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Xu Dongyi
Life Science
Peking University
Beijing
Language: Chinese, English
Genomic Instability
Mutations
Chromosomal Variations
Dna Damage
Cancer Cells
Synthetic Lethal
Drug Development
Dna Repair
Cancer Treatment
Molecular Mechanisms
Areas of Focus
- Genomic instability including mutations and chromosomal structural variations
- DNA damage response systems
- Development of synthetic lethal strategies for cancer drugs
Work Experience
- 2011 - Present, Researcher, Peking University, School of Life Sciences
- 2005 - 2011, Postdoctoral Fellow, National Institutes of Health (NIH)
Academic Background & Achievements
- 1999-2005 PhD in Life Sciences, Peking University
- 1995-1999 Bachelor of Science in Life Sciences, Peking University
Publications
- Epstein-Barr virus protein BKRF4 restricts nucleosome assembly to suppress host antiviral responses, Chen J, Lu Z, Gong W, Xiao X, Feng X, Li W, Shan S, Xu D*, Zhou Z*, 2022
- RIF1-ASF1-mediated high-order chromatin structure safeguards genome integrity, Feng S, Ma S, Li K, Gao S, Ning S, Shang J, Guo R, Chen Y, Blumenfeld B, Simon I, Li Q, Guo R, Xu D*, 2022
- Fanconi anemia proteins participate in a break-induced-replication-like pathway to counter replication stress, Xu X, Xu Y*, Guo R, Xu R, Fu C, Xing M, Sasanuma H, Li Q, Takata M, Takeda S, Guo R* and Xu D*, 2021
- The nucleoskeleton protein IFFO1 immobilizes broken DNA and suppresses chromosome translocation during tumorigenesis, Li W, Bai X, Li J, Zhao Y, Liu J, Zhao H, Liu L, Ding M, Wang Q, Shi F-Y, Hou M, Ji J, Gao G, Guo R, Sun Y, Liu Y*, Xu D*, 2019
- A mitosis-specific MRN complex promotes a mitotic signaling cascade to regulate spindle dynamics and chromosome segregation, Xu R, Xu Y, Huo W, Lv Z, Yuan J, Ning S, Wang Q, Hou M, Gao G, Ji J, Chen J, Guo R*, Xu D*, 2018
- An OB-fold complex controls the repair pathways for DNA double-strand breaks, Gao S, Feng S, Ning S, Liu J, Zhao H, Xu Y, Shang J, Li K, Li Q, Guo R*, Xu D*, 2018
- 53BP1 and BRCA1 control pathway choice for stalled replication restart, Xu Y, Ning S, Wei Z, Xu R, Xu X, Xing M, Guo R* and Xu D*, 2017
- Topoisomerase 3β is the major topoisomerase for mRNAs and linked to neurodevelopment and mental dysfunction, Ahmad M, Shen W, Li W, Xue Y, Zou S, Xu D*, Wang W*, 2017
- Ewing Tumor-Associated Antigen 1 Interacts with Replication Protein A to Promote Restart of Stalled Replication Forks, Feng S, Zhao Y, Xu Y, Ning S, Hou W, Hou M, Gao G, Ji J, Guo R*, Xu D*, 2016
- RNA topoisomerase is prevalent in all domains of life and associates with polyribosomes in animals, Ahmad M, Xue Y, Lee SK, Martindale JL, Shen W, Li W, Zou S, Ciaramella M, Debat H, Nadal M, Leng F, Zhang H, Wang Q, Siaw GE, Niu H, Pommier Y, Gorospe M, Hsieh TS, Tse-Dinh YC, Xu D*, Wang W*, 2016
- Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway, Xing M, Yang M, Huo W, Feng F, Wei L, Jiang W, Ning S, Yan Z, Li W, Wang Q, Hou M, Dong C, Guo R, Gao G, Ji J, Zha S, Lan L, Liang H, Xu D*, 2015
- A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice, Escribano-Díaz C, Orthwein A, Fradet-Turcotte A, Xing M, Young JT, Tkáč J, Cook MA, Rosebrock AP, Munro M, Canny MD, Xu D*, Durocher D.A*, 2013
