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Zhang Di
Life Science
Peking University
Beijing
Language: English, Chinese
Metabolites
Protein Modifications
Gene Regulation
Chromatin Structure
Cell Fate
Metabolic Enzymes
Cell Physiology
Disease Mechanisms
Biochemistry
Molecular Biology
Areas of Focus
- Discovery of novel protein modifications driven by metabolites and their functions
- Exploration of how metabolites regulate chromatin structure and function, affecting gene expression and cell fate
- Study of metabolic enzymes in metabolic adaptation and regulation, understanding complex roles in cell physiology and disease
Work Experience
- 2021.3 - Present, Researcher, Peking University-Tsinghua University Center for Life Sciences
- 2021.3 - Present, Researcher, College of Life Sciences, Peking University
- 2013.9 - 2021.1, Postdoctoral Researcher, University of Chicago, Ben May Department for Cancer Research
Academic Background & Achievements
- 2010 - 2013, PhD in Biochemistry and Molecular Biology, Peking University
- 2005 - 2010, Bachelor of Medicine in Basic Medical Sciences, Peking University
Publications
- Lactylation constrains OXPHOS under hypoxia, Ren H, Zhang D, 2024
- Identification of 113 new histone marks by CHiMA, a tailored database search strategy, Gao J, Sheng X, Du J, Zhang D, Han C, Chen Y, Wang C, Zhao Y, 2023
- Class I histone deacetylases (HDAC1-3) are histone lysine delactylases, Moreno-Yruela C, Zhang D, Wei W, Bæk M, Liu W, Gao J, Danková D, Nielsen AL, Bolding JE, Yang L, Jameson ST, Wong J, Olsen CA, Zhao Y, 2022
- The regulatory enzymes and protein substrates for the lysine β-hydroxybutyrylation pathway, Huang H, Zhang D, Weng Y, Delaney K, Tang Z, Yan C, Qi S, Peng C, Cole PA, Roeder RG, Zhao Y, 2021
- Metabolic regulation of gene expression by histone lactylation, Zhang D, Tang Z, Huang H, Zhou G, Cui C, Weng Y, Liu W, Kim S, Lee S, Perez-Neut M, Czyz D, Hu R, Ye Z, He M, Zheng YG, Shuman H, Ding J, Dai L, Ren B, Robert RG, Becker L, Zhao Y, 2019
- Lysine benzoylation is a histone mark regulated by SIRT2, Huang H, Zhang D, Wang Y, Perez-Neut M, Han Z, Zheng YG, Hao Q, Zhao Y, 2018
- Metabolic Regulation of Gene Expression through Differential Histone Acylation, Sabari BR, Zhang D, Allis CD, Zhao Y, 2017
- Metabolic Regulation of Gene Expression by Histone Lysine beta-hydroxybutyrylation, Xie Z, Zhang D, Chung D, Tang Z, Huang H, Dai L, Qi S, Li J, Colak G, Chen Y, Xia C, Peng C, Ruan H, Kirkey M, Wang D, Jensen LM, Kwon OK, Lee S, Pletcher SD, Tan M, Lombard DB, White KP, Zhao H, Li J, Roeder RG, Yang X, Zhao Y, 2016
- Dynamic Competing Histone H4 K5K8 Acetylation and Butyrylation Are Hallmarks of Highly Active Gene Promoters, Goudarzi A, Zhang D, Huang H, Barral S, Kwon OK, Qi S, Tang Z, Buchou T, Vitte AL, He T, Cheng Z, Montellier E, Gaucher J, Curtet S, Debernardi A, Charbonnier G, Puthier D, Petosa C, Panne D, Rousseaux S, Roeder RG, Zhao Y, Khochbin S, 2016
- Nucleation of DNA Repair Factors by FOXA1 Links DNA Demethylation to Transcriptional Pioneering, Zhang Y, Zhang D, Liang J, Yi X, Gui B, Yu W, Sun L, Yang X, Han X, Chen Z, Liu S, Si W, Yan R, Wang Y, Shang Y
Awards
- 22nd Young Teacher Basic Skills Competition First Prize, Excellent Teaching Plan Award, Best Teaching Demonstration Award, Most Popular Teacher Award, Course Ideology and Politics Award, 2023
- Boya Young Scholar, 2022
- Bayer Scholar, 2021
- Yifang Scholar, 2021
