Professor | Deqiang Ding | Asia Growth Partners

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Name	Deqiang Ding
Contact Information	dingdeqiang@tongji.edu.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Deqiang Ding

Contact Information

dingdeqiang@tongji.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Tongji University
Faculty	Life Sciences
Academic Background & Achievements	2009 - Bachelor in Biotechnology: Qingdao University 2014 - PhD in Cell Biology: Beijing Normal University Research on telomerase function in cancer development during PhD Selected for Shanghai Overseas High-Level Talent Introduction Plan in 2019 Received National Natural Science Foundation of China Excellent Young Scientist Fund (Overseas) in 2021
Work Experience	2014-2019 - Postdoctoral Researcher, Department of Animal Science, Michigan State University, USA 2019-2022 - Distinguished Research Fellow, School of Life Sciences and Technology, Tongji University 2020-present - Researcher, Tongji University Affiliated Obstetrics and Gynecology Hospital 2022-present - Professor, School of Life Sciences and Technology, Tongji University

University/Lab Affiliation and Title

Tongji University

Faculty

Life Sciences

Academic Background & Achievements

2009 - Bachelor in Biotechnology: Qingdao University
2014 - PhD in Cell Biology: Beijing Normal University
Research on telomerase function in cancer development during PhD
Selected for Shanghai Overseas High-Level Talent Introduction Plan in 2019
Received National Natural Science Foundation of China Excellent Young Scientist Fund (Overseas) in 2021

Work Experience

2014-2019 - Postdoctoral Researcher, Department of Animal Science, Michigan State University, USA
2019-2022 - Distinguished Research Fellow, School of Life Sciences and Technology, Tongji University
2020-present - Researcher, Tongji University Affiliated Obstetrics and Gynecology Hospital
2022-present - Professor, School of Life Sciences and Technology, Tongji University

Areas of Focus	Mechanisms of piRNA generation Function of non-coding RNAs in germ cell development Regulation of transposons in germ cell development Formation and function of membrane-less granule structures in germ cells Pathogenesis of human infertility caused by genetic mutations
Publications	piRNA loading triggers MIWI translocation from the intermitochondrial cement to chromatoid body during mouse spermatogenesis, Wei, H., Gao, J., Lin, D., Geng, R., Liao, J., Huang, T., Shang, G., Jing, J., Fan, Z., Pan, D., Yin, Z., Li, T., Liu, X., Chen, C., Li, J., Wang, X.#, Ding, D.#, and Liu, M.F.#, 2024 MIWI N-terminal RG motif promotes efficient pachytene piRNA production and spermatogenesis independent of LINE1 transposon silencing, Wei, C., Jing, J., Yan, X., Mann, J.M., Geng, R., Xie, H., Demireva, E.Y., Hess, R.A., Ding, D.#, and Chen, C.#, 2023 SYPL1 defines a vesicular pathway essential for sperm cytoplasmic droplet formation and male fertility, Liu, J., Hermo, L., Ding, D., Wei, C., Mann, J.M., Yan, X., Melnick, A.F., Wu, Y., Withrow, A., Cibelli, J., Hess, R.A., and Chen, C.#, 2023 LOTUS domain is a novel class of G-rich and G-quadruplex RNA binding domain, Ding, D., Liu, J., Dong, K., Stanton, A., Xu, C., Min, J., Hu, J., and Chen, C.#, 2020 Mitochondrial membrane-based initial separation of MIWI and MILI functions during pachytene piRNA biogenesis, Ding, D., Liu, J., Dong, K., Melnick, A.F., Latham, K.E., and Chen, C.#, 2019 TDRD5 binds piRNA precursors and selectively enhances pachytene piRNA processing in mice, Ding, D., Liu, J., Dong, K., Midic, U., Hess, R.A., Xie, H., Demireva, E.Y., and Chen, C.#, 2018 PNLDC1 is essential for piRNA 3' end trimming and transposon silencing during spermatogenesis in mice, Ding, D., Liu, J., Dong, K., Midic, U., Hess, R.A., Xie, H., Demireva, E.Y., and Chen, C.#, 2017 hTERT promotes tumor angiogenesis by activating VEGF via interactions with the Sp1 transcription factor, Liu, N., Ding, D., Hao, W., Yang, F., Wu, X., Wang, M., Xu, X., Ju, Z., Liu, J.P., Song, Z., Shay, J. W., Guo, Y., Cong, Y. S.#, 2016 Human telomerase reverse transcriptase regulates MMP expression independently of telomerase activity via NF-kappaB-dependent transcription, Ding, D., Xi, P.*, Zhou, J., Wang, M., and Cong, Y.S.#, 2013

