Professor | Long Li | Asia Growth Partners

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Name	Long Li
Contact Information	{'en': 'Email: long_li (AT) pku.edu.cn', 'zh': '电子邮件：long_li (AT) pku.edu.cn', 'de': 'E-Mail: long_li (AT) pku.edu.cn'}
Language ability	Chinese, English
Province	Beijing

Upload Avatar (500 x 500)

Name

Long Li

Contact Information

{'en': 'Email: long_li (AT) pku.edu.cn', 'zh': '电子邮件：long_li (AT) pku.edu.cn', 'de': 'E-Mail: long_li (AT) pku.edu.cn'}

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	Peking University
Faculty	Life Sciences
Academic Background & Achievements	1999-2004 Bachelor: University of Science and Technology of China, School of Life Sciences 2004-2009 PhD: Purdue University, Department of Biology
Work Experience	2017-present Researcher, Peking University, School of Life Sciences 2017-present Researcher, Peking-Tsinghua Center for Life Sciences 2010-2017 Postdoctoral Fellow, Harvard Medical School 2009-2010 Postdoctoral Fellow, Purdue University, Department of Biology

University/Lab Affiliation and Title

Peking University

Faculty

Life Sciences

Academic Background & Achievements

1999-2004 Bachelor: University of Science and Technology of China, School of Life Sciences
2004-2009 PhD: Purdue University, Department of Biology

Work Experience

2017-present Researcher, Peking University, School of Life Sciences
2017-present Researcher, Peking-Tsinghua Center for Life Sciences
2010-2017 Postdoctoral Fellow, Harvard Medical School
2009-2010 Postdoctoral Fellow, Purdue University, Department of Biology

Areas of Focus	Transmembrane transport mechanisms of biomolecules Development and application of nanobody technology
Publications	Molecular pathway of mitochondrial preprotein import through the TOM-TIM23 supercomplex, Zhou X, Yang Y, Wang G, Wang S, Sun D, Ou X, Lian Y, Li L, 2023 Structural basis of SecA-mediated protein translocation, Dong L, Yang S, Chen J, Wu X, Sun D, Song C, Li L, 2023 Conformational changes of a phosphatidylcholine flippase in lipid membranes, Xu J, He Y, Wu X, Li L, 2022 Structure of the mitochondrial TIM22 complex from yeast, Zhang Y, Ou X, Wang X, Sun D, Zhou X, Wu X, Li Q, Li L, 2021 Structures of a P4-ATPase lipid flippase in lipid bilayers, He Y, Xu J, Wu X, Li L, 2020 Structure of the substrate-engaged SecA-SecY protein translocation machine, Ma C, Wu X, Sun D, Park E, Catipovic MA, Rapoport TA, Gao N, Li L, 2019 Structural and Mechanistic Insights into Protein Translocation, Rapoport TA, Li L, Park E, 2017 Crystal structure of a substrate-engaged SecY protein-translocation channel, Li L, Park E, Ling J, Ingram J, Ploegh H, Rapoport TA, 2016 Structural analysis and optimization of the covalent association between SpyCatcher and a peptide Tag, Li L, Fierer JO, Rapoport TA, Howarth M, 2014 A molecularly cloned, live-attenuated Japanese encephalitis vaccine SA14-14-2 virus: a conserved single amino acid in the ij Hairpin of the Viral E glycoprotein determines neurovirulence in mice, Yun SI, Song BH, Kim JK, Yun GN, Lee EY, Li L, Kuhn RJ, Rossmann MG, Morrey JD, Lee YM, 2014 Obstruction of Dengue Virus Maturation by Fab Fragments of the 2H2 Antibody, Wang Z, Li L, Pennington JG, Sheng J, Yap ML, Plevka P, Meng G, Sun L, Jiang W, Rossmann MG, 2013 Structural changes of envelope proteins during alphavirus fusion, Li L, Jose J, Xiang Y, Kuhn RJ, Rossmann MG, 2010 Crystallographic insights into the autocatalytic assembly mechanism of a bacteriophage tail spike, Xiang Y, Leiman PG, Li L, Grimes S, Anderson DL, Rossmann MG, 2009 Antiviral compounds discovered by virtual screening of small-molecule libraries against dengue virus E protein, Zhou Z, Khaliq M, Suk JE, Patkar C, Li L, Kuhn RJ, Post CB, 2008 The flavivirus precursor membrane-envelope protein complex: structure and maturation, Li L, Lok SM, Yu IM, Zhang Y, Kuhn RJ, Chen J, Rossmann MG, 2008 Structure of the immature dengue virus at low pH primes proteolytic maturation, Yu IM, Zhang W, Holdaway HA, Li L, Kostyuchenko VA, Chipman PR, Kuhn RJ, Rossmann MG, Chen J, 2008

