Professor | Zhe Zhang | Asia Growth Partners

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Name	Zhe Zhang
Contact Information	zzhang01 (AT) pku.edu.cn
Language ability	Chinese, English
Province	Beijing

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Name

Zhe Zhang

Contact Information

zzhang01 (AT) pku.edu.cn

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	Peking University
Faculty	Life Sciences
Academic Background & Achievements	2004-2008: Bachelor in Biotechnology, Shandong University 2008-2015: PhD in Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences Doctoral supervisor: Professor Jianping Ding
Work Experience	2015-2019: Postdoctoral Researcher, Rockefeller University, USA 2019-present: Researcher, Peking University - Tsinghua University Center for Life Sciences 2019-present: Researcher, School of Life Sciences, Peking University
Awards	2023: Peking University Teaching Excellence Award 2022: Boehringer Ingelheim Young Researcher Award 2021: Most Popular Teacher 2021: Xueersi BoYa Young Scholar 2020: Bayer Scholar 2019: Yifang Scholar 2018: Blavatnik Regional Finalist for Young Scientists 2018: Tri-Institutional Young Scientist Breakthrough Award 2017-2019: Charles H. Revson Fellowship

University/Lab Affiliation and Title

Peking University

Faculty

Life Sciences

Academic Background & Achievements

2004-2008: Bachelor in Biotechnology, Shandong University
2008-2015: PhD in Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences
Doctoral supervisor: Professor Jianping Ding

Work Experience

2015-2019: Postdoctoral Researcher, Rockefeller University, USA
2019-present: Researcher, Peking University - Tsinghua University Center for Life Sciences
2019-present: Researcher, School of Life Sciences, Peking University

Awards

2023: Peking University Teaching Excellence Award
2022: Boehringer Ingelheim Young Researcher Award
2021: Most Popular Teacher
2021: Xueersi BoYa Young Scholar
2020: Bayer Scholar
2019: Yifang Scholar
2018: Blavatnik Regional Finalist for Young Scientists
2018: Tri-Institutional Young Scientist Breakthrough Award
2017-2019: Charles H. Revson Fellowship

