Professor | Tiangang Liu | Asia Growth Partners

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Name	Tiangang Liu
Contact Information	liutg@whu.edu.cn
Language ability	English, Chinese
Province	Hubei

Upload Avatar (500 x 500)

Name

Tiangang Liu

Contact Information

liutg@whu.edu.cn

Language ability

English, Chinese

Province

Hubei

University/Lab Affiliation and Title	Wuhan University
Faculty	Medical School
Academic Background & Achievements	2002 - 2008 PhD: School of Life Sciences and Technology, Shanghai Jiao Tong University 2006 - 2007 Joint PhD Training: Department of Chemistry, Brown University, USA 1998 - 2002 Bachelor: School of Life Sciences, Shandong University
Work Experience	2021 - Present: Wuhan University, School of Pharmacy, Professor Level 2, Doctoral Supervisor 2015 - 2021: Wuhan University, School of Pharmacy, Professor Level 3, Doctoral Supervisor 2012 - Present: Director, Hubei Provincial Engineering Laboratory of Synthetic Microbiology 2012 - Present: Deputy Chief Engineer, Wuhan Institute of Biotechnology 2010 - 2015: Wuhan University, School of Pharmacy, Professor Level 4, Doctoral Supervisor 2008 - 2010: Postdoctoral Researcher, Department of Chemistry, Stanford University, USA
Awards	2020: Young Science and Technology Innovation Leader by the Ministry of Science and Technology of China; Fourth Hubei Province Outstanding Returned Overseas Chinese; Top Ten Scientific Research Figures in COVID-19 Epidemic Prevention 2019: First Prize in Science and Technology Progress of Hubei Province; Top Ten Scientific Events of Hubei Province 2018; Advanced Individual in Natural Science Research of Wuhan University 2017-2018 2018: New Century Excellent Talents of Hubei Province 2017: Special Allowance of the Hubei Provincial Government; Outstanding Youth Fund of Hubei Province 2016: Wuhan Outstanding Young Science and Technology Worker; Second Prize of Hubei Province Natural Science Excellent Academic Paper 2014: Wuhan University Medical Outstanding Contribution Award; Zhu Yubi Medical Prize of Wuhan University

University/Lab Affiliation and Title

Wuhan University

Faculty

Medical School

Academic Background & Achievements

2002 - 2008 PhD: School of Life Sciences and Technology, Shanghai Jiao Tong University
2006 - 2007 Joint PhD Training: Department of Chemistry, Brown University, USA
1998 - 2002 Bachelor: School of Life Sciences, Shandong University

Work Experience

2021 - Present: Wuhan University, School of Pharmacy, Professor Level 2, Doctoral Supervisor
2015 - 2021: Wuhan University, School of Pharmacy, Professor Level 3, Doctoral Supervisor
2012 - Present: Director, Hubei Provincial Engineering Laboratory of Synthetic Microbiology
2012 - Present: Deputy Chief Engineer, Wuhan Institute of Biotechnology
2010 - 2015: Wuhan University, School of Pharmacy, Professor Level 4, Doctoral Supervisor
2008 - 2010: Postdoctoral Researcher, Department of Chemistry, Stanford University, USA

Awards

2020: Young Science and Technology Innovation Leader by the Ministry of Science and Technology of China; Fourth Hubei Province Outstanding Returned Overseas Chinese; Top Ten Scientific Research Figures in COVID-19 Epidemic Prevention
2019: First Prize in Science and Technology Progress of Hubei Province; Top Ten Scientific Events of Hubei Province 2018; Advanced Individual in Natural Science Research of Wuhan University 2017-2018
2018: New Century Excellent Talents of Hubei Province
2017: Special Allowance of the Hubei Provincial Government; Outstanding Youth Fund of Hubei Province
2016: Wuhan Outstanding Young Science and Technology Worker; Second Prize of Hubei Province Natural Science Excellent Academic Paper
2014: Wuhan University Medical Outstanding Contribution Award; Zhu Yubi Medical Prize of Wuhan University

