Professor | Zhang Di | Asia Growth Partners

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Name	Zhang Di
Contact Information	{'en': 'Email: zhangdi (AT) pku.edu.cn, Office Phone: 62750437, Lab Phone: 62750430', 'zh': '电子邮件：zhangdi (AT) pku.edu.cn, 办公室电话：62750437, 实验室电话：62750430', 'de': 'E-Mail: zhangdi (AT) pku.edu.cn, Bürotelefon: 62750437, Labortelefon: 62750430'}
Language ability	English, Chinese
Province	Beijing

Upload Avatar (500 x 500)

Name

Zhang Di

Contact Information

{'en': 'Email: zhangdi (AT) pku.edu.cn, Office Phone: 62750437, Lab Phone: 62750430', 'zh': '电子邮件：zhangdi (AT) pku.edu.cn, 办公室电话：62750437, 实验室电话：62750430', 'de': 'E-Mail: zhangdi (AT) pku.edu.cn, Bürotelefon: 62750437, Labortelefon: 62750430'}

Language ability

English, Chinese

Province

Beijing

University/Lab Affiliation and Title	Peking University
Faculty	Life Sciences
Academic Background & Achievements	2010 - 2013, PhD in Biochemistry and Molecular Biology, Peking University 2005 - 2010, Bachelor of Medicine in Basic Medical Sciences, Peking University
Work Experience	2021.3 - Present, Researcher, Peking University-Tsinghua University Center for Life Sciences 2021.3 - Present, Researcher, College of Life Sciences, Peking University 2013.9 - 2021.1, Postdoctoral Researcher, University of Chicago, Ben May Department for Cancer Research
Awards	22nd Young Teacher Basic Skills Competition First Prize, Excellent Teaching Plan Award, Best Teaching Demonstration Award, Most Popular Teacher Award, Course Ideology and Politics Award, 2023 Boya Young Scholar, 2022 Bayer Scholar, 2021 Yifang Scholar, 2021

University/Lab Affiliation and Title

Peking University

Faculty

Life Sciences

Academic Background & Achievements

2010 - 2013, PhD in Biochemistry and Molecular Biology, Peking University
2005 - 2010, Bachelor of Medicine in Basic Medical Sciences, Peking University

Work Experience

2021.3 - Present, Researcher, Peking University-Tsinghua University Center for Life Sciences
2021.3 - Present, Researcher, College of Life Sciences, Peking University
2013.9 - 2021.1, Postdoctoral Researcher, University of Chicago, Ben May Department for Cancer Research

Awards

22nd Young Teacher Basic Skills Competition First Prize, Excellent Teaching Plan Award, Best Teaching Demonstration Award, Most Popular Teacher Award, Course Ideology and Politics Award, 2023
Boya Young Scholar, 2022
Bayer Scholar, 2021
Yifang Scholar, 2021

Areas of Focus	Discovery of novel protein modifications driven by metabolites and their functions Exploration of how metabolites regulate chromatin structure and function, affecting gene expression and cell fate Study of metabolic enzymes in metabolic adaptation and regulation, understanding complex roles in cell physiology and disease
Publications	Lactylation constrains OXPHOS under hypoxia, Ren H, Zhang D, 2024 Identification of 113 new histone marks by CHiMA, a tailored database search strategy, Gao J, Sheng X, Du J, Zhang D, Han C, Chen Y, Wang C, Zhao Y, 2023 Class I histone deacetylases (HDAC1-3) are histone lysine delactylases, Moreno-Yruela C, Zhang D, Wei W, Bæk M, Liu W, Gao J, Danková D, Nielsen AL, Bolding JE, Yang L, Jameson ST, Wong J, Olsen CA, Zhao Y, 2022 The regulatory enzymes and protein substrates for the lysine β-hydroxybutyrylation pathway, Huang H, Zhang D, Weng Y, Delaney K, Tang Z, Yan C, Qi S, Peng C, Cole PA, Roeder RG, Zhao Y, 2021 Metabolic regulation of gene expression by histone lactylation, Zhang D, Tang Z, Huang H, Zhou G, Cui C, Weng Y, Liu W, Kim S, Lee S, Perez-Neut M, Czyz D, Hu R, Ye Z, He M, Zheng YG, Shuman H, Ding J, Dai L, Ren B, Robert RG, Becker L, Zhao Y, 2019 Lysine benzoylation is a histone mark regulated by SIRT2, Huang H, Zhang D, Wang Y, Perez-Neut M, Han Z, Zheng YG, Hao Q, Zhao Y, 2018 Metabolic Regulation of Gene Expression through Differential Histone Acylation, Sabari BR, Zhang D, Allis CD, Zhao Y, 2017 Metabolic Regulation of Gene Expression by Histone Lysine beta-hydroxybutyrylation, Xie Z, Zhang D, Chung D, Tang Z, Huang H, Dai L, Qi S, Li J, Colak G, Chen Y, Xia C, Peng C, Ruan H, Kirkey M, Wang D, Jensen LM, Kwon OK, Lee S, Pletcher SD, Tan M, Lombard DB, White KP, Zhao H, Li J, Roeder RG, Yang X, Zhao Y, 2016 Dynamic Competing Histone H4 K5K8 Acetylation and Butyrylation Are Hallmarks of Highly Active Gene Promoters, Goudarzi A, Zhang D, Huang H, Barral S, Kwon OK, Qi S, Tang Z, Buchou T, Vitte AL, He T, Cheng Z, Montellier E, Gaucher J, Curtet S, Debernardi A, Charbonnier G, Puthier D, Petosa C, Panne D, Rousseaux S, Roeder RG, Zhao Y, Khochbin S, 2016 Nucleation of DNA Repair Factors by FOXA1 Links DNA Demethylation to Transcriptional Pioneering, Zhang Y, Zhang D, Liang J, Yi X, Gui B, Yu W, Sun L, Yang X, Han X, Chen Z, Liu S, Si W, Yan R, Wang Y, Shang Y

