Professor | Xu Dongyi | Asia Growth Partners

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Name	Xu Dongyi
Contact Information	{'en': 'Email: Xudongyi (AT) pku.edu.cn', 'zh': '电子邮件：Xudongyi (AT) pku.edu.cn', 'de': 'E-Mail: Xudongyi (AT) pku.edu.cn'}
Language ability	Chinese, English
Province	Beijing

Upload Avatar (500 x 500)

Name

Xu Dongyi

Contact Information

{'en': 'Email: Xudongyi (AT) pku.edu.cn', 'zh': '电子邮件：Xudongyi (AT) pku.edu.cn', 'de': 'E-Mail: Xudongyi (AT) pku.edu.cn'}

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	Peking University
Faculty	Life Sciences
Academic Background & Achievements	1999-2005 PhD in Life Sciences, Peking University 1995-1999 Bachelor of Science in Life Sciences, Peking University
Work Experience	2011 - Present, Researcher, Peking University, School of Life Sciences 2005 - 2011, Postdoctoral Fellow, National Institutes of Health (NIH)

University/Lab Affiliation and Title

Peking University

Faculty

Life Sciences

Academic Background & Achievements

1999-2005 PhD in Life Sciences, Peking University
1995-1999 Bachelor of Science in Life Sciences, Peking University

Work Experience

2011 - Present, Researcher, Peking University, School of Life Sciences
2005 - 2011, Postdoctoral Fellow, National Institutes of Health (NIH)

Areas of Focus	Genomic instability including mutations and chromosomal structural variations DNA damage response systems Development of synthetic lethal strategies for cancer drugs
Publications	Epstein-Barr virus protein BKRF4 restricts nucleosome assembly to suppress host antiviral responses, Chen J, Lu Z, Gong W, Xiao X, Feng X, Li W, Shan S, Xu D, Zhou Z, 2022 RIF1-ASF1-mediated high-order chromatin structure safeguards genome integrity, Feng S, Ma S, Li K, Gao S, Ning S, Shang J, Guo R, Chen Y, Blumenfeld B, Simon I, Li Q, Guo R, Xu D, 2022 Fanconi anemia proteins participate in a break-induced-replication-like pathway to counter replication stress, Xu X, Xu Y, Guo R, Xu R, Fu C, Xing M, Sasanuma H, Li Q, Takata M, Takeda S, Guo R* and Xu D, 2021 The nucleoskeleton protein IFFO1 immobilizes broken DNA and suppresses chromosome translocation during tumorigenesis, Li W, Bai X, Li J, Zhao Y, Liu J, Zhao H, Liu L, Ding M, Wang Q, Shi F-Y, Hou M, Ji J, Gao G, Guo R, Sun Y, Liu Y, Xu D, 2019 A mitosis-specific MRN complex promotes a mitotic signaling cascade to regulate spindle dynamics and chromosome segregation, Xu R, Xu Y, Huo W, Lv Z, Yuan J, Ning S, Wang Q, Hou M, Gao G, Ji J, Chen J, Guo R, Xu D, 2018 An OB-fold complex controls the repair pathways for DNA double-strand breaks, Gao S, Feng S, Ning S, Liu J, Zhao H, Xu Y, Shang J, Li K, Li Q, Guo R, Xu D, 2018 53BP1 and BRCA1 control pathway choice for stalled replication restart, Xu Y, Ning S, Wei Z, Xu R, Xu X, Xing M, Guo R and Xu D, 2017 Topoisomerase 3β is the major topoisomerase for mRNAs and linked to neurodevelopment and mental dysfunction, Ahmad M, Shen W, Li W, Xue Y, Zou S, Xu D, Wang W, 2017 Ewing Tumor-Associated Antigen 1 Interacts with Replication Protein A to Promote Restart of Stalled Replication Forks, Feng S, Zhao Y, Xu Y, Ning S, Hou W, Hou M, Gao G, Ji J, Guo R, Xu D, 2016 RNA topoisomerase is prevalent in all domains of life and associates with polyribosomes in animals, Ahmad M, Xue Y, Lee SK, Martindale JL, Shen W, Li W, Zou S, Ciaramella M, Debat H, Nadal M, Leng F, Zhang H, Wang Q, Siaw GE, Niu H, Pommier Y, Gorospe M, Hsieh TS, Tse-Dinh YC, Xu D, Wang W, 2016 Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway, Xing M, Yang M, Huo W, Feng F, Wei L, Jiang W, Ning S, Yan Z, Li W, Wang Q, Hou M, Dong C, Guo R, Gao G, Ji J, Zha S, Lan L, Liang H, Xu D, 2015 A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice, Escribano-Díaz C, Orthwein A, Fradet-Turcotte A, Xing M, Young JT, Tkáč J, Cook MA, Rosebrock AP, Munro M, Canny MD, Xu D, Durocher D.A, 2013

