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Zhen-Guo Ma
Medical School
Wuhan University
Hubei
Language: English, Chinese
Cardiac Remodeling
Heart Failure
Pathophysiology
Prevention
Cardiomyopathy
Molecular Mechanisms
Drug Development
Clinical Research
Cardiac Injury
Translational Research
Areas of Focus
- Pathophysiology and prevention of cardiac remodeling and heart failure
- Pathophysiology and prevention of cardiomyopathy
Work Experience
- 2016.07-2016.11 - Wuhan University Renmin Hospital, Resident Physician in Cardiology
- 2016.12-2018.11 - Wuhan University Renmin Hospital, Attending Physician in Cardiology
- 2018.12-present - Wuhan University Renmin Hospital, Associate Chief Physician in Cardiology
- 2019.12-present - Wuhan University Renmin Hospital, Associate Professor in Cardiology
Academic Background & Achievements
- 2008-2016: Clinical Medicine (Bachelor to PhD) at Wuhan University
- Hosted 3 projects from the National Natural Science Foundation
- Selected as Hubei Province Top Young Talent
Publications
- IRX2 regulates angiotensin II-induced cardiac fibrosis by transcriptionally activating EGR1 in male mice, Ma Zhen-Guo, 2023
- Osteocrin, a novel myokine, prevents diabetic cardiomyopathy via restoring proteasomal activity, Ma Zhen-Guo, 2021
- Endothelial ERG alleviates cardiac fibrosis via blocking endothelin-1-dependent paracrine mechanism, Ma Zhen-Guo, 2021
- Matrine attenuates pathological cardiac fibrosis via RPS5/p38 in mice, Ma Zhen-Guo, 2021
- FNDC5 alleviates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via activating AKT, Ma Zhen-Guo, 2020
- Meteorin-like protein attenuates doxorubicin-induced cardiotoxicity via activating cAMP/PKA/SIRT1 pathway, Ma Zhen-Guo, 2020
- Toll-like receptor 5 deficiency diminishes doxorubicin-induced acute cardiotoxicity in mice, Ma Zhen-Guo, 2020
- Osteocrin attenuates inflammation, oxidative stress, apoptosis, and cardiac dysfunction in doxorubicin-induced cardiotoxicity, Ma Zhen-Guo, 2020
- Geniposide protects against sepsis-induced myocardial dysfunction through AMPKα-dependent pathway, Ma Zhen-Guo, 2020
- C1q-tumor necrosis factor-related protein-3 exacerbates cardiac hypertrophy in mice, Ma Zhen-Guo, 2019
- T-bet deficiency attenuates cardiac remodelling in rats, Ma Zhen-Guo, 2018
- CTRP3 attenuates cardiac dysfunction, inflammation, oxidative stress and cell death in diabetic cardiomyopathy in rats, Ma Zhen-Guo, 2017
- Piperine Attenuates Pathological Cardiac Fibrosis via PPAR-γ/AKT Pathways, Ma Zhen-Guo, 2017
- A77 1726 (Leflunomide) blocks and reverses cardiac hypertrophy and fibrosis in mice, Ma Zhen-Guo, 2018
- Protection against cardiac hypertrophy by geniposide involves the GLP-1 receptor/AMPKα signalling pathway, Ma Zhen-Guo, 2016
- Rosmarinic acid attenuates cardiac fibrosis following long-term pressure overload via AMPKα/Smad3 signaling, Ma Zhen-Guo, 2018
- CTRP3 protected against doxorubicin-induced cardiac dysfunction, inflammation and cell death via activation of Sirt1, Ma Zhen-Guo, 2017
- Asiatic acid protects against cardiac hypertrophy through activating AMPKα signalling pathway, Ma Zhen-Guo, 2016
- Cardiac fibrosis: new insights into the pathogenesis, Ma Zhen-Guo, 2018
Awards
- 2023: Chinese Medical Association Young Elite in Cardiovascular Medicine
- 2022: Wuhan Sunlight Plan Talent
- 2021: Hubei Province Top Young Talent
- 2021: Wuhan University Top Innovative Young Talent
- 2019: Hubei Province Science and Technology Progress First Prize
- 2019: AHA International Early Career Investigator Award