Areas of Focus	Membrane proteins Structural biology Biochemistry Cell biology Electrophysiology
Publications	Structural insights into VAChT neurotransmitter recognition and inhibition, Yang Zhang, Fei Dai, Nanhao Chen, Dong Zhou, Chia-Hsueh Lee, Chen Song, Yixiao Zhang, Zhe Zhang, 2024 Substrates and drug recognition mechanisms of SLC19A3, Yu Dang, Tianyi Zhang, Shabareesh Pidathala, Guopeng Wang, Yijie Wang, Nanhao Chen, Chen Song, Chia-Hsueh Lee, Zhe Zhang, 2024 Mechanisms of neurotransmitter transport and drug inhibition in human VMAT2, Shabareesh Pidathala, Shuyun Liao, Yaxin Dai, Xiao Li, Changkun Long, Chi-Lun Chang, Zhe Zhang, Chia-Hsueh Lee, 2023 Structure and mechanism of a neuropeptide-activated channel in the ENaC/DEG superfamily, Fenglian Liu, Yu Dang, Lu Li, Hao Feng, Jianlin Li, Haowei Wang, Xu Zhang, Zhe Zhang, Sheng Ye, Yutao Tian, Qingfeng Chen, 2023 Structure and dynamics of the EGFR/HER2 heterodimer, Xue Bai, Pengyu Sun, Xinghao Wang, Changkun Long, Shuyun Liao, Song Dang, Shangshang Zhuang, Yongtao Du, Xinyi Zhang, Nan Li, Kangmin He, Zhe Zhang, 2023 Molecular mechanism of substrate recognition by folate transporter SLC19A1, Yu Dang, Dong Zhou, Xiaojuan Du, Hongtu Zhao, Chia-Hsueh Lee, Jing Yang, Yijie Wang, Changdong Qin, Zhenxi Guo, Zhe Zhang, 2022 Specificity of TGF-β1 signal designated by LRRC33 and integrin αVβ8, Zelin Duan, Xuezhen Lin, Lixia Wang, Qiuxin Zhen, Yuefeng Jiang, Chuxin Chen, Jing Yang, Chia-Hsueh Lee, Yan Qin, Ying Li, Bo Zhao, Jianchuan Wang, Zhe Zhang, 2022 Tuning the size of large dense-core vesicles and quantal neurotransmitter release via secretogranin II liquid-liquid phase separation, Zhaohan Lin, Yinglin Li, Yuqi Hang, Changhe Wang, Bing Liu, Jie Li, Lili Yin, Xiaohan Jiang, Xingyu Du, Zhongjun Qiao, Feipeng Zhu, Zhe Zhang, Quanfeng Zhang, Zhuan Zhou, 2022 The NAD+-mediated self-inhibition mechanism of pro-neurodegenerative SARM1, Yuefeng Jiang, Tingting Liu, Chia-Hsueh Lee, Qing Chang, Jing Yang, Zhe Zhang, 2020 Amelioration of hepatic steatosis by dietary essential amino acid-induced ubiquitination, Yansong Zhang, Siyuan Lin, Jingyu Peng, Xiaojuan Liang, Qi Yang, Xue Bai, Yajuan Li, Jinhua Li, Wei Dong, Yue Wang, Ying Huang, Yumeng Pei, Jiabao Guo, Wanni Zhao, Zhe Zhang, Min Liu, Alan Jian Zhu, 2022 Structural insights into the regulation of human serine palmitoyltransferase complexes, Yingdi Wang, Yiming Niu, Zhe Zhang, Kenneth Gable, Sita D Gupta, Niranjanakumari Somashekarappa, Gongshe Han, Hongtu Zhao, Alexander G Myasnikov, Ravi C Kalathur, Teresa M Dunn, Chia-Hsueh Lee, 2021 Structural identification of a hotspot on CFTR for potentiation, Fangyu Liu, Zhe Zhang, Anat Levit, Jesper Levring, Kouki K. Touhara, Brian K. Shoichet, Jue Chen, 2019 Molecular structure of the ATP-bound, phosphorylated human CFTR, Zhe Zhang, Fangyu Liu, Jue Chen, 2018 Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation, Zhe Zhang, Balazs Tóth, Andras Szollosi, Jue Chen, Laszló Csanady, 2018 Conformational changes of CFTR upon phosphorylation and ATP binding, Zhe Zhang, Fangyu Liu, Jue Chen, 2017 Molecular structure of the human CFTR ion channel, Fangyu Liu, Zhe Zhang, Laszló Csanady, David C Gadsby, Jue Chen, 2017 Atomic structure of the cystic fibrosis transmembrane conductance regulator, Zhe Zhang, Jue Chen, 2016 Crystal structure of the Rab9A-RUTBC2 RBD complex reveals the molecular basis for the binding specificity of Rab9A with RUTBC2, Zhe Zhang, Tianlong Zhang, Shanshan Wang, Zhou Gong, Chun Tang, Jiangye Chen, Jianping Ding, 2014 Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5, Zhe Zhang, Tianlong Zhang, Shanshan Wang, Zhou Gong, Chun Tang, Jiangye Chen, Jianping Ding, 2014