Areas of Focus

Mechanisms of piRNA generation
Function of non-coding RNAs in germ cell development
Regulation of transposons in germ cell development
Formation and function of membrane-less granule structures in germ cells
Pathogenesis of human infertility caused by genetic mutations

Publications

piRNA loading triggers MIWI translocation from the intermitochondrial cement to chromatoid body during mouse spermatogenesis, Wei, H.*, Gao, J.*, Lin, D.*, Geng, R.*, Liao, J., Huang, T., Shang, G., Jing, J., Fan, Z., Pan, D., Yin, Z., Li, T., Liu, X., Chen, C., Li, J., Wang, X.#, Ding, D.#, and Liu, M.F.#, 2024
MIWI N-terminal RG motif promotes efficient pachytene piRNA production and spermatogenesis independent of LINE1 transposon silencing, Wei, C.*, Jing, J.*, Yan, X., Mann, J.M., Geng, R., Xie, H., Demireva, E.Y., Hess, R.A., Ding, D.#, and Chen, C.#, 2023
SYPL1 defines a vesicular pathway essential for sperm cytoplasmic droplet formation and male fertility, Liu, J.*, Hermo, L.*, Ding, D.*, Wei, C., Mann, J.M., Yan, X., Melnick, A.F., Wu, Y., Withrow, A., Cibelli, J., Hess, R.A., and Chen, C.#, 2023
LOTUS domain is a novel class of G-rich and G-quadruplex RNA binding domain, Ding, D.*, Liu, J.*, Dong, K.*, Stanton, A., Xu, C., Min, J., Hu, J., and Chen, C.#, 2020
Mitochondrial membrane-based initial separation of MIWI and MILI functions during pachytene piRNA biogenesis, Ding, D.*, Liu, J.*, Dong, K.*, Melnick, A.F., Latham, K.E., and Chen, C.#, 2019
TDRD5 binds piRNA precursors and selectively enhances pachytene piRNA processing in mice, Ding, D.*, Liu, J.*, Dong, K.*, Midic, U., Hess, R.A., Xie, H., Demireva, E.Y., and Chen, C.#, 2018
PNLDC1 is essential for piRNA 3' end trimming and transposon silencing during spermatogenesis in mice, Ding, D.*, Liu, J.*, Dong, K.*, Midic, U., Hess, R.A., Xie, H., Demireva, E.Y., and Chen, C.#, 2017
hTERT promotes tumor angiogenesis by activating VEGF via interactions with the Sp1 transcription factor, Liu, N.*, Ding, D.*, Hao, W., Yang, F., Wu, X., Wang, M., Xu, X., Ju, Z., Liu, J.P., Song, Z., Shay, J. W., Guo, Y., Cong, Y. S.#, 2016
Human telomerase reverse transcriptase regulates MMP expression independently of telomerase activity via NF-kappaB-dependent transcription, Ding, D.*, Xi, P.*, Zhou, J., Wang, M., and Cong, Y.S.#, 2013

Pirna Non-Coding Rna Germ Cell Transposons Membrane-Less Granules Genetic Mutations Infertility Gene Regulation Biogenesis Molecular Mechanism

Zhang Lin - Shanghai Normal University

Zhang Lin - Shanghai Normal University

Xudong Guo - Tongji University

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