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Zhenning Zhang
Life Science
Tongji University
Shanghai
Language: Chinese, English
Stem Cells
Regeneration
Biology
Disease
Modeling
Translational
Medicine
Neurological
Metabolic
Therapeutics
Areas of Focus
- Stem Cell and Regenerative Biology
- Disease Modeling and Translational Medicine
Work Experience
- 2009-2016 - Postdoctoral Researcher at University of California, San Diego
Academic Background & Achievements
- 2004 - Bachelor in Biotechnology: Jilin University
- 2009 - PhD in Cell Biology: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
- Published 15 papers as first or corresponding author in high-impact journals
- Led 3 national natural science projects and a key national research and development program
Publications
- ISR inhibition reverses pancreatic β-cell failure in Wolfram syndrome models, Hu R, Chen X, Su Q, Wang Z, Wang X, Gong M, Xu M, Le R, Gao Y, Dai P, Zhang ZN, Shao L, Li W, 2024
- Charting a high-resolution roadmap for regeneration of pancreatic β cells by in vivo transdifferentiation from adult acinar cells, Liu G, Li Y, Li M, Li S, He Q, Liu S, Su Q, Chen X, Xu M, Zhang ZN, Shao Z, Li W, 2023
- Modeling disrupted synapse formation in wolfram syndrome using hESCs-derived neural cells and cerebral organoids identifies Riluzole as a therapeutic molecule, Yuan F, Li Y, Hu R, Gong M, Chai M, Ma X, Cha J, Guo P, Yang K, Li M, Xu M, Ma Q, Su Q, Zhang C, Sheng Z, Wu H, Wang Y, Yuan W, Bian S, Shao L, Zhang R, Li K, Shao Z, Zhang ZN, Li W, 2023
- MiniCAFE, a CRISPR/Cas9-based compact and potent transcriptional activator, elicits gene expression in vivo, Zhang X, Lv S, Luo Z, Hu Y, Peng X, Lv J, Zhao S, Feng J, Huang G, Wan QL, Liu J, Huang H, Luan B, Wang D, Zhao X, Lin Y, Zhou Q, Zhang ZN, Rong Z, 2021
- BMAL1 functions as a cAMP-responsive coactivator of HDAC5 to regulate hepatic gluconeogenesis, Li J, Lv S, Qiu X, Yu J, Jiang J, Jin Y, Guo W, Zhao R, Zhang ZN, Zhang C, Luan B, 2018
- HDAC5 integrates ER stress and fasting signals to regulate hepatic fatty acid oxidation, Qiu X, Li J, Lv S, Yu J, Jiang J, Yao J, Xiao Y, Xu B, He H, Guo F, Zhang ZN, Zhang C, Luan B
- Glucagon-induced extracellular cAMP regulates hepatic lipid metabolism, Lv S, Qiu X, Li J, Li W, Zhang C, Zhang ZN, Luan B
- A negative feedback loop of ICER and NF-κB regulates TLR signaling in innate immune responses, Lv S, Li J, Qiu X, Li W, Zhang C, Zhang ZN, Luan B, 2017
- SIK2 regulates fasting-induced PPARα activity and ketogenesis through p300, Zhang ZN, Gong L, Lv S, Li J, Tai X, Cao W, Peng B, Qu S, Li W, Zhang C, Luan B, 2016
- Layered hydrogels accelerate iPSC-derived neuronal maturation and reveal migration defects caused by MeCP2 dysfunction, Zhang ZN, Freitas BC, Qian H, Lux J, Acab A, Trujillo CA, Herai RH, Nguyen Huu VA, Wen JH, Joshi-Barr S, Karpiak JV, Engler AJ, Fu XD, Muotri AR, Almutairi A, 2016
- Suppression of CRTC2-mediated hepatic gluconeogenesis by TRAF6 contributes to hypoglycemia in septic shock, Lv S, Qiu X, Li J, Li W, Zhang C, Zhang ZN, Luan B, 2016
- Humanized Mice Reveal Differential Immunogenicity of Cells Derived from Autologous Induced Pluripotent Stem Cells, Zhao T, Zhang ZN, Westenskow PD, Todorova D, Hu Z, Lin T, Rong Z, Kim J, He J, Wang M, Clegg DO, Yang YG, Zhang K, Friedlander M, Xu Y, 2015
- Oct4 maintains the pluripotency of human embryonic stem cells by inactivating p53 through Sirt1-mediated deacetylation, Zhang ZN, Chung SK, Xu Z, Xu Y
- Facilitation of μ-opioid receptor activity by preventing δ-opioid receptor-mediated codegradation, He SQ, Zhang ZN, Guan JS, Liu HR, Zhao B, Wang HB, Li Q, Yang H, Luo J, Li ZY, Wang Q, Lu YJ, Bao L, Zhang X, 2011
- The voltage-gated Na+ channel Nav1.8 contains an ER-retention/retrieval signal antagonized by the β3 subunit, Zhang ZN, Li Q, Liu C, Wang HB, Wang Q, Bao L, 2008
