Professor | Zhen-Guo Ma | Asia Growth Partners

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Name	Zhen-Guo Ma
Contact Information	zhengma@whu.edu.cn
Language ability	English, Chinese
Province	Hubei

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Name

Zhen-Guo Ma

Contact Information

zhengma@whu.edu.cn

Language ability

English, Chinese

Province

Hubei

University/Lab Affiliation and Title	Wuhan University
Faculty	Medical School
Academic Background & Achievements	2008-2016: Clinical Medicine (Bachelor to PhD) at Wuhan University Hosted 3 projects from the National Natural Science Foundation Selected as Hubei Province Top Young Talent
Work Experience	2016.07-2016.11 - Wuhan University Renmin Hospital, Resident Physician in Cardiology 2016.12-2018.11 - Wuhan University Renmin Hospital, Attending Physician in Cardiology 2018.12-present - Wuhan University Renmin Hospital, Associate Chief Physician in Cardiology 2019.12-present - Wuhan University Renmin Hospital, Associate Professor in Cardiology
Awards	2023: Chinese Medical Association Young Elite in Cardiovascular Medicine 2022: Wuhan Sunlight Plan Talent 2021: Hubei Province Top Young Talent 2021: Wuhan University Top Innovative Young Talent 2019: Hubei Province Science and Technology Progress First Prize 2019: AHA International Early Career Investigator Award

University/Lab Affiliation and Title

Wuhan University

Faculty

Medical School

Academic Background & Achievements

2008-2016: Clinical Medicine (Bachelor to PhD) at Wuhan University
Hosted 3 projects from the National Natural Science Foundation
Selected as Hubei Province Top Young Talent

Work Experience

2016.07-2016.11 - Wuhan University Renmin Hospital, Resident Physician in Cardiology
2016.12-2018.11 - Wuhan University Renmin Hospital, Attending Physician in Cardiology
2018.12-present - Wuhan University Renmin Hospital, Associate Chief Physician in Cardiology
2019.12-present - Wuhan University Renmin Hospital, Associate Professor in Cardiology

Awards

2023: Chinese Medical Association Young Elite in Cardiovascular Medicine
2022: Wuhan Sunlight Plan Talent
2021: Hubei Province Top Young Talent
2021: Wuhan University Top Innovative Young Talent
2019: Hubei Province Science and Technology Progress First Prize
2019: AHA International Early Career Investigator Award

Areas of Focus	Pathophysiology and prevention of cardiac remodeling and heart failure Pathophysiology and prevention of cardiomyopathy
Publications	IRX2 regulates angiotensin II-induced cardiac fibrosis by transcriptionally activating EGR1 in male mice, Ma Zhen-Guo, 2023 Osteocrin, a novel myokine, prevents diabetic cardiomyopathy via restoring proteasomal activity, Ma Zhen-Guo, 2021 Endothelial ERG alleviates cardiac fibrosis via blocking endothelin-1-dependent paracrine mechanism, Ma Zhen-Guo, 2021 Matrine attenuates pathological cardiac fibrosis via RPS5/p38 in mice, Ma Zhen-Guo, 2021 FNDC5 alleviates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via activating AKT, Ma Zhen-Guo, 2020 Meteorin-like protein attenuates doxorubicin-induced cardiotoxicity via activating cAMP/PKA/SIRT1 pathway, Ma Zhen-Guo, 2020 Toll-like receptor 5 deficiency diminishes doxorubicin-induced acute cardiotoxicity in mice, Ma Zhen-Guo, 2020 Osteocrin attenuates inflammation, oxidative stress, apoptosis, and cardiac dysfunction in doxorubicin-induced cardiotoxicity, Ma Zhen-Guo, 2020 Geniposide protects against sepsis-induced myocardial dysfunction through AMPKα-dependent pathway, Ma Zhen-Guo, 2020 C1q-tumor necrosis factor-related protein-3 exacerbates cardiac hypertrophy in mice, Ma Zhen-Guo, 2019 T-bet deficiency attenuates cardiac remodelling in rats, Ma Zhen-Guo, 2018 CTRP3 attenuates cardiac dysfunction, inflammation, oxidative stress and cell death in diabetic cardiomyopathy in rats, Ma Zhen-Guo, 2017 Piperine Attenuates Pathological Cardiac Fibrosis via PPAR-γ/AKT Pathways, Ma Zhen-Guo, 2017 A77 1726 (Leflunomide) blocks and reverses cardiac hypertrophy and fibrosis in mice, Ma Zhen-Guo, 2018 Protection against cardiac hypertrophy by geniposide involves the GLP-1 receptor/AMPKα signalling pathway, Ma Zhen-Guo, 2016 Rosmarinic acid attenuates cardiac fibrosis following long-term pressure overload via AMPKα/Smad3 signaling, Ma Zhen-Guo, 2018 CTRP3 protected against doxorubicin-induced cardiac dysfunction, inflammation and cell death via activation of Sirt1, Ma Zhen-Guo, 2017 Asiatic acid protects against cardiac hypertrophy through activating AMPKα signalling pathway, Ma Zhen-Guo, 2016 Cardiac fibrosis: new insights into the pathogenesis, Ma Zhen-Guo, 2018

