Professor | Zhenning Zhang | Asia Growth Partners

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Name	Zhenning Zhang
Contact Information	znzhang@tongji.edu.cn
Language ability	Chinese, English
Province	Shanghai

Upload Avatar (500 x 500)

Name

Zhenning Zhang

Contact Information

znzhang@tongji.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Tongji University
Faculty	Life Sciences
Academic Background & Achievements	2004 - Bachelor in Biotechnology: Jilin University 2009 - PhD in Cell Biology: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences Published 15 papers as first or corresponding author in high-impact journals Led 3 national natural science projects and a key national research and development program
Work Experience	2009-2016 - Postdoctoral Researcher at University of California, San Diego

University/Lab Affiliation and Title

Tongji University

Faculty

Life Sciences

Academic Background & Achievements

2004 - Bachelor in Biotechnology: Jilin University
2009 - PhD in Cell Biology: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
Published 15 papers as first or corresponding author in high-impact journals
Led 3 national natural science projects and a key national research and development program

Work Experience

2009-2016 - Postdoctoral Researcher at University of California, San Diego

Areas of Focus	Stem Cell and Regenerative Biology Disease Modeling and Translational Medicine
Publications	ISR inhibition reverses pancreatic β-cell failure in Wolfram syndrome models, Hu R, Chen X, Su Q, Wang Z, Wang X, Gong M, Xu M, Le R, Gao Y, Dai P, Zhang ZN, Shao L, Li W, 2024 Charting a high-resolution roadmap for regeneration of pancreatic β cells by in vivo transdifferentiation from adult acinar cells, Liu G, Li Y, Li M, Li S, He Q, Liu S, Su Q, Chen X, Xu M, Zhang ZN, Shao Z, Li W, 2023 Modeling disrupted synapse formation in wolfram syndrome using hESCs-derived neural cells and cerebral organoids identifies Riluzole as a therapeutic molecule, Yuan F, Li Y, Hu R, Gong M, Chai M, Ma X, Cha J, Guo P, Yang K, Li M, Xu M, Ma Q, Su Q, Zhang C, Sheng Z, Wu H, Wang Y, Yuan W, Bian S, Shao L, Zhang R, Li K, Shao Z, Zhang ZN, Li W, 2023 MiniCAFE, a CRISPR/Cas9-based compact and potent transcriptional activator, elicits gene expression in vivo, Zhang X, Lv S, Luo Z, Hu Y, Peng X, Lv J, Zhao S, Feng J, Huang G, Wan QL, Liu J, Huang H, Luan B, Wang D, Zhao X, Lin Y, Zhou Q, Zhang ZN, Rong Z, 2021 BMAL1 functions as a cAMP-responsive coactivator of HDAC5 to regulate hepatic gluconeogenesis, Li J, Lv S, Qiu X, Yu J, Jiang J, Jin Y, Guo W, Zhao R, Zhang ZN, Zhang C, Luan B, 2018 HDAC5 integrates ER stress and fasting signals to regulate hepatic fatty acid oxidation, Qiu X, Li J, Lv S, Yu J, Jiang J, Yao J, Xiao Y, Xu B, He H, Guo F, Zhang ZN, Zhang C, Luan B Glucagon-induced extracellular cAMP regulates hepatic lipid metabolism, Lv S, Qiu X, Li J, Li W, Zhang C, Zhang ZN, Luan B A negative feedback loop of ICER and NF-κB regulates TLR signaling in innate immune responses, Lv S, Li J, Qiu X, Li W, Zhang C, Zhang ZN, Luan B, 2017 SIK2 regulates fasting-induced PPARα activity and ketogenesis through p300, Zhang ZN, Gong L, Lv S, Li J, Tai X, Cao W, Peng B, Qu S, Li W, Zhang C, Luan B, 2016 Layered hydrogels accelerate iPSC-derived neuronal maturation and reveal migration defects caused by MeCP2 dysfunction, Zhang ZN, Freitas BC, Qian H, Lux J, Acab A, Trujillo CA, Herai RH, Nguyen Huu VA, Wen JH, Joshi-Barr S, Karpiak JV, Engler AJ, Fu XD, Muotri AR, Almutairi A, 2016 Suppression of CRTC2-mediated hepatic gluconeogenesis by TRAF6 contributes to hypoglycemia in septic shock, Lv S, Qiu X, Li J, Li W, Zhang C, Zhang ZN, Luan B, 2016 Humanized Mice Reveal Differential Immunogenicity of Cells Derived from Autologous Induced Pluripotent Stem Cells, Zhao T, Zhang ZN, Westenskow PD, Todorova D, Hu Z, Lin T, Rong Z, Kim J, He J, Wang M, Clegg DO, Yang YG, Zhang K, Friedlander M, Xu Y, 2015 Oct4 maintains the pluripotency of human embryonic stem cells by inactivating p53 through Sirt1-mediated deacetylation, Zhang ZN, Chung SK, Xu Z, Xu Y Facilitation of μ-opioid receptor activity by preventing δ-opioid receptor-mediated codegradation, He SQ, Zhang ZN, Guan JS, Liu HR, Zhao B, Wang HB, Li Q, Yang H, Luo J, Li ZY, Wang Q, Lu YJ, Bao L, Zhang X, 2011 The voltage-gated Na+ channel Nav1.8 contains an ER-retention/retrieval signal antagonized by the β3 subunit, Zhang ZN, Li Q, Liu C, Wang HB, Wang Q, Bao L, 2008