Areas of Focus	Synthetic Biology Metabolic Engineering Efficient Synthesis of Microbial Pharmaceuticals High-throughput Mining of Microbial Natural Products
Publications	Discovery of no-squalene triterpenes, Tao H, Lauterbach L, Bian G, Chen R, Hou A, Mori T, Cheng S, Hu B, Lu L, Mu X, Li M, Adachi N, Kawasaki M, Moriya T, Senda T, Wang X, Deng Z, Abe I, Dickschat J, Liu T, 2022 Efficient exploration of terpenoid biosynthetic gene cluster in filamentous fungi, Yuan Y, Cheng S, Bian G, Yan P, Ma Z, Dai W, Chen R, Fu S, Huang H, Chi H, Cai Y, Deng Z, Liu T, 2022 3β-Hydroxysteroid dehydrogenase expressed by gut microbes degrades testosterone and is linked to depression in males, Li D, Liu R, Wang M, Peng R, Fu S, Fu A, Le J, Yao Q, Yuan T, Chi H, Mu X, Sun T, Liu H, Yan P, Wang S, Cheng S, Deng Z, Liu Z, Wang G, Li Y, Liu T, 2022 Systematic identification of Ocimum sanctum sesquiterpenoid synthases and (-)-eremophilene overproduction in engineered yeast, Deng X, Shi B, Ye Z, Huang M, Chen R, Cai Y, Kuang Z, Sun X, Bian G, Deng Z, Liu T, 2022 Systematic mining of fungal chimeric terpene synthases using an efficient precursor-providing yeast chassis, Chen R, Jia Q, Mu X, Hu B, Sun X, Deng Z, Chen F, Bian G, Liu T, 2021 The concordance between the evolutionary trend and the clinical manifestation of the two SARS-CoV-2 variants, Hu B, Liu R, Tang X, Pan Y, Wang M, Tong Y, Ye G, Shen G, Ying R, Fu A, Li D, Zhao W, Peng J, Guo J, Men D, Yao X, Wang Y, Zhang H, Feng Z, Yu J, Chen L, Deng Z, Lu X, Zhang Y, Li Y, Liu B, Yu L, Li Y, Lu J, Liu T, 2021 Increasing the heterologous production of spinosad in Streptomyces albus J1074 by regulating biosynthesis of its polyketide skeleton, An Z, Tao H, Wang Y, Xia B, Zou Y, Fu S, Fang F, Sun X, Huang R, Xia Y, Deng Z, Liu R, Liu T, 2021 Qualitative analysis of chemical components in LianhuaQingwen capsule by HPLC-Q Exactive-Orbitrap-MS coupled with GC-MS, Fu S, Cheng R, Deng Z, Liu T, 2021 Discovery of the cryptic function of terpene cyclases as aromatic prenyltransferases, He H, Bian G, Herbst-Gervasoni C, Mori T, Shinsky S, Hou A, Mu X, Huang M, Cheng S, Deng Z, Christianson D, Abe I, Liu T, 2020 A cell-free platform based on nisin biosynthesis for discovering novel lanthipeptides and guiding their overproduction in vivo, Liu R, Zhang Y, Zhai G, Fu S, Xia Y, Hu B, Cai X, Zhang Y, Li Y, Deng Z, Liu T, 2020 Nanopore targeted sequencing for the accurate and comprehensive detection of SARS-CoV-2 and other respiratory viruses, Wang M, Fu A, Hu B, Tong Y, Liu R, Liu Z, Gu J, Xiang B, Liu J, Jiang W, Shen G, Zhao W, Men D, Deng Z, Yu L, Wei W, Li Y, Liu T, 2020 Semisynthesis of plant-derived englerin A enabled by microbe engineering of guaia-6, 10 (14)-diene as building block, Siemon T, Wang Z, Bian G, Seitz T, Ye Z, Lu Y, Liu T, Mathias C, 2020 Modular enzyme assembly for enhanced cascade biocatalysis and metabolic flux, Kang W, Ma T, Liu M, Qu Z, Liu Z, Zhang H, Shi B, Fu S, Ma J, Lai L, He S, Qu J, Au S, Kang B, Lau W, Deng Z, Xia J, Liu T, 2019 Systematic metabolic engineering of saccharomyces cerevisiae for lycopene overproduction, Shi B, Ma T, Ye Z, Li X, Huang Y, Zhou Z, Ding Y, Deng Z, Liu T, 2019 Lipid engineering combined with systematic metabolic engineering of Saccharomyces cerevisiae for high-yield production of lycopene, Ma T, Shi B, Ye Z, Li X, Liu M, Chen Y, Xia J, Jens N, Deng ZX, Liu T, 2019 A Clade II-D Fungal Chimeric Diterpene Synthase from Colletotrichum gloeosporioides Making Dolasta-1(15), 8-diene, Bian G, Rinkel J, Wang Z, Lauterbach L, Hou A, Yuan Y, Deng Z, Liu T, Dickschat JS, 2018 Comparative Studies of Glycolytic Pathways and Channeling Under in Vitro and in Vivo Modes, Mary A, Zhang Y, Whitney H, Wang G, Baidoo E, Liu T, Tang Y, 2018 Streptomyces species: Ideal chassis for natural product discovery and over production, Liu R, Deng Z, Liu T, 2018 Modification of E-Poly-L-Lysine In Vivo to Reduce Self-Toxicity and Enhance Antibiotic Overproduction, Ding J, Liang H, Fu S, Liu R, Deng Z, Liu T, 2018 Metabolic engineering-based rapid characterization of a sesquiterpene cyclase and the skeletons of fusariumdiene and fusagramineol from Fusarium graminearum, Bian G, Hou A, Yuan Y, Hu B, Cheng S, Ye Z, Di Y, Deng Z, Liu T, 2018 Strategies for terpenoid overproduction and new terpenoid discovery, Bian G, Deng Z, Liu T

