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Hua Gu
Life Science
Tongji University
Shanghai
Language: Chinese, English
Biopharmaceuticals
Antitumor
Autoimmune Diseases
Drug Development
Molecular Biology
Angiogenesis
Tumor
Vascular
Molecular Regulation
Research
Areas of Focus
- Antitumor and autoimmune disease biopharmaceutical development
- Molecular regulation of tumor angiogenesis
Work Experience
- 2009-2011 - Postdoctoral Research at Louisiana State University Health Sciences Center, USA
- 2011-present - Member of Professor Fang Jianmin's research group at Tongji University
Academic Background & Achievements
- 1997 - Bachelor of Science in Biochemistry from East China University of Science and Technology
- 2002 - Master's degree in Biochemistry and Molecular Biology from Fudan University
- 2009 - PhD in Biomedical Engineering from Tongji University
Publications
- Reversing PD-1 Resistance in B16F10 Cells and Recovering Tumour Immunity Using a COX2 Inhibitor, Hua Gu* and Jianmin Fang*, 2022
- A Novel Anti-B7-H3 × Anti-CD3 Bispecific Antibody with Potent Antitumor Activity, Hua Gu* and Jianmin Fang*, 2022
- Adaptive resistance in tumors to anti-PD-1 therapy through re-immunosuppression by upregulation of GPNMB expression, Hua Gu*, Jianmin Fang *, 2021
- A HER2 target antibody drug conjugate combined with anti-PD-(L)1 treatment eliminates hHER2+ tumors in hPD-1 transgenic mouse model and contributes immune memory formation, Hua Gu*, Jianmin Fang *, 2021
- Suppression of c-Met-Overexpressing Tumors by a Novel c-Met/CD3 Bispecific Antibody, Hua Gu*, Jianmin Fang*, 2020
- Improved recombinant protein production by regulation of transcription and protein transport in Chinese hamster ovary cells, Hua Gu, Jianmin Fang*, 2019
- CD89-mediated recruitment of macrophages via a bispecific antibody enhances anti-tumor efficacy, Hua Gu* , Jianmin Fang*, 2018
- Protein phosphatase-1 inhibitor-2 is a novel memory suppressor, Hua Gu, Angus C Nairn, Ya-Ping Tang, Paul J. Colombo, Houhui Xia, 2015
- cAMP/PKA pathways and S56 phosphorylation are involved in AA/PGE2-induced increases in rNaV1.4 current, Hua Gu*, Yan-Jia Fang, dong-dong Liu, Ping Chen, Yan-Ai Mei*, 2015
- The Rac1 inhibitor NSC23766 suppresses CREB signaling by targeting NMDA receptor function, Hua Gu, Benjamin A.Siddoway, Benjamin J. Hall, Pablo E. Castillo, Houhui Xia, 2014
- Modulation of muscle rNa V1.4 Na+ channel isoform by arachidonic acid and its non-metabolized analog, Hua Gu, Y. J.He, Y. L.Sun, J.Zhu, J.Mei, Y. A., 2009
Awards
- 2020-2021: Advanced Individual in Undergraduate Admissions Work at Tongji University
- 2021: Advanced Individual in Women's Work at Tongji University
- 2019: Model Family Award at Tongji University
- 2019: Third Prize in Teaching Achievement at Tongji University
- 2017: Talent Fund for Female Teachers at Tongji University
- 2017: Second Prize in Teaching Achievement at Tongji University
- 2014: First Prize in Teaching Achievement at Shanghai Municipal Level
- 2014: Advanced Individual in Class Teacher Work at Tongji University
- 2013: Outstanding Contribution Award in Class Teacher Work at Tongji University
- 2012: Third Prize in Young Teacher Teaching Competition at School of Life Science and Technology
- 2009: First Prize in Young Teacher Teaching Competition at School of Life Science and Technology
