1987 - 1991 Bachelor of Science in Cell Biology, Lanzhou University
1991 - 1994 Master of Science in Cell Biology, Lanzhou University
1994 - 1997 PhD in Cell Biology, Peking University
Chief Scientist of the National '973 Program'
1997-1999 Postdoctoral Researcher, Peking University
1999-2003 Research Associate, The Lerner Research Institute, CCF, USA
2003-2006 Research Associate, The Scripps Research Institute, USA
2006-2011 'Hundred Talents Program' Researcher, Peking University
2011-2012 Researcher, Peking University-Tsinghua University Center for Life Sciences
2012-present Senior Researcher, Peking University-Tsinghua University Center for Life Sciences
2011-present Distinguished Professor, Ministry of Education
National Outstanding Young Scientist Fund (2010)
Ministry of Education Distinguished Professor (2011)
Tan Jiazhen Life Science Innovation Award (2013)
National Excellent Doctoral Dissertation Advisor Award (2014)
Research
Infection-Immunity-Tumor and related cell signaling
ARMH3-mediated recruitment of PI4KB directs Golgi-to-endosome trafficking and activation of the antiviral effector STING, Fang R, Jiang Q, Jia X, Jiang Z*, 2023
Golgi-synthesized sulfated glycosaminoglycans mediate polymerization and activation of the cGAMP sensor STING, Fang R, Jiang Q, Guan Y, Gao P, Zhang R, Zhao Z, Jiang Z*, 2021
The STING Phase-separator Suppresses Innate Immune Signaling, Yu X, Zhang L, Shen J, Zhai Y, Jiang Q, Yi M, Deng X, Ruan Z, Fang R, Chen Z, Ning X, Jiang Z*, 2021
T6SS translocates a micropeptide to suppress STING-mediated innate immunity by sequestering manganese, Zhu L, Xi L, Wang C, Li C, Li M, Liu Q, Wang X, Yang W, Pan D, Hu L, Yang Y, Lu Z, Wang Y, Zhou D*, Jiang Z*, Shen X*, 2021
Manganese salts function as potent adjuvants, Zhang R, Wang C, Guan Y, Wei X, Sha M, Jing M, Lv M, Guo W, Xu J, Wan Y, Jia X, Jiang Z*, 2021
Differences in IFNβ secretion upon Rab1 inactivation in cells exposed to distinct innate immune stimuli, Yang J, Zhou X, Zhang R, Sun H, You F, Jiang Z*, 2021
Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy, Lv M. Chen M, Zhang R, Zhang W, Wang C, Zhang Y, Wei X, Guan Y, Liu J, Feng K, Jing M, Wang X, Liu Y, Mei Q*, Han W*, Jiang Z*, 2020
Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS and IRF3, Ning X, Wang Y, Jing M, Sha M, Lv M, Gao P, Zhang R, Huang X, Feng J, Jiang Z*, 2019
Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-stranded DNA and Is Required for the Host Defense against DNA Viruses, Wang C, Guan Y, Lv M, Zhang R, Guo Z, Wei X, Du X, Yang J, Li T, Wan Y, Su X, Huang X, Jiang Z*, 2018
Inflammasome activation triggers caspases-mediated cleavage of cGAS to regulate responses to DNA virus infection, Wang Y, Ning X, Gao P, Wu S, Sha M, Lv M, Zhou X, Gao J, Fang R, Meng G, Su X, Jiang Z*, 2017
Activation of STAT6 by STING is Critical for Antiviral Innate Immunity, Chen H, Sun H, You F, Sun W, Zhou X, Chen L, Yang J, Wang Y, Tang H, Guan Y, Xia W, Gu J, Ishikawa H, Gutman D, Barber G, Qin Z, Jiang Z*, 2011
PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4, You FP, Sun H, Zhou X, Sun WX, Liang SM, Zhai ZH & Jiang Z*, 2009
ERIS, an ER IFN stimulator, activates innate immune signaling through dimerization, Sun W, Li Y, Chen L, Chen H, You F, Zhou X, Zhou Y, Zhai Z, Chen D, Jiang Z*, 2009
Identification and characterization of phosphodiesterase V-cGAPs that specifically degrade 3`3`-cyclic GMP-AMP, Gao J, Tao J, Liang W, Zhao M, Du X, Cui S, Duan H, Kan B, Su X, Jiang Z*, 2015
MAVS activates TBK1 and IKKb through TRAFs in NEMO dependent and independent manner, Fang R, Lin Y, Zhou X, Wang C, Guan Y, Tao J, Xi J, Feng J, Jiang Z*, 2017
NEMO-IKKβ Are Essential for IRF3 and NF-κB Activation in the cGAS-STING Pathway, Fang R, Zhou X, Wang C, Guan Y, Tao J, Xi J, Feng J, Jiang Z*, 2017
Non-specific DNA binding by N-terminal domain promotes activation of human cyclic GMP-AMP synthase, Tao J, Zhang X, Jin J, Du X, Lian T, Yang J, Zhou X, Jiang Z*, Su X*, 2017
Cyclic (di)nucleotides: the common language shared by Microbe and Host, Gao J, Tao J, Liang W, Jiang Z*, 2016
The structural basis for the sensing and binding of cyclic di-GMP by STING, Huang YH, Liu XY, Du XX, Jiang Z, Su XD*, 2012
Poly(C)-binding protein 1 mediates house-keeping degradation of mitochondrial antiviral signaling (MAVS), Zhou X, You F, Chen H, Jiang Z*, 2012
Pellino 3b negatively regulates interleukin-1-induced TAK1-dependent NF kB activation, Xiao H, Qian W, Staschke K, Qian Y, Cui G, Deng L, Ehsani M, Wang X, Qian YW, Chen ZJ, Gilmour R, Jiang Z*, Li X*, 2008
Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis, Jiang Z, Georgel P, Li C, Choe J, Crozat K, Rutschmann S, Du X, Bigby T, Mudd S, Sovath S, Wilson I A, Olson A, Beutler B, 2006
CD14 is required for MyD88-independent LPS signaling, Jiang Z, Georgel P, Du X, Shamel L, Sovath S, Mudd S, Huber M, Kalis C, Keck S, Galanos C, Freudenberg M, Beutler B, 2005
Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta, Jiang Z, Mak TW, Sen G, Li X, 2004
Poly (I-C)-induced TLR3-mediated activation of NFkappa B and MAP kinase is through an IRAK-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR, Jiang Z, Johnson HJ, Nie H, Qin J, Bird TA, Li X, 2003
Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IRAK4-IRAK-TRAF6 complex, Jiang Z, Ninomiya-Tsuji J, Qian Y, Matsumoto K, Li X, 2002
Genetic Analysis of Host Resistance: Toll-like Receptor Signaling and Immunity at Large, Beutler B, Jiang Z, Georgel P, Crozat K, Croker B, Rutschmann S, Du X and Hoebe K, 2006
