2008-2013 PhD in Biochemistry and Molecular Biology, Wuhan University
2009-2012 Joint PhD Training, University of California, San Diego
2004-2008 Bachelor in Biotechnology, Wuhan University
2013-2016 Postdoctoral Researcher, Whitehead Institute for Biomedical Research, MIT
2016-present Researcher, School of Life Sciences, Peking University
2016-present Researcher, Peking University-Tsinghua University Center for Life Sciences
2013: Wu Rui Scholarship
2013: Hubei Province Outstanding Doctoral Thesis
2017: Yifang Scholar
2017-2022: Chief Scientist, National Key R&D Program Special Project for Youth
Research
RNA polymerase subunit regulation and disease-related research Systematic identification and molecular mechanisms of novel functions of RNA polymerase subunits Probe screening related to RNA polymerase subunits
Activated transcriptional elongation and RNA stability of GPCR ligand binding genes unveiled via RNA polymerase II degradation, Bao, L., Zhu, J., Shi, T., Jiang, Y., Li, B., Huang, J.*, Xiong Ji*, 2023
Subcellular localization shapes the fate of RNA polymerase III, Tian, K, Wang, R., Huang, J., Wang, H., Ji, X.*, 2023
Multiomic analysis of Cohesin reveals that ZBTB transcription factors contribute to chromatin interactions, Wang, R., Xu, Q., Wang, C., Tian, K., Wang, H., Ji, X.*, 2023
Protocol for quantitative analysis of RNA 3`-end processing induced by disassociated subunits using chromatin-associated RNA-seq data, Huang J*, Bao L, Zhu J, Ji X.*, 2023
Never a dull enzyme, RNA polymerase II, Huang, J.*, Ji, X.*, 2023
Meet the authors: The Ji lab, Ji X., Huang J., Zhu J., Duan W., Li Y., Bao L., 2023
Pol II preferentially regulates ribosomal protein expression by trapping disassociated subunits, Li, Y., Huang, J., Bao, L., Zhu, J., Duan, W., Zheng, H., Wang, H., Jiang, Y., Zhang, M., Yi, C., Ji, X.*, 2023
Droplet formation assay for investigating phase-separation mechanisms of RNA Pol II transcription and CTCF functioning, Wang, H., Zhou R., Ji, X.*, 2023
Linking chromatin acylation mark-defined proteome and genome in living cells, Qin, F.*, Li, B., Wang, H., Ma, S., Li, J., Liu, S., Kong, L., Zheng, H., Zhu, R., Han, Y., Yang, M., Li, K., Ji, X.*, Chen, P.*, 2023
Cross-regulome profiling of RNA polymerases highlights the regulatory role of polymerase III on mRNA transcription by maintaining local chromatin architecture, Jiang, Y., Huang, J., Tian, K., Zheng, H., Zhu, Y., Guo, T., Ji, X.*, 2022
The transcriptional coactivator RUVBL2 regulates Pol II clustering with diverse transcription factors, Wang, H., Zhou R., Ji, X.*, 2022
CTCF DNA binding domain undergoes dynamic and selective protein–protein interactions, Zhou, R., Tian, K., Huang, J., Duan, W., Fu, H., Feng, Y., Wang, H., Jiang, Y., Li, Y., Wang, R., Hu, J., Ma, H., Qi, Z.*, Ji X.*, 2022
Targeted protein degradation reveals Pol II heterogeneity and functional diversity, Li, Y., Huang. J., Zhu J., Bao, L., Wang, H., Jiang, Y., Tian, K., Wang, R., Zheng, H., Duan, W., Lai, W., Yi, X., Zhu, Y., Guo, T., Ji X.*, 2022
BRD2 interconnects with BRD3 to facilitate Pol II transcription initiation and elongation to prime promoters for cell differentiation, Wang, C., Xu, Q., Zhang, X., Day, D.S., Abraham, B.J., Lun, K., Chen, L., Huang, J. *, Ji, X. *, 2022
3D Landscape of Hepatitis B Virus with The Chromatin of Human Cells, Yang, B., Li, B., Jia, Li., Wang, X., Jiang, Y., Ji, X.*, Yang, P.*, 2020
Genome-wide Analyses of Chromatin Interactions After the Loss of Pol I, Pol II and Pol III, Jiang, Y., Huang, J., Lun, K., Li, B., Li, Y., Zheng, H., Li, Y., Zhou, R., Duan, W., Wang, C., Feng, Y., Yao, H., Li, C., Ji, X.*, 2020
Liquid-liquid Phase Separation in Biology: Mechanisms, Physiological Functions and Human Diseases, Zhang, H.*, Ji, X.*, Li, P.*, Liu, C.*, Lou, J.*, Wang, Z., Wen, W.*, Xiao, Y., Zhang, M.*, Zhu, X.*, 2020
BAT Hi-C Maps Global Chromatin Interactions in An Efficient and Economical Way, Huang, J.*, Jiang, Y., Zheng, H., Ji, X.*, 2020
3D Chromosome Regulatory Landscape of Human Pluripotent Cells, Ji, X., Dadon, D.B., Powell, B.E., Fan, Z.P., Borges-Rivera, D., Shachar, S., Weintraub, A.S., Hnisz, D., Pegoraro, G., Lee, T.I., et al., 2016
Editing DNA Methylation in the Mammalian Genome, Liu, X.S., Wu, H., Ji, X., Stelzer, Y., Wu, X., Czauderna, S., Shu, J., Dadon, D., Young, R.A., and Jaenisch, R., 2016
Transcription factor trapping by RNA in gene regulatory elements, Sigova, A.A., Abraham, B.J., Ji, X., Molinie, B., Hannett, N.M., Guo, Y.E., Jangi, M., Giallourakis, C.C., Sharp, P.A., and Young, R.A., 2015
Chromatin proteomic profiling reveals novel proteins associated with histone-marked genomic regions, Ji, X., Dadon, D.B., Abraham, B.J., Lee, T.I., Jaenisch, R., Bradner, J.E., and Young, R.A., 2015
Pre-mRNA splicing is facilitated by an optimal RNA polymerase II elongation rate, Fong, N., Kim, H., Zhou, Y., Ji, X., Qiu, J., Saldi, T., Diener, K., Jones, K., Fu, X.D., and Bentley, D.L., 2014
SR proteins collaborate with 7SK and promoter-associated nascent RNA to release paused polymerase, Ji, X., Zhou, Y., Pandit, S., Huang, J., Li, H., Lin, C.Y., Xiao, R., Burge, C.B., and Fu, X.D., 2013
The mediator couples transcription and splicing, Ji, X., and Fu, X.D., 2012
Pre-mRNA splicing: where and when in the nucleus, Han, J., Ji, X., Wang, D., and Fu, X.D., 2011
Genome-wide analysis of PTB-RNA interactions reveals a strategy used by the general splicing repressor to modulate exon inclusion or skipping, Xue, Y., Zhou, Y., Wu, T., Zhu, T., Ji, X., Kwon, Y.S., Zhang, C., Yeo, G., Black, D.L., Sun, H., et al., 2009
