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Cheng Shiya
Medical School
Wuhan University
Hubei
Language: Chinese, English
Oogenesis
Embryonic Development
Infertility
Oocytes
Maternal Factors
Mrna
Proteins
Organelles
Mechanisms
Therapeutic Approaches
Areas of Focus
- Oogenesis and early embryonic development
Work Experience
- 2014-2016 - Beijing Institute of Life Sciences - Postdoctoral Researcher
- 2016-2024 - Max Planck Institute for Multidisciplinary Sciences - Postdoctoral Researcher
- 2024-Present - Wuhan University, Taikang Medical College (Basic Medical College) - Professor
- 2024-Present - Wuhan University, Taikang Life Medical Center - PI
Academic Background & Achievements
- 2005-2009 Bachelor: Sichuan University, School of Life Sciences
- 2009-2014 PhD: Peking Union Medical College/Beijing Institute of Life Sciences, Biochemistry and Molecular Biology
Publications
- Translational control of prophase I arrest in mouse oocytes, Cheng, S. and Schuh, M., 2024
- Mammalian oocytes store mRNAs in a mitochondria-associated membraneless compartment, Cheng, S.*, Altmeppen, G.*, So, C., Welp, L.M., Penir, S., Ruhwedel, T., Menelaou, K., Harasimov, K., Stützer, A., Blayney, M., Elder, K., Möbius, W., Urlaub, H., and Schuh, M., 2022
- Mouse oocytes sequester aggregated proteins in degradative super-organelles, Zaffagnini, G., Cheng, S., Salzer, M.C., Pernaute, B., Duran, J.M., Irimia, M., Schuh, M., Böke, E., 2024
- HIV-1 capsids enter the FG phase of nuclear pores like a transport receptor, Fu, L., Weiskopf, E.N., Akkermans, O., Swanson, N.A., Cheng, S., Schwartz, T.U., and Gorlich, D., 2024
- The maintenance of oocytes in the mammalian ovary involves extreme protein longevity, Harasimov, K., Gorry, R.L., Welp, L.M., Penir, S., Horokhovskyi, Y., Cheng, S., Takaoka, K., Stützer, A., Frombach, A., Taylor-Tavares, A.L., Raabe, M., Haag, S., Saha, D., Grewe, K., Schipper, V., Rizzoli, S.O., Urlaub, H., Liepe, J., Schuh, M., 2024
- Phase Separation during Germline Development, So, C.*, Cheng, S.*, and Schuh, M., 2021
- Distinct roles of two myosins in C. elegans spermatid differentiation, Hu, J.*, Cheng, S.*, Wang, H., Li, X., Liu, S., Wu, M., Liu, Y., and Wang, X., 2019
- Dissecting Phagocytic Removal of Apoptotic Cells in Caenorhabditis elegans, Cheng, S., Liu, K., Yang, C., and Wang, X., 2017
- PtdIns(4,5)P2 and PtdIns3P coordinate to regulate phagosomal sealing for apoptotic cell clearance, Cheng, S., Wang, K., Zou, W., Miao, R., Huang, Y., Wang, H., and Wang, X., 2015
- PI3P phosphatase activity is required for autophagosome maturation and autolysosome formation, Wu, Y., Cheng, S., Zhao, H., Zou, W., Yoshina, S., Mitani, S., Zhang, H., and Wang, X., 2014
- Autophagy genes coordinate with the class II PI/PtdIns 3-kinase PIKI-1 to regulate apoptotic cell clearance in C. elegans, Cheng, S., Wu, Y., Lu, Q., Yan, J., Zhang, H., and Wang, X., 2013
- Autophagy activity contributes to programmed cell death in Caenorhabditis elegans, Wang, H., Lu, Q., Cheng, S., Wang, X., and Zhang, H., 2013
- Autophagy genes function sequentially to promote apoptotic cell corpse degradation in the engulfing cell, Li, W., Zou, W., Yang, Y., Chai, Y., Chen, B., Cheng, S., Tian, D., Wang, X., Vale, R.D., and Ou, G., 2012
Awards
- National Talent Project (2023)
- Hubei Province Talent Project (2023)
- EMBO Long-Term Fellowship (2016)
