Areas of Focus
- Protein ubiquitination in pathogen infection and host immune function
- Regulatory factors in immune signaling pathways
- Antiviral immune responses
- Ubiquitin ligases in antiviral and disease resistance
Work Experience
- 2012/03-Present, Wuhan University, Department of Biochemistry and Molecular Biology, Associate Professor
- 2018/08-2020/07, University of Texas Southwestern Medical Center, Department of Molecular Biology, Visiting Scholar
- 2007/06-2012/01, University of California, San Francisco, Department of Medicine and Gastroenterology, Postdoctoral Researcher
Academic Background & Achievements
- 2000/09-2006/05, PhD in Biochemistry and Molecular Biology, Johns Hopkins University, School of Public Health
- 1997/09-2000/07, Master in Biochemistry and Molecular Biology, Peking University, School of Life Sciences
- 1993/09-1997/07, Bachelor in Biotechnology, Peking University, School of Life Sciences
Publications
- Suppression of HIV-1 Integration by Targeting HIV-1 Integrase for Degradation with A Chimeric Ubiquitin Ligase, Zhang Z, Yuan S, Xu S, Guo D, Chen L, Hou W, Wang M, 2020
- ABIN1 inhibits HDAC1 ubiquitination and protects HDAC1 from both proteasome- and lysozyme-dependent degradation, Ma Y, Yuan S, Tian X, Lin S, Hu T, Wei S, Chen S, Li X, Chen S, Wu D, Wang M, Guo D, 2018
- The N-terminal ubiquitin-associated domain of Cezanne is crucial for its function to suppress NF-κB pathway, Ji Y, Cao L, Zeng L, Zhang Z, Xiao Q, Guan P, Chen S, Chen Y, Wang M, Guo D, 2018
- Immune regulator ABIN1 suppresses HIV-1 transcription by negatively regulating the ubiquitination of Tat, Chen S, Yang X, Cheng W, Ma Y, Shang Y, Cao L, Chen S, Chen Y, Wang M, Guo D, 2017
- Severe acute respiratory syndrome coronavirus protein 6 mediates ubiquitin-dependent proteosomal degradation of N-Myc (and STAT) interactor, Cheng W, Chen S, Li R, Chen Y, Wang M, Guo D, 2015
Awards
- 2013, Selected for the 6th '3551 Optics Valley Talent Plan' in Wuhan East Lake High-tech Zone
- 2016, Third Prize in Young Teaching Competition, School of Basic Medicine, Wuhan University