Professor | Faxiang Li | Asia Growth Partners

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Name	Faxiang Li
Contact Information	chinalfx@163.com
Language ability	Chinese, English
Province	Hunan

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Name

Faxiang Li

Contact Information

chinalfx@163.com

Language ability

Chinese, English

Province

Hunan

University/Lab Affiliation and Title	Central South University
Faculty	Life Sciences
Academic Background & Achievements	2005-2009 Bachelor of Science: Hunan Normal University, School of Life Sciences 2009-2012 Master of Science: Hunan Normal University, School of Life Sciences 2012-2016 Doctor of Science: Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Work Experience	2016.1-2017.2 - Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences - Assistant Researcher 2017.2-2021.5 - University of Texas Southwestern Medical Center, Department of Pharmacology - Postdoctoral Researcher 2021.9-present - Central South University, School of Life Sciences - Distinguished Professor

University/Lab Affiliation and Title

Central South University

Faculty

Life Sciences

Academic Background & Achievements

2005-2009 Bachelor of Science: Hunan Normal University, School of Life Sciences
2009-2012 Master of Science: Hunan Normal University, School of Life Sciences
2012-2016 Doctor of Science: Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

Work Experience

2016.1-2017.2 - Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences - Assistant Researcher
2017.2-2021.5 - University of Texas Southwestern Medical Center, Department of Pharmacology - Postdoctoral Researcher
2021.9-present - Central South University, School of Life Sciences - Distinguished Professor

Areas of Focus	Structural biology, biochemistry, and cell biology to explore the structure and function of biomolecular machines related to human health and major diseases Protein structure-based small molecule inhibitor screening and optimization for neurodegenerative diseases and heart diseases
Publications	Cryo-EM Structures of Human p97 Double Hexamer Capture Potentiated ATPase-competent State, Haishan Gao, Faxiang Li, Zhejian Ji, Zhubing Shi, Yang Li, Hongtao Yu Cryo-EM Structure of VASH1-SVBP Complex Bound to Microtubules, Faxiang Li, Yang Li, Xiang Ye, Haishan Gao, Zhubing Shi, Luo X, Luke M. Rice, Hongtao Yu, 2020 Structural Basis of Tubulin Detyrosination by Vasohibins, Faxiang Li, Yuhui Hu, Shiqing Qi, Luo X, Hongtao Yu, 2019 Structural Insight into DNA-dependent Activation of Human Metalloprotease Spartan, Faxiang Li, Joanna Raczynska, Zhen Chen, Hongtao Yu, 2019 Structural Basis of Ubiquitin Recognition by Autophagy Receptor Optineurin, Faxiang Li, Dongsheng Xu, Jian Liu, Yulong Wang, Xiang Cheng, Yuhui Guo, Yulong Gong, Shuhui Hu, Lian Pan, 2018 Structural Insights into the Interaction and Disease Mechanism of Neurodegenerative Disease-associated Optineurin and TBK1 proteins, Faxiang Li, Xiang Xie, Yulong Wang, Jian Liu, Xiang Cheng, Yuhui Guo, Yulong Gong, Shuhui Hu, Lian Pan, 2016 Molecular Basis of Ubiquitin Recognition by Autophagy Receptor CALCOCO2, Xiang Xie, Faxiang Li, Yulong Wang, Zhen Lin, Xiang Cheng, Jian Liu, Chao Chen, Lian Pan, 2015 Mechanistic Insight into TRIP13-catalyzed Mad2 Structural Transition and Spindle Checkpoint Silencing, Michelle L. Brulotte, Byung-Chul Jeong, Faxiang Li, Bin Li, Edward B. Yu, Qian Wu, C. Andrew Brautigam, Hongtao Yu, Luo X, 2017 Structural Basis of FYCO1 and MAP1LC3A Interaction Reveals a Novel Binding Mode for Atg8 Family Proteins, Xiang Cheng, Yulong Wang, Yulong Gong, Faxiang Li, Yuhui Guo, Shuhui Hu, Jian Liu, Lian Pan, 2016

Areas of Focus

Structural biology, biochemistry, and cell biology to explore the structure and function of biomolecular machines related to human health and major diseases
Protein structure-based small molecule inhibitor screening and optimization for neurodegenerative diseases and heart diseases

Publications

Cryo-EM Structures of Human p97 Double Hexamer Capture Potentiated ATPase-competent State, Haishan Gao, Faxiang Li, Zhejian Ji, Zhubing Shi, Yang Li, Hongtao Yu
Cryo-EM Structure of VASH1-SVBP Complex Bound to Microtubules, Faxiang Li, Yang Li, Xiang Ye, Haishan Gao, Zhubing Shi, Luo X, Luke M. Rice, Hongtao Yu, 2020
Structural Basis of Tubulin Detyrosination by Vasohibins, Faxiang Li, Yuhui Hu, Shiqing Qi, Luo X, Hongtao Yu, 2019
Structural Insight into DNA-dependent Activation of Human Metalloprotease Spartan, Faxiang Li, Joanna Raczynska, Zhen Chen, Hongtao Yu, 2019
Structural Basis of Ubiquitin Recognition by Autophagy Receptor Optineurin, Faxiang Li, Dongsheng Xu, Jian Liu, Yulong Wang, Xiang Cheng, Yuhui Guo, Yulong Gong, Shuhui Hu, Lian Pan, 2018
Structural Insights into the Interaction and Disease Mechanism of Neurodegenerative Disease-associated Optineurin and TBK1 proteins, Faxiang Li, Xiang Xie, Yulong Wang, Jian Liu, Xiang Cheng, Yuhui Guo, Yulong Gong, Shuhui Hu, Lian Pan, 2016
Molecular Basis of Ubiquitin Recognition by Autophagy Receptor CALCOCO2, Xiang Xie, Faxiang Li, Yulong Wang, Zhen Lin, Xiang Cheng, Jian Liu, Chao Chen, Lian Pan, 2015
Mechanistic Insight into TRIP13-catalyzed Mad2 Structural Transition and Spindle Checkpoint Silencing, Michelle L. Brulotte, Byung-Chul Jeong, Faxiang Li, Bin Li, Edward B. Yu, Qian Wu, C. Andrew Brautigam, Hongtao Yu, Luo X, 2017
Structural Basis of FYCO1 and MAP1LC3A Interaction Reveals a Novel Binding Mode for Atg8 Family Proteins, Xiang Cheng, Yulong Wang, Yulong Gong, Faxiang Li, Yuhui Guo, Shuhui Hu, Jian Liu, Lian Pan, 2016

Structural Biology Biochemistry Cell Biology Biomolecular Machines Human Health Major Diseases Protein Structure Small Molecule Inhibitors Neurodegenerative Diseases Heart Diseases

Shaojun Dai - Shanghai Normal University

Fang Yu - Shanghai Normal University

Yonglan Cui - Shanghai Normal University

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