Areas of Focus

Pathophysiology and prevention of cardiac remodeling and heart failure
Pathophysiology and prevention of cardiomyopathy

Publications

IRX2 regulates angiotensin II-induced cardiac fibrosis by transcriptionally activating EGR1 in male mice, Ma Zhen-Guo, 2023
Osteocrin, a novel myokine, prevents diabetic cardiomyopathy via restoring proteasomal activity, Ma Zhen-Guo, 2021
Endothelial ERG alleviates cardiac fibrosis via blocking endothelin-1-dependent paracrine mechanism, Ma Zhen-Guo, 2021
Matrine attenuates pathological cardiac fibrosis via RPS5/p38 in mice, Ma Zhen-Guo, 2021
FNDC5 alleviates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via activating AKT, Ma Zhen-Guo, 2020
Meteorin-like protein attenuates doxorubicin-induced cardiotoxicity via activating cAMP/PKA/SIRT1 pathway, Ma Zhen-Guo, 2020
Toll-like receptor 5 deficiency diminishes doxorubicin-induced acute cardiotoxicity in mice, Ma Zhen-Guo, 2020
Osteocrin attenuates inflammation, oxidative stress, apoptosis, and cardiac dysfunction in doxorubicin-induced cardiotoxicity, Ma Zhen-Guo, 2020
Geniposide protects against sepsis-induced myocardial dysfunction through AMPKα-dependent pathway, Ma Zhen-Guo, 2020
C1q-tumor necrosis factor-related protein-3 exacerbates cardiac hypertrophy in mice, Ma Zhen-Guo, 2019
T-bet deficiency attenuates cardiac remodelling in rats, Ma Zhen-Guo, 2018
CTRP3 attenuates cardiac dysfunction, inflammation, oxidative stress and cell death in diabetic cardiomyopathy in rats, Ma Zhen-Guo, 2017
Piperine Attenuates Pathological Cardiac Fibrosis via PPAR-γ/AKT Pathways, Ma Zhen-Guo, 2017
A77 1726 (Leflunomide) blocks and reverses cardiac hypertrophy and fibrosis in mice, Ma Zhen-Guo, 2018
Protection against cardiac hypertrophy by geniposide involves the GLP-1 receptor/AMPKα signalling pathway, Ma Zhen-Guo, 2016
Rosmarinic acid attenuates cardiac fibrosis following long-term pressure overload via AMPKα/Smad3 signaling, Ma Zhen-Guo, 2018
CTRP3 protected against doxorubicin-induced cardiac dysfunction, inflammation and cell death via activation of Sirt1, Ma Zhen-Guo, 2017
Asiatic acid protects against cardiac hypertrophy through activating AMPKα signalling pathway, Ma Zhen-Guo, 2016
Cardiac fibrosis: new insights into the pathogenesis, Ma Zhen-Guo, 2018

Cardiac Remodeling Heart Failure Pathophysiology Prevention Cardiomyopathy Molecular Mechanisms Drug Development Clinical Research Cardiac Injury Translational Research

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Yanhong Tang - Wuhan University

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