Areas of Focus

Discovery of novel protein modifications driven by metabolites and their functions
Exploration of how metabolites regulate chromatin structure and function, affecting gene expression and cell fate
Study of metabolic enzymes in metabolic adaptation and regulation, understanding complex roles in cell physiology and disease

Publications

Lactylation constrains OXPHOS under hypoxia, Ren H, Zhang D, 2024
Identification of 113 new histone marks by CHiMA, a tailored database search strategy, Gao J, Sheng X, Du J, Zhang D, Han C, Chen Y, Wang C, Zhao Y, 2023
Class I histone deacetylases (HDAC1-3) are histone lysine delactylases, Moreno-Yruela C, Zhang D, Wei W, Bæk M, Liu W, Gao J, Danková D, Nielsen AL, Bolding JE, Yang L, Jameson ST, Wong J, Olsen CA, Zhao Y, 2022
The regulatory enzymes and protein substrates for the lysine β-hydroxybutyrylation pathway, Huang H, Zhang D, Weng Y, Delaney K, Tang Z, Yan C, Qi S, Peng C, Cole PA, Roeder RG, Zhao Y, 2021
Metabolic regulation of gene expression by histone lactylation, Zhang D, Tang Z, Huang H, Zhou G, Cui C, Weng Y, Liu W, Kim S, Lee S, Perez-Neut M, Czyz D, Hu R, Ye Z, He M, Zheng YG, Shuman H, Ding J, Dai L, Ren B, Robert RG, Becker L, Zhao Y, 2019
Lysine benzoylation is a histone mark regulated by SIRT2, Huang H, Zhang D, Wang Y, Perez-Neut M, Han Z, Zheng YG, Hao Q, Zhao Y, 2018
Metabolic Regulation of Gene Expression through Differential Histone Acylation, Sabari BR, Zhang D, Allis CD, Zhao Y, 2017
Metabolic Regulation of Gene Expression by Histone Lysine beta-hydroxybutyrylation, Xie Z, Zhang D, Chung D, Tang Z, Huang H, Dai L, Qi S, Li J, Colak G, Chen Y, Xia C, Peng C, Ruan H, Kirkey M, Wang D, Jensen LM, Kwon OK, Lee S, Pletcher SD, Tan M, Lombard DB, White KP, Zhao H, Li J, Roeder RG, Yang X, Zhao Y, 2016
Dynamic Competing Histone H4 K5K8 Acetylation and Butyrylation Are Hallmarks of Highly Active Gene Promoters, Goudarzi A, Zhang D, Huang H, Barral S, Kwon OK, Qi S, Tang Z, Buchou T, Vitte AL, He T, Cheng Z, Montellier E, Gaucher J, Curtet S, Debernardi A, Charbonnier G, Puthier D, Petosa C, Panne D, Rousseaux S, Roeder RG, Zhao Y, Khochbin S, 2016
Nucleation of DNA Repair Factors by FOXA1 Links DNA Demethylation to Transcriptional Pioneering, Zhang Y, Zhang D, Liang J, Yi X, Gui B, Yu W, Sun L, Yang X, Han X, Chen Z, Liu S, Si W, Yan R, Wang Y, Shang Y

Metabolites Protein Modifications Gene Regulation Chromatin Structure Cell Fate Metabolic Enzymes Cell Physiology Disease Mechanisms Biochemistry Molecular Biology

Yanfang Wang - Tongji University

Shaojun Dai - Shanghai Normal University

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