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Faxiang Li
Life Science
Central South University
Hunan
Language: Chinese, English
Structural Biology
Biochemistry
Cell Biology
Biomolecular Machines
Human Health
Major Diseases
Protein Structure
Small Molecule Inhibitors
Neurodegenerative Diseases
Heart Diseases
Areas of Focus
- Structural biology, biochemistry, and cell biology to explore the structure and function of biomolecular machines related to human health and major diseases
- Protein structure-based small molecule inhibitor screening and optimization for neurodegenerative diseases and heart diseases
Work Experience
- 2016.1-2017.2 - Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences - Assistant Researcher
- 2017.2-2021.5 - University of Texas Southwestern Medical Center, Department of Pharmacology - Postdoctoral Researcher
- 2021.9-present - Central South University, School of Life Sciences - Distinguished Professor
Academic Background & Achievements
- 2005-2009 Bachelor of Science: Hunan Normal University, School of Life Sciences
- 2009-2012 Master of Science: Hunan Normal University, School of Life Sciences
- 2012-2016 Doctor of Science: Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Publications
- Cryo-EM Structures of Human p97 Double Hexamer Capture Potentiated ATPase-competent State, Haishan Gao, Faxiang Li, Zhejian Ji, Zhubing Shi, Yang Li, Hongtao Yu
- Cryo-EM Structure of VASH1-SVBP Complex Bound to Microtubules, Faxiang Li, Yang Li, Xiang Ye, Haishan Gao, Zhubing Shi, Luo X, Luke M. Rice, Hongtao Yu, 2020
- Structural Basis of Tubulin Detyrosination by Vasohibins, Faxiang Li, Yuhui Hu, Shiqing Qi, Luo X, Hongtao Yu, 2019
- Structural Insight into DNA-dependent Activation of Human Metalloprotease Spartan, Faxiang Li, Joanna Raczynska, Zhen Chen, Hongtao Yu, 2019
- Structural Basis of Ubiquitin Recognition by Autophagy Receptor Optineurin, Faxiang Li, Dongsheng Xu, Jian Liu, Yulong Wang, Xiang Cheng, Yuhui Guo, Yulong Gong, Shuhui Hu, Lian Pan, 2018
- Structural Insights into the Interaction and Disease Mechanism of Neurodegenerative Disease-associated Optineurin and TBK1 proteins, Faxiang Li, Xiang Xie, Yulong Wang, Jian Liu, Xiang Cheng, Yuhui Guo, Yulong Gong, Shuhui Hu, Lian Pan, 2016
- Molecular Basis of Ubiquitin Recognition by Autophagy Receptor CALCOCO2, Xiang Xie, Faxiang Li, Yulong Wang, Zhen Lin, Xiang Cheng, Jian Liu, Chao Chen, Lian Pan, 2015
- Mechanistic Insight into TRIP13-catalyzed Mad2 Structural Transition and Spindle Checkpoint Silencing, Michelle L. Brulotte, Byung-Chul Jeong, Faxiang Li, Bin Li, Edward B. Yu, Qian Wu, C. Andrew Brautigam, Hongtao Yu, Luo X, 2017
- Structural Basis of FYCO1 and MAP1LC3A Interaction Reveals a Novel Binding Mode for Atg8 Family Proteins, Xiang Cheng, Yulong Wang, Yulong Gong, Faxiang Li, Yuhui Guo, Shuhui Hu, Jian Liu, Lian Pan, 2016
