitochondria interactions, and their roles in the development of metabolic diseases.
Publications	A gel-like condensation of Cidec generates lipid-permeable plates for lipid droplet fusion., Lyu X, Wang J, Wang J, Yin Y S, Zhu Y, Li L L, Huang S, Peng S, Xue B, Liao R, Wang S Q, Long M, Wohland T, Chua B T, Sun Y, Li P, Chen X W, Xu L, Chen F-J, Li P, 2021 ORP5 localizes to ER-lipid droplet contacts and regulates the level of PI(4)P on lipid droplets., Du X, Zhou L, Aw Y, Mak HY, Xu Y, Rae J, Wang W, Zadoorian A, Hancock S, Osborne B, Chen X, Wu JW, Turner N, Parton RG, Li P, and Yang H, 2020 Cideb controls sterol-regulated ER export of SREBP/SCAP by promoting cargo loading at ER exit sites., Su L, Zhou L, Chen FJ, Wang H, Qian H, Sheng Y, Zhu Y, Yu H, Gong X, Cai L, Yang X, Xu L, Zhao TJ, Li JZ, Chen X, Li P, 2019 The Protein Phosphatase 1 Complex Is a Direct Target of AKT that Links Insulin Signaling to Hepatic Glycogen Deposition., Li Q, Zhao Q, Zhang J, Zhou L, Zhang W, Chua B, Chen Y, Xu L, Li P, 2019 Rab18 promotes lipid droplet growth by tethering the ER to lipid droplets through SNARE and NRZ interactions., Xu D, Li Y, Wu L, Li Y, Zhao D, Yu J, Huang T, Ferguson C, Parton RG, Yang H, Li P, 2018 Coordination Among Lipid Droplets, Peroxisomes, and Mitochondria Regulates Energy Expenditure Through the CIDE-ATGL-PPARα Pathway in Adipocytes., Zhou L, Yu M, Arshad M, Wang W, Lu Y, Gong J, Gu Y, Li P, Xu L, 2018 HDAC6-mediated acetylation of lipid droplet-binding protein CIDEC regulates fat-induced lipid storage., Qian H, Chen Y, Nian Z, Su L, Yu H, Chen FJ, Zhang X, Xu W, Zhou L, Liu J, Yu J, Yu L, Gao Y, Zhang H, Zhang H, Zhao S, Yu L, Xiao RP, Bao Y, Hou S, Li P, Li J, Deng H, Jia W, Li P, 2017 Insulin resistance and white adipose tissue inflammation are uncoupled in energetically challenged Fsp27 deficient mice., Zhou L, Park SY, Xu L, Xia X, Ye J, Su L, Jeong KH, Hur JH2, Oh H, Tamori Y, Zingaretti CM, Cinti S, Argente J, Yu M, Wu L, Ju S, Guan F,Yang H, Choi CS, Savage DB, Li P, 2015 Rab8a-AS160-MSS4 regulatory circuit controls lipid droplet fusion and growth., Wu L, Xu D, Zhou L, Xie B, Yu L, Yang H, Huang L, Ye J, Deng H, Yuan YA, Chen S, Li P, 2014 Perilipin1 promotes unilocular lipid droplet formation through activation of Fsp27 in adipocytes., Sun Z, Gong J, Wu H, Xu W, Wu L, Xu D, Gao J, Wu J, Yang H, Yang M, Li P, 2013 Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids., Wang W, Lv N, Zhang S, Shui G, Qian H, Zhang J, Chen Y, Ye J, Xie Y, Shen Y, Wenk MR, Li P, 2012 Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites., Gong J, Sun Z, Wu L, Xu W, Schieber N, Xu D, Shui G, Yang H, Parton RG, Li P, 2011 Cideb, an ER- and lipid droplet-associated protein, mediates VLDL lipidation and maturation by interacting with apolipoprotein B., Ye J, Li JZ, Liu Y, Li X, Yang T, Ma X, Li Q, Yao Z, Li P, 2009 Downregulation of AMP-activated protein kinase by Cidea-mediated ubiquitination and degradation in brown adipose tissue., Qi J, Gong J, Zhao T, Zhao J, Lam P, Ye J, Li JZ, Wu J, Zhou HM, Li P, 2008 Cidea-deficient mice have lean phenotype and are resistant to obesity., Zhou Z, Yon Toh S, Chen Z, Guo K, Ng CP, Ponniah S, Lin SC, Hong W, Li P, 2003

Areas of Focus

Study of glycolipid metabolism, including lipid droplet biology, molecular mechanisms of metabolic diseases such as obesity, diabetes, and fatty liver, focusing on the regulation of lipid droplet fusion, lipid droplet-endoplasmic reticulum, lipid droplet-mitochondria interactions, and their roles in the development of metabolic diseases.