Areas of Focus

Genomic instability including mutations and chromosomal structural variations
DNA damage response systems
Development of synthetic lethal strategies for cancer drugs

Publications

Epstein-Barr virus protein BKRF4 restricts nucleosome assembly to suppress host antiviral responses, Chen J, Lu Z, Gong W, Xiao X, Feng X, Li W, Shan S, Xu D*, Zhou Z*, 2022
RIF1-ASF1-mediated high-order chromatin structure safeguards genome integrity, Feng S, Ma S, Li K, Gao S, Ning S, Shang J, Guo R, Chen Y, Blumenfeld B, Simon I, Li Q, Guo R, Xu D*, 2022
Fanconi anemia proteins participate in a break-induced-replication-like pathway to counter replication stress, Xu X, Xu Y*, Guo R, Xu R, Fu C, Xing M, Sasanuma H, Li Q, Takata M, Takeda S, Guo R* and Xu D*, 2021
The nucleoskeleton protein IFFO1 immobilizes broken DNA and suppresses chromosome translocation during tumorigenesis, Li W, Bai X, Li J, Zhao Y, Liu J, Zhao H, Liu L, Ding M, Wang Q, Shi F-Y, Hou M, Ji J, Gao G, Guo R, Sun Y, Liu Y*, Xu D*, 2019
A mitosis-specific MRN complex promotes a mitotic signaling cascade to regulate spindle dynamics and chromosome segregation, Xu R, Xu Y, Huo W, Lv Z, Yuan J, Ning S, Wang Q, Hou M, Gao G, Ji J, Chen J, Guo R*, Xu D*, 2018
An OB-fold complex controls the repair pathways for DNA double-strand breaks, Gao S, Feng S, Ning S, Liu J, Zhao H, Xu Y, Shang J, Li K, Li Q, Guo R*, Xu D*, 2018
53BP1 and BRCA1 control pathway choice for stalled replication restart, Xu Y, Ning S, Wei Z, Xu R, Xu X, Xing M, Guo R* and Xu D*, 2017
Topoisomerase 3β is the major topoisomerase for mRNAs and linked to neurodevelopment and mental dysfunction, Ahmad M, Shen W, Li W, Xue Y, Zou S, Xu D*, Wang W*, 2017
Ewing Tumor-Associated Antigen 1 Interacts with Replication Protein A to Promote Restart of Stalled Replication Forks, Feng S, Zhao Y, Xu Y, Ning S, Hou W, Hou M, Gao G, Ji J, Guo R*, Xu D*, 2016
RNA topoisomerase is prevalent in all domains of life and associates with polyribosomes in animals, Ahmad M, Xue Y, Lee SK, Martindale JL, Shen W, Li W, Zou S, Ciaramella M, Debat H, Nadal M, Leng F, Zhang H, Wang Q, Siaw GE, Niu H, Pommier Y, Gorospe M, Hsieh TS, Tse-Dinh YC, Xu D*, Wang W*, 2016
Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway, Xing M, Yang M, Huo W, Feng F, Wei L, Jiang W, Ning S, Yan Z, Li W, Wang Q, Hou M, Dong C, Guo R, Gao G, Ji J, Zha S, Lan L, Liang H, Xu D*, 2015
A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice, Escribano-Díaz C, Orthwein A, Fradet-Turcotte A, Xing M, Young JT, Tkáč J, Cook MA, Rosebrock AP, Munro M, Canny MD, Xu D*, Durocher D.A*, 2013

Genomic Instability Mutations Chromosomal Variations Dna Damage Cancer Cells Synthetic Lethal Drug Development Dna Repair Cancer Treatment Molecular Mechanisms

Songcheng Zhu - Tongji University

Zhengfang Yi - East China Normal University

Meifang Qi - University of Chinese Academy of Sciences

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