Areas of Focus

Synthetic Biology
Metabolic Engineering
Efficient Synthesis of Microbial Pharmaceuticals
High-throughput Mining of Microbial Natural Products

Publications

Discovery of no-squalene triterpenes, Tao H, Lauterbach L, Bian G, Chen R, Hou A, Mori T, Cheng S, Hu B, Lu L, Mu X, Li M, Adachi N, Kawasaki M, Moriya T, Senda T, Wang X, Deng Z, Abe I, Dickschat J, Liu T, 2022
Efficient exploration of terpenoid biosynthetic gene cluster in filamentous fungi, Yuan Y, Cheng S, Bian G, Yan P, Ma Z, Dai W, Chen R, Fu S, Huang H, Chi H, Cai Y, Deng Z, Liu T, 2022
3β-Hydroxysteroid dehydrogenase expressed by gut microbes degrades testosterone and is linked to depression in males, Li D, Liu R, Wang M, Peng R, Fu S, Fu A, Le J, Yao Q, Yuan T, Chi H, Mu X, Sun T, Liu H, Yan P, Wang S, Cheng S, Deng Z, Liu Z, Wang G, Li Y, Liu T, 2022
Systematic identification of Ocimum sanctum sesquiterpenoid synthases and (-)-eremophilene overproduction in engineered yeast, Deng X, Shi B, Ye Z, Huang M, Chen R, Cai Y, Kuang Z, Sun X, Bian G, Deng Z, Liu T, 2022
Systematic mining of fungal chimeric terpene synthases using an efficient precursor-providing yeast chassis, Chen R, Jia Q, Mu X, Hu B, Sun X, Deng Z, Chen F, Bian G, Liu T, 2021
The concordance between the evolutionary trend and the clinical manifestation of the two SARS-CoV-2 variants, Hu B, Liu R, Tang X, Pan Y, Wang M, Tong Y, Ye G, Shen G, Ying R, Fu A, Li D, Zhao W, Peng J, Guo J, Men D, Yao X, Wang Y, Zhang H, Feng Z, Yu J, Chen L, Deng Z, Lu X, Zhang Y, Li Y, Liu B, Yu L, Li Y, Lu J, Liu T, 2021
Increasing the heterologous production of spinosad in Streptomyces albus J1074 by regulating biosynthesis of its polyketide skeleton, An Z, Tao H, Wang Y, Xia B, Zou Y, Fu S, Fang F, Sun X, Huang R, Xia Y, Deng Z, Liu R, Liu T, 2021
Qualitative analysis of chemical components in LianhuaQingwen capsule by HPLC-Q Exactive-Orbitrap-MS coupled with GC-MS, Fu S, Cheng R, Deng Z, Liu T, 2021
Discovery of the cryptic function of terpene cyclases as aromatic prenyltransferases, He H, Bian G, Herbst-Gervasoni C, Mori T, Shinsky S, Hou A, Mu X, Huang M, Cheng S, Deng Z, Christianson D, Abe I, Liu T, 2020
A cell-free platform based on nisin biosynthesis for discovering novel lanthipeptides and guiding their overproduction in vivo, Liu R, Zhang Y, Zhai G, Fu S, Xia Y, Hu B, Cai X, Zhang Y, Li Y, Deng Z, Liu T, 2020