Publications

A gel-like condensation of Cidec generates lipid-permeable plates for lipid droplet fusion., Lyu X, Wang J, Wang J, Yin Y S, Zhu Y, Li L L, Huang S, Peng S, Xue B, Liao R, Wang S Q, Long M, Wohland T, Chua B T, Sun Y, Li P, Chen X W, Xu L, Chen F-J*, Li P*, 2021
ORP5 localizes to ER-lipid droplet contacts and regulates the level of PI(4)P on lipid droplets., Du X, Zhou L, Aw Y, Mak HY, Xu Y, Rae J, Wang W, Zadoorian A, Hancock S, Osborne B, Chen X, Wu JW, Turner N, Parton RG, Li P*, and Yang H*, 2020
Cideb controls sterol-regulated ER export of SREBP/SCAP by promoting cargo loading at ER exit sites., Su L, Zhou L, Chen FJ, Wang H, Qian H, Sheng Y, Zhu Y, Yu H, Gong X, Cai L, Yang X, Xu L, Zhao TJ, Li JZ, Chen X*, Li P*, 2019
The Protein Phosphatase 1 Complex Is a Direct Target of AKT that Links Insulin Signaling to Hepatic Glycogen Deposition., Li Q, Zhao Q, Zhang J, Zhou L, Zhang W, Chua B, Chen Y, Xu L*, Li P*, 2019
Rab18 promotes lipid droplet growth by tethering the ER to lipid droplets through SNARE and NRZ interactions., Xu D, Li Y, Wu L, Li Y, Zhao D, Yu J, Huang T, Ferguson C, Parton RG, Yang H, Li P*, 2018
Coordination Among Lipid Droplets, Peroxisomes, and Mitochondria Regulates Energy Expenditure Through the CIDE-ATGL-PPARα Pathway in Adipocytes., Zhou L, Yu M, Arshad M, Wang W, Lu Y, Gong J, Gu Y, Li P*, Xu L*, 2018
HDAC6-mediated acetylation of lipid droplet-binding protein CIDEC regulates fat-induced lipid storage., Qian H, Chen Y, Nian Z, Su L, Yu H, Chen FJ, Zhang X, Xu W, Zhou L, Liu J, Yu J, Yu L, Gao Y, Zhang H, Zhang H, Zhao S, Yu L, Xiao RP, Bao Y, Hou S, Li P, Li J, Deng H, Jia W, Li P*, 2017
Insulin resistance and white adipose tissue inflammation are uncoupled in energetically challenged Fsp27 deficient mice., Zhou L, Park SY, Xu L, Xia X, Ye J, Su L, Jeong KH, Hur JH2, Oh H, Tamori Y, Zingaretti CM, Cinti S, Argente J, Yu M, Wu L, Ju S, Guan F,Yang H, Choi CS, Savage DB, Li P*, 2015
Rab8a-AS160-MSS4 regulatory circuit controls lipid droplet fusion and growth., Wu L, Xu D, Zhou L, Xie B, Yu L, Yang H, Huang L, Ye J, Deng H, Yuan YA, Chen S, Li P*, 2014
Perilipin1 promotes unilocular lipid droplet formation through activation of Fsp27 in adipocytes., Sun Z, Gong J, Wu H, Xu W, Wu L, Xu D, Gao J, Wu J, Yang H, Yang M, Li P*, 2013
Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids., Wang W, Lv N, Zhang S, Shui G, Qian H, Zhang J, Chen Y, Ye J, Xie Y, Shen Y, Wenk MR, Li P*, 2012
Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites., Gong J, Sun Z, Wu L, Xu W, Schieber N, Xu D, Shui G, Yang H, Parton RG, Li P*, 2011
Cideb, an ER- and lipid droplet-associated protein, mediates VLDL lipidation and maturation by interacting with apolipoprotein B., Ye J, Li JZ, Liu Y, Li X, Yang T, Ma X, Li Q, Yao Z, Li P*, 2009
Downregulation of AMP-activated protein kinase by Cidea-mediated ubiquitination and degradation in brown adipose tissue., Qi J, Gong J, Zhao T, Zhao J, Lam P, Ye J, Li JZ, Wu J, Zhou HM, Li P*, 2008
Cidea-deficient mice have lean phenotype and are resistant to obesity., Zhou Z, Yon Toh S, Chen Z, Guo K, Ng CP, Ponniah S, Lin SC, Hong W, Li P*, 2003

Glycolipid Metabolism Lipid Droplet Biology Obesity Diabetes Fatty Liver Molecular Mechanisms Lipid Droplet Fusion Endoplasmic Reticulum Interactions Mitochondria Interactions Metabolic Diseases

Xiaoyan Pang - Shanghai Jiao Tong University

Su Haifeng - Shanghai University

Peng Li - Tsinghua University

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