Areas of Focus

Membrane proteins
Structural biology
Biochemistry
Cell biology
Electrophysiology

Publications

Structural insights into VAChT neurotransmitter recognition and inhibition, Yang Zhang, Fei Dai, Nanhao Chen, Dong Zhou, Chia-Hsueh Lee, Chen Song, Yixiao Zhang, Zhe Zhang, 2024
Substrates and drug recognition mechanisms of SLC19A3, Yu Dang, Tianyi Zhang, Shabareesh Pidathala, Guopeng Wang, Yijie Wang, Nanhao Chen, Chen Song, Chia-Hsueh Lee, Zhe Zhang, 2024
Mechanisms of neurotransmitter transport and drug inhibition in human VMAT2, Shabareesh Pidathala, Shuyun Liao, Yaxin Dai, Xiao Li, Changkun Long, Chi-Lun Chang, Zhe Zhang, Chia-Hsueh Lee, 2023
Structure and mechanism of a neuropeptide-activated channel in the ENaC/DEG superfamily, Fenglian Liu, Yu Dang, Lu Li, Hao Feng, Jianlin Li, Haowei Wang, Xu Zhang, Zhe Zhang, Sheng Ye, Yutao Tian, Qingfeng Chen, 2023
Structure and dynamics of the EGFR/HER2 heterodimer, Xue Bai, Pengyu Sun, Xinghao Wang, Changkun Long, Shuyun Liao, Song Dang, Shangshang Zhuang, Yongtao Du, Xinyi Zhang, Nan Li, Kangmin He, Zhe Zhang, 2023
Molecular mechanism of substrate recognition by folate transporter SLC19A1, Yu Dang, Dong Zhou, Xiaojuan Du, Hongtu Zhao, Chia-Hsueh Lee, Jing Yang, Yijie Wang, Changdong Qin, Zhenxi Guo, Zhe Zhang, 2022
Specificity of TGF-β1 signal designated by LRRC33 and integrin αVβ8, Zelin Duan, Xuezhen Lin, Lixia Wang, Qiuxin Zhen, Yuefeng Jiang, Chuxin Chen, Jing Yang, Chia-Hsueh Lee, Yan Qin, Ying Li, Bo Zhao, Jianchuan Wang, Zhe Zhang, 2022
Tuning the size of large dense-core vesicles and quantal neurotransmitter release via secretogranin II liquid-liquid phase separation, Zhaohan Lin, Yinglin Li, Yuqi Hang, Changhe Wang, Bing Liu, Jie Li, Lili Yin, Xiaohan Jiang, Xingyu Du, Zhongjun Qiao, Feipeng Zhu, Zhe Zhang, Quanfeng Zhang, Zhuan Zhou, 2022
The NAD+-mediated self-inhibition mechanism of pro-neurodegenerative SARM1, Yuefeng Jiang, Tingting Liu, Chia-Hsueh Lee, Qing Chang, Jing Yang, Zhe Zhang, 2020
Amelioration of hepatic steatosis by dietary essential amino acid-induced ubiquitination, Yansong Zhang, Siyuan Lin, Jingyu Peng, Xiaojuan Liang, Qi Yang, Xue Bai, Yajuan Li, Jinhua Li, Wei Dong, Yue Wang, Ying Huang, Yumeng Pei, Jiabao Guo, Wanni Zhao, Zhe Zhang, Min Liu, Alan Jian Zhu, 2022
Structural insights into the regulation of human serine palmitoyltransferase complexes, Yingdi Wang, Yiming Niu, Zhe Zhang, Kenneth Gable, Sita D Gupta, Niranjanakumari Somashekarappa, Gongshe Han, Hongtu Zhao, Alexander G Myasnikov, Ravi C Kalathur, Teresa M Dunn, Chia-Hsueh Lee, 2021
Structural identification of a hotspot on CFTR for potentiation, Fangyu Liu, Zhe Zhang, Anat Levit, Jesper Levring, Kouki K. Touhara, Brian K. Shoichet, Jue Chen, 2019
Molecular structure of the ATP-bound, phosphorylated human CFTR, Zhe Zhang, Fangyu Liu, Jue Chen, 2018
Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation, Zhe Zhang, Balazs Tóth, Andras Szollosi, Jue Chen, Laszló Csanady, 2018
Conformational changes of CFTR upon phosphorylation and ATP binding, Zhe Zhang, Fangyu Liu, Jue Chen, 2017
Molecular structure of the human CFTR ion channel, Fangyu Liu, Zhe Zhang, Laszló Csanady, David C Gadsby, Jue Chen, 2017
Atomic structure of the cystic fibrosis transmembrane conductance regulator, Zhe Zhang, Jue Chen, 2016
Crystal structure of the Rab9A-RUTBC2 RBD complex reveals the molecular basis for the binding specificity of Rab9A with RUTBC2, Zhe Zhang, Tianlong Zhang, Shanshan Wang, Zhou Gong, Chun Tang, Jiangye Chen, Jianping Ding, 2014
Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5, Zhe Zhang, Tianlong Zhang, Shanshan Wang, Zhou Gong, Chun Tang, Jiangye Chen, Jianping Ding, 2014

Membrane Proteins Structural Biology Biochemistry Cell Biology Electrophysiology Drug Targets Signal Transduction Material Transport Disease-Related Proteins Molecular Mechanisms

Shaojun Dai - Shanghai Normal University

Fang Yu - Shanghai Normal University

Yonglan Cui - Shanghai Normal University

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