Areas of Focus

Transmembrane transport mechanisms of biomolecules
Development and application of nanobody technology

Publications

Molecular pathway of mitochondrial preprotein import through the TOM-TIM23 supercomplex, Zhou X, Yang Y, Wang G, Wang S, Sun D, Ou X, Lian Y, Li L, 2023
Structural basis of SecA-mediated protein translocation, Dong L, Yang S, Chen J, Wu X, Sun D, Song C, Li L, 2023
Conformational changes of a phosphatidylcholine flippase in lipid membranes, Xu J, He Y, Wu X, Li L, 2022
Structure of the mitochondrial TIM22 complex from yeast, Zhang Y, Ou X, Wang X, Sun D, Zhou X, Wu X, Li Q, Li L, 2021
Structures of a P4-ATPase lipid flippase in lipid bilayers, He Y, Xu J, Wu X, Li L, 2020
Structure of the substrate-engaged SecA-SecY protein translocation machine, Ma C, Wu X, Sun D, Park E, Catipovic MA, Rapoport TA, Gao N, Li L, 2019
Structural and Mechanistic Insights into Protein Translocation, Rapoport TA, Li L, Park E, 2017
Crystal structure of a substrate-engaged SecY protein-translocation channel, Li L, Park E, Ling J, Ingram J, Ploegh H, Rapoport TA, 2016
Structural analysis and optimization of the covalent association between SpyCatcher and a peptide Tag, Li L, Fierer JO, Rapoport TA, Howarth M, 2014
A molecularly cloned, live-attenuated Japanese encephalitis vaccine SA14-14-2 virus: a conserved single amino acid in the ij Hairpin of the Viral E glycoprotein determines neurovirulence in mice, Yun SI, Song BH, Kim JK, Yun GN, Lee EY, Li L, Kuhn RJ, Rossmann MG, Morrey JD, Lee YM, 2014
Obstruction of Dengue Virus Maturation by Fab Fragments of the 2H2 Antibody, Wang Z, Li L, Pennington JG, Sheng J, Yap ML, Plevka P, Meng G, Sun L, Jiang W, Rossmann MG, 2013
Structural changes of envelope proteins during alphavirus fusion, Li L, Jose J, Xiang Y, Kuhn RJ, Rossmann MG, 2010
Crystallographic insights into the autocatalytic assembly mechanism of a bacteriophage tail spike, Xiang Y, Leiman PG, Li L, Grimes S, Anderson DL, Rossmann MG, 2009
Antiviral compounds discovered by virtual screening of small-molecule libraries against dengue virus E protein, Zhou Z, Khaliq M, Suk JE, Patkar C, Li L, Kuhn RJ, Post CB, 2008
The flavivirus precursor membrane-envelope protein complex: structure and maturation, Li L, Lok SM, Yu IM, Zhang Y, Kuhn RJ, Chen J, Rossmann MG, 2008
Structure of the immature dengue virus at low pH primes proteolytic maturation, Yu IM, Zhang W, Holdaway HA, Li L, Kostyuchenko VA, Chipman PR, Kuhn RJ, Rossmann MG, Chen J, 2008

Transmembrane Biomolecules Transport Cell Membrane Molecular Mechanism Disease Treatment Drug Targets Biochemistry Structural Biology Nanobody

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