1999.03 - 2003.06 PhD in Chemical Biology, University of St Andrews, UK
1988.09 - 1991.06 Master in Biochemistry, Sichuan University, China
2022.01 - Present: Second-level Professor at School of Pharmaceutical Sciences, Wuhan University
2012.02 - 2021.12: Professor of Molecular Medicine, University of East Anglia, UK
2008.09 - 2012.02: Postdoctoral Researcher supported by Wellcome Trust, University of St Andrews, UK
2007.01 - 2008.09: Eastchem Postdoctoral Researcher, University of St Andrews, UK
2004.04 - 2007.01: Senior Postdoctoral Researcher, University of St Andrews, UK
2002.03 - 2004.04: Postdoctoral Researcher, University of St Andrews, UK
1998.09 - 2002.03: Research Assistant, Boston University, USA
2003.06 - 1998.09: Lecturer, Sichuan University, China
1991.07 - 2003.06: Assistant Lecturer, Sichuan University, China
Times Magazine University Project of the Year Award (2015)
Wellcome Trust Senior Award (2015)
Wellcome Trust Development Award (2008)
Overseas Student Scholarship (1999-2002)
University of St Andrews Scholarship (1999-2002)
Research
Analysis of the structure and function of drug targets, binding of drugs to targets, drug design, and the molecular mechanism of action of protein machinery
Structural basis for bacterial lipoprotein relocation by the transporter LolCDE, Tang X, Chang S, Zhang K, Luo Q, Zhang Z, Wang T, Qiao W, Wang C, Shen C, Zhang Z, Zhu X, Wei X, Dong C, Zhang X, Dong H, 2021
Structural insights into outer membrane asymmetry maintenance in Gram-negative bacteria by MlaFEDB, Tang X, Chang S, Qiao W, Luo Q, Chen Y, Jia Z, Coleman J, Zhang K, Wang T, Zhang Z, Zhang C, Zhu X, Wei X, Dong C, Zhang X, Dong H, 2020
Blocking interaction between SHP2 and PD-1 denotes a novel opportunity for developing PD-1 inhibitors, Fan Z, Tian Y, Chen Z, Liu L, Zhou Q, He J, Coleman J, Dong C, Li N, Huang J, Xu C, Zhang Z, Gao S, Zhou P, Ding K, Chen L, 2020
Cryo-EM structures of lipopolysaccharide transporter LptB2FGC in lipopolysaccharide or AMP-PNP-bound states reveal its transport mechanism, Tang X, Chang S, Luo Q, Zhang Z, Qiao W, Xu C, Zhang C, Niu Y, Yang W, Wang T, Zhang Z, Zhu X, Wei X, Dong C, Zhang X, Dong H, 2019
Structural basis for the role of serine-rich repeat proteins from Lactobacillus reuteri in gut microbe-host interactions, Sequeira S, Kavanaugh D, MacKenzie DA, Šuligoj T, Walpole S, Leclaire C, Gunning AP, Latousakis D, Willats WGT, Angulo J, Dong C, Juge N, 2018
Structural and functional insights into the lipopolysaccharide ABC transporter LptB2FG, Dong H, Zhang Z, Tang X, Paterson NG, Dong C, 2017
Structural basis of outer membrane protein insertion by the BAM complex, Gu Y, Li H, Dong H, Zeng Y, Zhang Z, Paterson NG, Stansfeld PJ, Wang Z, Zhang Y, Wang W, Dong C, 2016
Structural basis for outer membrane lipopolysaccharide insertion, Dong H, Xiang Q, Gu Y, Wang Z, Paterson NG, Stansfeld PJ, He C, Zhang Y, Wang W, Dong C, 2014
Cap binding and immune evasion revealed by Lassa nucleoprotein structure, Qi X, Lan S, Wang W, Schelde LM, Dong H, Ly H, Liang Y, Dong C, 2010
The structure of an open form of an E. coli mechanosensitive channel at 3.45 A resolution, Wang W, Black SS, Edwards MD, Miller S, Morrison EL, Bartlett W, Dong C, Naismith JH, Booth IR, 2008
Wza the translocon for E.coli capsular polysaccharides defines a new class of membrane protein, Dong C, Beis K, Nesper J, Brunkan-Lamontagne AL, Clarke BR, Whitfield C, Naismith JH, 2006
Tryptophan 7-halogenase (PrnA) structure suggests a mechanism for regioselective chlorination, Dong C, Flecks S, Unversucht S, Haupt C, van Pee KH, Naismith JH, 2005
Crystal structure and mechanism of a bacterial fluorinating enzyme, Dong C, Huang F, Deng H, Schaffrath C, Spencer JB, O'Hagan D, Naismith JH, 2004
SUMO protease SENP1 induces isomerization of the scissile peptide bond, Shen L, Tatham MH, Dong C, Zagorska A, Naismith JH, Hay RT, 2006
The 3-D structure of a novel periplasm-spanning platform required for assembly of group 1 capsular polysaccharides in Escherichia coli, Collins R, Beis K, Dong C, Botting C, McDonnel C, Ford R, Clarke B, Whitfield C, Naismith J, 2007
Structural basis of NEDD8 ubiquitin discrimination by the deNEDDylating enzyme NEDP1, Shen LN, Liu H, Dong C, Xirodimas D, Naismith JH, Hay RT, 2005
Lipopolysaccharide is Inserted into the Outer Membrane through An Intramembrane Hole, A Lumen Gate, and the Lateral Opening of LptD, Gu Y, Stansfeld PJ, Zeng Y, Dong H, Wang W, Dong C, 2015
Trapped lipopolysaccharide and LptD intermediates reveal lipopolysaccharide translocation steps across the Escherichia coli outer membrane, Li X, Gu Y, Dong H, Wang W, Dong C, 2015
In vitro and in vivo characterizations of pichinde viral nucleoprotein exoribonuclease functions, Huang Q, Shao J, Lan S, Zhou Y, Xing J, Dong C, Liang Y, Ly H, 2015
Structure of Schmallenberg orthobunyavirus nucleoprotein suggests a novel mechanism of genome encapsidation, Dong H, Li P, Elliott RM, Dong C, 2013
New insights into the mechanism of enzymatic chlorination of tryptophan, Flecks S, Patallo EP, Zhu X, Ernyei AJ, Seifert G, Schneider A, Dong C, Naismith JH, van Pee KH, 2008
Structure and functional analysis of LptC, a conserved membrane protein involved in the lipopolysaccharide export pathway in Escherichia coli, Tran AX, Dong C, Whitfield C, 2010
High-resolution structure of the N-terminal endonuclease domain of the Lassa virus L polymerase in complex with magnesium ions, Wallat GD, Huang Q, Wang W, Dong H, Ly H, Liang Y, Dong C, 2014
The structural basis of chain length control in Rv1086, Wang W, Dong C, McNeil M, Kaur D, Mahapatra S, Crick DC, Naismith JH, 2008
RmlC, a C3' and C5' carbohydrate epimerase, appears to operate via an intermediate with an unusual twist boat conformation, Dong C, Major LL, Srikannathasan V, Errey JC, Philp D, Asuncion M, Giraud MF, Lam J, Graninger M, Messner P, McNeil MR, Field RA, Whitfield C, Naismith JH, 2007
Biological halogenation has moved far beyond haloperoxidases, Van Pee KH, Dong C, Flecks S, Naismith J, Patallo EP, Wage T, 2006
The structure of SENP1 SUMO-2 co-complex suggests a structural basis for discrimination between SUM
