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Lianrong Wang
Medical School
Wuhan University
Hubei
Language: English, Chinese
Dna Modification
Phosphorothioate
Synthetic Biology
Defense Systems
Gene Expression
Oxidative-Reduction Balance
Antiphage Engineering
Pathogenic Bacteria
Drug Resistance
Phage Therapy
Areas of Focus
- Genomic phosphorothioate modification and synthetic biology
- Epigenetic and biomedical applications
Work Experience
- 2011-Present Professor, School of Pharmacy, Wuhan University
- 2008-2011 Postdoctoral Researcher, Department of Biological Engineering, MIT
- 2006-2008 Visiting PhD Student, Department of Biological Engineering, MIT
Academic Background & Achievements
- 2003-2008 PhD, Shanghai Jiao Tong University, School of Life Sciences
- 1999-2003 Bachelor, Shandong University, School of Life Sciences
Publications
- SspABCD-SspE is a phosphorothioation-sensing bacterial defense system with broad antiphage activities, Lianrong Wang*, 2020
- The functional coupling between restriction and DNA phosphorothioate modification systems underlying the DndFGH restriction complex, Lianrong Wang*, 2022
- Epigenetic Competition Reveals Density-Dependent Regulation and Target Site Plasticity of Phosphorothioate Epigenetics in Bacteria, Lianrong Wang*, 2020
- Systematic strategies for developing phage resistant Escherichia coli strains, Lianrong Wang*, 2022
- Nicking mechanism underlying the DNA phosphorothioate-sensing antiphage defense by SspE, Lianrong Wang*, 2022
- Engineered Phage with Aggregation-Induced Emission Photosensitizer in Cocktail Therapy against Sepsis, Lianrong Wang*
- A Membrane-Targeted Photosensitizer Prevents Drug Resistance and Induces Immune Response in Treating Candidiasis, Lianrong Wang*, 2023
- Single-molecule optical mapping of the distribution of DNA phosphorothioate epigenetics, Lianrong Wang*, 2021
- A Membrane-Targeting Photosensitizer with Aggregation-Induced Emission Characteristics for Highly Efficient Photodynamic Combat of Human Coronaviruses, Lianrong Wang*, 2021
- Genomic mapping of phosphorothioates reveals partial modification of short consensus sequences, Lianrong Wang*, 2014
- C9orf72 regulates the unfolded protein response and stress granule formation by interacting with eIF2α, Lianrong Wang*, 2022
- Involvement of the DNA Phosphorothioation System in TorR Binding and Anaerobic TMAO Respiration in Salmonella enterica, Lianrong Wang*, 2022
- Structural and Functional Analysis of DndE Involved in DNA Phosphorothioation in the Haloalkaliphilic Archaea Natronorubrum bangense JCM10635, Lianrong Wang*, 2022
- Gut microbiome interventions in human health and diseases, Lianrong Wang*, 2019
- Pathological convergence of APP and SNCA deficiency in hippocampal degeneration of young rats, Lianrong Wang*, 2023
- Aggregation-induced emission: recent applications in infectious diseases, Lianrong Wang*, 2023
- Phosphorothioation of DNA in bacteria by dnd genes, Lianrong Wang*, 2007
- DNA phosphorothioation is widespread and quantized in bacterial genomes, Lianrong Wang*, 2011
Awards
- 2023 Chinese Young Female Scientist Award
- 2022 Chief Scientist of Key Projects of the Ministry of Science and Technology
- 2021 National Science Foundation for Distinguished Young Scholars
- 2021 Outstanding Young Faculty of Wuhan University
- 2018 Zhu Yubi Medical Award of Wuhan University
- 2016 Outstanding Medical Contribution Award of Wuhan University
- 2015 Young Top-notch Talent of the Organization Department
- 2015 First Prize in Natural Science of the Higher Education Outstanding Research Achievement Awards (3)
- 2014 Outstanding Medical Contribution Award of Wuhan University
- 2012 National Science Foundation for Excellent Young Scholars
- 2011 New Century Excellent Talents in University
- 2010 National Excellent Doctoral Dissertation
- 2009 Young Investigator of Bioanalysis
- 2009 Shanghai Excellent Doctoral Dissertation
- 2007 Top Ten Scientific News of Global Science
- 2007 Meiji Dairy Life Science Award
