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Yang Jing
Medical School
Wuhan University
Hubei
Language: Chinese, English
Lipid Metabolism
Cell Membrane
Cancer
Angiogenesis
Metastasis
Arachidonic Acid
Cox
Lox
Cyp Enzymes
Biological Activity
Areas of Focus
- Functional studies of important lipid metabolites in cell membranes
- Innovative drug research and development
Work Experience
- 2007-present: Professor, Deputy Head of Department, Pharmacology Department, Basic Medical College, Wuhan University
- 2002-2006: Associate Professor, Deputy Head of Department, Pharmacology Department, Medical College, Wuhan University
- 2006: Research Training, Pharmacology Department, Fukushima Medical University, Japan
- 1990-1998: Physician, Senior Physician, Clinical Pharmacology Laboratory, Hubei Provincial Institute of Geriatric Medicine
Academic Background & Achievements
- 1998-2001: PhD in Internal Medicine, Wuhan University
- 1987-1990: Master's in Pathogenic Biology, Hubei Medical University
- 1982-1987: Bachelor's in Clinical Medicine, Hubei Medical University
- Published nearly 30 SCI-indexed papers
- High Citation Award from Pharmacol Res journal in 2009
Publications
- CYP4A in tumor-associated macrophages promotes pre-metastatic niche formation and metastasis, Yang J*, 2017
- Inhibition of CYP4A by a novel flavonoid FLA-16 prolongs survival and normalizes tumor vasculature in glioma, Yang J*, 2017
- 20-HETE regulates the angiogenic functions of human endothelial progenitor cells and contributes to angiogenesis in vivo, Yang J*, 2014
- Isoliquiritigenin, a flavonoid from licorice, blocks M2 macrophage polarization in colitis-associated tumorigenesis through downregulating PGE2 and IL-6, Yang J*, 2014
- Downregulation of COX-2 and CYP 4A signaling by isoliquiritigenin inhibits human breast cancer metastasis through preventing anoikis resistance, migration and invasion, Yang J*, 2014
- Isoliquiritigenin induces growth inhibition and apoptosis through downregulating arachidonic acid metabolic network and the deactivation of PI3K/Akt in human breast cancer, Yang J*, 2013
- Increased expression of CYP4Z1 promotes tumor angiogenesis and growth in human breast cancer, Yang J*, 2012
- Antitumor and immunostimulatory activity of a polysaccharide–protein complex from Scolopendra subspinipes mutilans L. Koch in tumor-bearing mice, Yang J*, 2012
- Cytochrome P450 ω-hydroxylase promotes angiogenesis and metastasis by upregulation of VEGF and MMP-9 in non-small cell lung cancer, Yang J*, 2011
- Protective effects of isoliquiritigenin in transient middle cerebral artery occlusion-induced focal cerebral ischemia in rats, Yang J*, 2006
Awards
- 2011: New Drug Certificate and Production Approval for 'Valtrate Extract and Spasmolysis Capsule' (Drug Approval Number: Z20110032)
- Major Scientific and Technological Achievement Award, Wuhan (WK200608010)