Areas of Focus

Stem Cell and Regenerative Biology
Disease Modeling and Translational Medicine

Publications

ISR inhibition reverses pancreatic β-cell failure in Wolfram syndrome models, Hu R, Chen X, Su Q, Wang Z, Wang X, Gong M, Xu M, Le R, Gao Y, Dai P, Zhang ZN, Shao L, Li W, 2024
Charting a high-resolution roadmap for regeneration of pancreatic β cells by in vivo transdifferentiation from adult acinar cells, Liu G, Li Y, Li M, Li S, He Q, Liu S, Su Q, Chen X, Xu M, Zhang ZN, Shao Z, Li W, 2023
Modeling disrupted synapse formation in wolfram syndrome using hESCs-derived neural cells and cerebral organoids identifies Riluzole as a therapeutic molecule, Yuan F, Li Y, Hu R, Gong M, Chai M, Ma X, Cha J, Guo P, Yang K, Li M, Xu M, Ma Q, Su Q, Zhang C, Sheng Z, Wu H, Wang Y, Yuan W, Bian S, Shao L, Zhang R, Li K, Shao Z, Zhang ZN, Li W, 2023
MiniCAFE, a CRISPR/Cas9-based compact and potent transcriptional activator, elicits gene expression in vivo, Zhang X, Lv S, Luo Z, Hu Y, Peng X, Lv J, Zhao S, Feng J, Huang G, Wan QL, Liu J, Huang H, Luan B, Wang D, Zhao X, Lin Y, Zhou Q, Zhang ZN, Rong Z, 2021
BMAL1 functions as a cAMP-responsive coactivator of HDAC5 to regulate hepatic gluconeogenesis, Li J, Lv S, Qiu X, Yu J, Jiang J, Jin Y, Guo W, Zhao R, Zhang ZN, Zhang C, Luan B, 2018
HDAC5 integrates ER stress and fasting signals to regulate hepatic fatty acid oxidation, Qiu X, Li J, Lv S, Yu J, Jiang J, Yao J, Xiao Y, Xu B, He H, Guo F, Zhang ZN, Zhang C, Luan B
Glucagon-induced extracellular cAMP regulates hepatic lipid metabolism, Lv S, Qiu X, Li J, Li W, Zhang C, Zhang ZN, Luan B
A negative feedback loop of ICER and NF-κB regulates TLR signaling in innate immune responses, Lv S, Li J, Qiu X, Li W, Zhang C, Zhang ZN, Luan B, 2017
SIK2 regulates fasting-induced PPARα activity and ketogenesis through p300, Zhang ZN, Gong L, Lv S, Li J, Tai X, Cao W, Peng B, Qu S, Li W, Zhang C, Luan B, 2016
Layered hydrogels accelerate iPSC-derived neuronal maturation and reveal migration defects caused by MeCP2 dysfunction, Zhang ZN, Freitas BC, Qian H, Lux J, Acab A, Trujillo CA, Herai RH, Nguyen Huu VA, Wen JH, Joshi-Barr S, Karpiak JV, Engler AJ, Fu XD, Muotri AR, Almutairi A, 2016
Suppression of CRTC2-mediated hepatic gluconeogenesis by TRAF6 contributes to hypoglycemia in septic shock, Lv S, Qiu X, Li J, Li W, Zhang C, Zhang ZN, Luan B, 2016
Humanized Mice Reveal Differential Immunogenicity of Cells Derived from Autologous Induced Pluripotent Stem Cells, Zhao T, Zhang ZN, Westenskow PD, Todorova D, Hu Z, Lin T, Rong Z, Kim J, He J, Wang M, Clegg DO, Yang YG, Zhang K, Friedlander M, Xu Y, 2015
Oct4 maintains the pluripotency of human embryonic stem cells by inactivating p53 through Sirt1-mediated deacetylation, Zhang ZN, Chung SK, Xu Z, Xu Y
Facilitation of μ-opioid receptor activity by preventing δ-opioid receptor-mediated codegradation, He SQ, Zhang ZN, Guan JS, Liu HR, Zhao B, Wang HB, Li Q, Yang H, Luo J, Li ZY, Wang Q, Lu YJ, Bao L, Zhang X, 2011
The voltage-gated Na+ channel Nav1.8 contains an ER-retention/retrieval signal antagonized by the β3 subunit, Zhang ZN, Li Q, Liu C, Wang HB, Wang Q, Bao L, 2008

Stem Cells Regeneration Biology Disease Modeling Translational Medicine Neurological Metabolic Therapeutics

Li Weida - Tongji University

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Zhang Zhenning - Tongji University

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