Nanopore targeted sequencing for the accurate and comprehensive detection of SARS-CoV-2 and other respiratory viruses, Wang M, Fu A, Hu B, Tong Y, Liu R, Liu Z, Gu J, Xiang B, Liu J, Jiang W, Shen G, Zhao W, Men D, Deng Z, Yu L, Wei W, Li Y, Liu T, 2020
Semisynthesis of plant-derived englerin A enabled by microbe engineering of guaia-6, 10 (14)-diene as building block, Siemon T, Wang Z, Bian G, Seitz T, Ye Z, Lu Y, Liu T, Mathias C, 2020
Modular enzyme assembly for enhanced cascade biocatalysis and metabolic flux, Kang W, Ma T, Liu M, Qu Z, Liu Z, Zhang H, Shi B, Fu S, Ma J, Lai L, He S, Qu J, Au S, Kang B, Lau W, Deng Z, Xia J, Liu T, 2019
Systematic metabolic engineering of saccharomyces cerevisiae for lycopene overproduction, Shi B, Ma T, Ye Z, Li X, Huang Y, Zhou Z, Ding Y, Deng Z, Liu T, 2019
Lipid engineering combined with systematic metabolic engineering of Saccharomyces cerevisiae for high-yield production of lycopene, Ma T, Shi B, Ye Z, Li X, Liu M, Chen Y, Xia J, Jens N, Deng ZX, Liu T, 2019
A Clade II-D Fungal Chimeric Diterpene Synthase from Colletotrichum gloeosporioides Making Dolasta-1(15), 8-diene, Bian G, Rinkel J, Wang Z, Lauterbach L, Hou A, Yuan Y, Deng Z, Liu T, Dickschat JS, 2018
Comparative Studies of Glycolytic Pathways and Channeling Under in Vitro and in Vivo Modes, Mary A, Zhang Y, Whitney H, Wang G, Baidoo E, Liu T, Tang Y, 2018
Streptomyces species: Ideal chassis for natural product discovery and over production, Liu R, Deng Z, Liu T, 2018
Modification of E-Poly-L-Lysine In Vivo to Reduce Self-Toxicity and Enhance Antibiotic Overproduction, Ding J, Liang H, Fu S, Liu R, Deng Z, Liu T, 2018
Metabolic engineering-based rapid characterization of a sesquiterpene cyclase and the skeletons of fusariumdiene and fusagramineol from Fusarium graminearum, Bian G, Hou A, Yuan Y, Hu B, Cheng S, Ye Z, Di Y, Deng Z, Liu T, 2018
Strategies for terpenoid overproduction and new terpenoid discovery, Bian G, Deng Z, Liu T

Synthetic Biology Metabolic Pathways Antibiotics Vitamins Natural Products Rare Drugs Drug Precursors High-Throughput Screening Microbial Engineering Biosynthesis

Zixin Deng - Wuhan University

Zhengyan Guo - University of Chinese Academy of Sciences

Li Qi - University of Chinese Academy of Sciences

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